Humatch - fast, gene-specific joint humanisation of antibody heavy and light chains by Lewis Chinery, Jeliazko R. Jeliazkov, Charlotte M. Deane

“…However, the majority of antibody therapeutics are not genetically human, with initial therapeutic designs typically obtained from animal models. …”
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Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke by Nathan T. Lee, Fatimah Ahmedy, Natiara Mohamad Hashim, Khin Nyein Yin, Kai Ling Chin

“…Studies have implicated Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene as a genetic factor influencing stroke recovery. Still, the role of BDNF polymorphism in poststroke aphasia is relatively unclear. …”
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Diagnosis of Methyl Malonicaciduria from 2013 to 2018 by Alina Concepción Álvarez, Ivette Camayd Viera, Norma Elena de León Ojeda, Alina García García, Laritza Martínez Rey, Daniel Quintana Hernández

“…<strong>Foundation:</strong> methylmalonic aciduria is one of the most frequent organic acidurias and groups together a set of genetic defects, characterized by the excretion of elevated levels of urinemethyl malonic acid. …”
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Forensic evaluation of craniometric characteristics of the Kazakhstan population by Saule A. Mussabekova, Anastasiya O. Stoyan, Xeniya E. Mkhitaryan, Saule B. Zhautikova

“…Background: The human skull is the part of the skeleton most frequently used in population studies, as it was more exposed to genetic factors and less exposed to environmental factors. …”
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Advancing nuclear transfer cloning in zebrafish (Danio rerio) into a translational pathway using interdisciplinary tools. by Sarah Bodenstein, William Poulos, Fermin Jimenez, Michael Stout, Yue Liu, Zoltan M Varga, Jose Cibelli, Terrence R Tiersch

“…The Zebrafish International Resource Center (ZIRC) is an NIH-funded national stock center and germplasm repository that maintains and distributes genetically modified and wild-type zebrafish (Danio rerio) lines to the biomedical research community. …”
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Systemic lupus erythematosus in a patient with 22q11.2 deletion syndrome: A case report and review of the literature by Chen Sun, Pingyang Han, Juzhen Yan

“…Thymic dysplasia, T-cell lymphopenia, and B-cell abnormalities collectively contribute to the immunodeficiency and autoimmune manifestations observed in individuals with 22q11.2DS. Genetic factors such as 22q11.2DS should be considered in the diagnosis of childhood rheumatic diseases. …”
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A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice by Maximilian Wiesmann, Valerio Zerbi, Diane Jansen, Roy Haast, Dieter Lütjohann, Laus M. Broersen, Arend Heerschap, Amanda J. Kiliaan

“…APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer’s disease (AD). …”
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MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology by Cesar Seigi Fuziwara, Edna Teruko Kimura

“…Anaplastic thyroid cancer (ATC) is among the most lethal types of cancers, characterized as a fast-growing and highly invasive thyroid tumor that is unresponsive to surgery and radioiodine, blunting therapeutic efficacy. Classically, genetic alterations in tumor suppressor TP53 are frequent, and cumulative alterations in different signaling pathways, such as MAPK and PI3K, are detected in ATC. …”
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A Novel on Energy Management Strategy with Maximum Exploitation of Renewables and EV Storage in Distribution Networks by K. Ramakrishna Reddy, C. H. Hussaian Basha, V. Prashanth, C. Dhanamjayulu, Sujata Shivashimpiger, R. Likhitha

“…The water filling algorithm (WFA) is utilized to distribute the storage of EVs in each energy zone in an optimal manner, thereby achieving load flattening, minimizing energy costs, and reducing grid reliance. A multiobjective genetic algorithm (MOGA) is employed to solve a formulated multiobjective optimization problem for load flattening and voltage regulation, with optimal power transaction (OPT) serving as the decision variable. …”
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Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis by Bruno Guedes Baldi, Paulo Henrique Ramos Feitosa, Adalberto Sperb Rubin, Alexandre Franco Amaral, Carolina Salim Gonçalves Freitas, Cláudia Henrique da Costa, Eliane Viana Mancuzo, Ellen Caroline Toledo do Nascimento, Mariana Sponholz Araujo, Marcelo Jorge Jacó Rocha, Martina Rodrigues de Oliveira, Tatiana Senna Galvão, Pedro Paulo Teixeira e Silva Torres, Carlos Roberto Ribeiro Carvalho

“…In recent decades, a number of advances have been made in the understanding of the pathophysiology and management of LAM, leading to improvements in its prognosis: identification of the main genetic aspects and the role of the mechanistic target of rapamycin (mTOR) pathway; relationship with hormonal factors, mainly estrogen; characterization of pulmonary and extrapulmonary manifestations in imaging studies; identification and importance in the diagnosis of VEGF-D; a systematic diagnostic approach, often without the need for lung biopsy; use of and indications for the use of mTOR inhibitors, mainly sirolimus, for pulmonary and extrapulmonary manifestations; pulmonary rehabilitation and the management of complications such as pneumothorax and chylothorax; and the role of and indications for lung transplantation. …”
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A Real-Time Timetable Rescheduling Method for Metro System Energy Optimization under Dwell-Time Disturbances by Guang Yang, Junjie Wang, Feng Zhang, Shiwen Zhang, Cheng Gong

“…The real-time feature and self-adaptability of the method are attributed to the combinational use of Genetic Algorithm (GA) and Deep Neural Network (DNN). …”
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Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma by Zeynep Kacar, Eric Slud, Doron Levy, Julián Candia, Anuradha Budhu, Marshonna Forgues, Xiaolin Wu, Arati Raziuddin, Bao Tran, Jyoti Shetty, Yotsawat Pomyen, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Chirayu Auewarakul, Suleeporn Sangrajrang, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin Wei Wang

“…GTF2IRD2B mutations are enriched in HCC with linear evolution, while TP53 mutations are the most frequent genetic alterations in HCC with non-linear models. …”
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FHL1 as a prognostic biomarker and therapeutic target in acute promyelocytic leukaemia by Bo Luo, Wei Li, Jingyuan Zeng, Yingyu Mao, Shuang He, Nan Hu, Qulian Guo, Xiaoli Zheng

“…Most cases of leukemias are caused by environmental factors interacting with the cell’s genetic material, but treatment is still dominated by cell cycle drugs. …”
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Autonomous sortie scheduling for carrier aircraft fleet under towing mode by Zhilong Deng, Xuanbo Liu, Yuqi Dou, Xichao Su, Haixu Li, Lei Wang, Xinwei Wang

“…To efficiently solve the formulated HFSP, which is essentially a combinatorial problem with tightly coupled constraints, a chaos-initialized genetic algorithm is developed. The solution framework is validated by the simulation environment referring to the Fort-class carrier, exhibiting higher sortie efficiency when compared to existing strategies. …”
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Diversity, Distribution, and Evolution of Bioluminescent Fungi by Brian A. Perry, Dennis E. Desjardin, Cassius V. Stevani

“…Recent studies have elucidated the biochemical and genetic pathways of fungal bioluminescence and suggest the phenomenon originated a single time early in the evolution of the Agaricales. …”
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CRISPR/cas9 Allows for the Quick Improvement of Tomato Firmness Breeding by Qihong Yang, Liangyu Cai, Mila Wang, Guiyun Gan, Weiliu Li, Wenjia Li, Yaqin Jiang, Qi Yuan, Chunchun Qin, Chuying Yu, Yikui Wang

“…We generated single and double gene knockout mutants utilizing the tomato genetic transformation system. The fruit firmness of all knockout mutants exhibited a significant enhancement, with the most pronounced improvement observed in the double mutant. …”
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Rotavirus in Calves and Its Zoonotic Importance by Umer Seid Geletu, Munera Ahmednur Usmael, Fufa Dawo Bari

“…Reassortment is one of the important mechanisms for generating genetic diversity of rotaviruses and eventually for viral evolution. …”
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<i>Thermithiobacillus plumbiphilus</i> AAFK—Arsenic-Resistant Bacteria Isolated from Arsenopyrite Material by Artem Shaikin, Anton Zvonarev, Mikhail Vainshtein, Tatiana Abashina

“…Experiments on the arsenopyrite bioleaching showed that <i>T. plumbiphilus</i> AAFK can be used as an auxiliary bacterial culture capable of oxidizing reduced / intermediate sulfur compounds. The genetic basis of the <i>T. plumbiphilus</i> AAFK resistance to the arsenic compounds is discussed; the mechanisms are similar with the ones known for acidophilic thiobacilli. …”
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Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population by Hatice Gül Dursun, Hüseyin Osman Yılmaz, Recep Dursun, Sevsen Kulaksızoğlu

“…No statistically significant associations were detected in any of the investigated genetic models for the −318C>T polymorphism. The genotype distributions of +49A>G and CT60A>G were associated with Pv development. …”
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Detection and Validation of A2 Milk Suitable for Consumers Having Milk Intolerance by ELISA Method by Mediha Esra Yayla

“…Casein proteins, which make up 80% of the total proteins in cow's milk, consist of mainly A1 and A2 genetic types which differ by a mutation that causes conversion from proline to histidine. …”
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