Adrenal Hypoplasia Congenita Presenting as Congenital Adrenal Hyperplasia by Jennifer L. Flint, Jill D. Jacobson

“…We report on a patient with genetically confirmed adrenal hypoplasia congenita (AHC) whose presentation and laboratory abnormalities were consistent with the more common condition, congenital adrenal hyperplasia (CAH). …”
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Inhibiting Autophagy by Chemicals During SCAPs Osteodifferentiation Elicits Disorganized Mineralization, While the Knock-Out of <i>Atg5/7</i> Genes Leads to Cell Adaptation by Damien Le Nihouannen, Claudine Boiziau, Sylvie Rey, Nicole Agadzhanian, Nathalie Dusserre, Fabrice Cordelières, Muriel Priault, Helene Boeuf

“…By using a combination of chemical and genetic approaches to inhibit autophagy, we studied early and late events of osteoblastic differentiation. …”
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Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis by Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu

“…Two drug-resistant T lymphocyte epitopes, designated Rv1218c-p24 and Rv2477c-p182, were selected, and their immunogenic activities studied in vivo in genetically engineered mice. The immune activities of these two epitopes were improved with the help of complete Freund’s adjuvant (CFA). …”
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Attraction and aversion of noctuid moths to fermented food sources coordinated by olfactory receptors from distinct gene families by Xiao-Qing Hou, Dan-Dan Zhang, Hanbo Zhao, Yang Liu, Christer Löfstedt, Guirong Wang

“…Noctuid moths make a better use of fermented food sources than moths from other families, while the underlying molecular and genetic basis remain unexplored. As the fermentation progresses, yeasts lysis and the accumulation of metabolic byproducts alter the composition and the volatile release of the sugary substrates. …”
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Selection of suitable reference genes for gene expression studies in HMC3 cell line by quantitative real-time RT-PCR by Martina Fazzina, Matteo Bergonzoni, Francesca Massenzio, Barbara Monti, Flavia Frabetti, Raffaella Casadei

“…PD onset and progression are associated with factors considered possible causes of neuroinflammation, i.e. genetic mutations. In vitro models of microglial cells were established to identify specific molecular targets in PD through the analysis of gene expression data. …”
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Identifying Copy Number Variants under Selection in Geographically Structured Populations Based on -statistics by Hae-Hiang Song, Hae-Jin Hu, In-Hae Seok, Yeun-Jun Chung

“…By applying this Bayesian method to the publicly available CNV data, we identified the CNV loci that show signals of natural selection, which may elucidate the genetic basis of human disease and diversity.…”
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Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment by Morgan T. Sutton, David Fletcher, Santosh K. Ghosh, Aaron Weinberg, Rolf van Heeckeren, Sukhmani Kaur, Zhina Sadeghi, Adonis Hijaz, Jane Reese, Hillard M. Lazarus, Donald P. Lennon, Arnold I. Caplan, Tracey L. Bonfield

“…Cystic fibrosis (CF) is a genetic disease in which the battle between pulmonary infection and inflammation becomes the major cause of morbidity and mortality. …”
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Molecular Detection of FIPV among Imported Felines through Soekarno Hatta Airport, Indonesia by Fidyah Fitrawati, Suwarno, Ira Sari Yudaniayanti, Jola Rahmahani, Muchammad Yunus, Soeharsono, Desniwaty Karo-karo, Haeriah

“…Further research is needed to better understand the mechanism causing genetic diversification of FCoV or FIPV and its impact on the pathogenesis of FIP. …”
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Trans-kingdom sRNA silencing in the prevention and control of crop Fusarium wilt disease by Xin-Ni Huang, Yue Wang, Yan-Ting Li, Ying Xiao, Shou-Qiang Ouyang

“…Concerning the safety and costly process of generating genetically modified crops, a plant-disease management strategy not reliant on transgenic approaches remains the most economic and environmental-friendly option. …”
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Classification by production: an alternative criterion to categorization by Luis Yáñez, Nidia Rojas, Ricardo Aparicio, Manuel Mazzei, Eugenio Maldonado, Jairo Fernández, Nicola Fabbozzo, Rafael Rincón, Rafael Urdaneta

“…However, it was well known that the origin of the national inventory was mainly pure and of high genetic value, reasons for which it was considered justifiable to establish an alternative criterion, based on the simultaneous fulfillment of two principles: 1) The phenotypic approximation to the pattern of the corresponding breed; 2) Production adjusted to 244 days and standardized, as explained: LA1 0.5≤z<1; LA2 1≤z<1.5; LA3 1.5≤z. …”
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A Comprehensive Methodological Review of Major Developments in Bioinformatics Pipelines for Transcriptomic Data Analysis by Awais ALi, Syed Luqman Ali, Abdelkarem Omneya

“…RNA sequencing (RNA-Seq) is a common method used to study the complete set of RNA molecules (the transcriptome) in different cell types, genetic backgrounds, and environments. While many computational tools exist for analyzing large RNA-Seq datasets, there is still a need to thoroughly compare methods used to separate mixed cell populations (deconvolution). …”
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Effects of Elevated CO₂ on Maize Physiological and Biochemical Processes by Pirzada Khan, Tariq Aziz, Rahmatullah Jan, Kyung-Min Kim

“…Additionally, biofortification through traditional breeding and genetic engineering is proposed as a strategy to enhance folate level in maize to mitigate nutritional deficiencies. …”
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VIBRATION ANALYSIS AND OPTIMAL DESIGN OF LIGHT TRUCKS FUEL FILTER BRACKET by WU Hao, ZHONG ZiFeng

“…Lastly,the fuel filter bracket was multi-objective optimization analyzed based on Isight platform integrated CATIA,HYPERMESH and NASTRAN by adopting non-dominated sorting genetic algorithm. So the circular tube optimal parameters are obtained and the bracket maximum stress value are lower than the allowable stress after optimization. …”
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Current AAV-mediated gene therapy in sensorineural hearing loss by Jieyu Qi, Xiaolong Fu, Liyan Zhang, Fangzhi Tan, Nianci Li, Qiuhan Sun, Xiaojie Hu, Zuhong He, Ming Xia, Renjie Chai

“…With the development of genetic engineering technology, gene therapy has brought a promising treatment strategy for many previously intractable diseases. …”
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Phylogeographic analyses reveal recent dispersal and multiple Wolbachia infections of the bright-eyed ringlet Erebia oeme within the European mountain systems by Valentine Mewis, Martin Wendt, Thomas Schmitt

“…However, recent Wolbachia impact on the mitochondrial DNA and consequently influence on the intraspecific genetic structure was not detected.…”
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Location Optimization for Community Smart Parcel Lockers Based on Bilevel Programming by Xia Yang, Chenyang Wang, Xiaozheng He, Hedi Zhang, Guangming Xu

“…Then, a solution algorithm based on the genetic algorithm is proposed. Finally, some numerical experiments are carried out based on a medium-scale residential community in Jiading District, Shanghai. …”
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Point and Interval Predictions for Tanjiahe Landslide Displacement in the Three Gorges Reservoir Area, China by Yankun Wang, Huiming Tang, Tao Wen, Junwei Ma, Zongxing Zou, Chengren Xiong

“…Second, a new LSSVM model optimized by a genetic algorithm (GA) was implemented to estimate the noise variance. …”
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Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials by Farouc A. Jaffer, Matthias Nahrendorf, David Sosnovik, Kimberly A. Kelly, Elena Aikawa, Ralph Weissleder

“…This study thus provides a foundation for using MFNPs to image genetic and/or pharmacological perturbations of cellular inflammation in experimental atherosclerosis and for the future development of novel targeted nanomaterials for atherosclerosis.…”
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Preclinical Cognitive Markers of Alzheimer Disease and Early Diagnosis Using Virtual Reality and Artificial Intelligence: Literature Review by María de la Paz Scribano Parada, Fátima González Palau, Sonia Valladares Rodríguez, Mariano Rincon, Maria José Rico Barroeta, Marta García Rodriguez, Yolanda Bueno Aguado, Ana Herrero Blanco, Estela Díaz-López, Margarita Bachiller Mayoral, Raquel Losada Durán

“…ResultsFollowing an analysis of 38 selected articles, we highlight verbal episodic memory as a sensitive preclinical AD marker, with supporting evidence from neuroimaging and genetic profiling. Executive functions precede memory decline, while processing speed is a significant correlate. …”
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Mutational Analysis of BRAFV600E by Polymerase Chain Reaction in Breast Cancer: A Narrative Review by Simran Khan, Arvind Bhake

“…A major cause of cancer-related death for women globally is breast cancer, calling for molecular insights to better prognosis and treatment. One of the genetic changes that contributes to the constitutive activation of the MAPK/ERK (mitogen-activated protein kinase/extracellular signal-regulated kinase) pathway and promoting carcinogenesis is the BRAFV600E mutation, which has been extensively studied in melanoma. …”
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