Beyond the microbiome: unraveling gut dysbiosis and its impact on systemic lupus erythematosus by Yara Safwat Roshdy, Shwikar Mahmoud Ahmed, Mona Gamaleldeen Morsi, Ahmed Shaaban, Samar Farouk Fouad Mostafa

“…Background Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors, with gut microbiota (GM) changes emerging as a key environmental contributor.Methods A total of 42SLE patients and 30 age – and sex-matched healthy controls were enrolled. …”
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Molecular phylogeny and comparative chloroplast genome analysis of the type species Crucigenia quadrata by Ting Wang, Huan Feng, Huan Zhu, Bojian Zhong

“…Nucleotide diversity analysis highlights six genes (ccsA, psbF, chlN, cemA, rps3, rps18) as hotspots for genetic variation. Coding gene sequence divergence analyses indicate that four genes (cemA, clpP, psaA, rps3) are subject to positive selection. …”
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Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update by Arif Malik, Misbah Sultana, Aamer Qazi, Mahmood Husain Qazi, Gulshan Parveen, Sulayman Waquar, Abdul Basit Ashraf, Mahmood Rasool

“…Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. …”
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CXCL1-Triggered Interaction of LFA1 and ICAM1 Control Glucose-Induced Leukocyte Recruitment during Inflammation In Vivo by Kirsten Buschmann, Lutz Koch, Natascha Braach, Hanna Mueller, David Frommhold, Johannes Poeschl, Peter Ruef

“…Experiments with functional or genetic inhibition of the chemokine receptor CXCR2, intercellular adhesion molecule 1 (ICAM1), and lymphocyte function antigen 1 (LFA1) suggest that keratino-derived-chemokine CXCL1-triggered interactions of ICAM1 and LFA1 are crucially involved in the trauma model of inflammation. …”
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Causal relationship between educational attainment and the occurrence of venous thromboembolism by Sitong Guo, Sitao Tan, Shiran Qin, Dandan Xu, Henghai Su, Xiaoyu Chen

“…Use the MR-Egger method for pleiotropy analysis and leave one method for sensitivity analysis to verify the reliability of the data. Results Genetically predicted decreased EA was associated with a decreased risk of VTE in both the FinnGen consortium and UK Biobank (FinnGen-VTE: OR = 0.848; 95% CI 0.776—0.927; P = 2.84 × 10–4; UKB-VTE OR = 0.996; 95% CI 0.994—0.999; P = 0.008) under a multiplicative random-effects IVW model. …”
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Experimental and Mathematical Studies for Optimality of GTAW Parameters on Similar and Dissimilar Steel Substrates by Bandaru Kiran, Dega Nagaraju, Senthil Kumaran Selvaraj, Baye Molla

“…Furthermore, tensile tests are carried out for the weldments with optimal predefined weld parameters, and subsequently, the welded specimens with better tensile strength are discussed in the results. Genetic algorithm and mathematical modelling are opted for selecting the final optimal welding parameters. …”
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Global Distribution of Common Variable Immunodeficiency (CVID) in the Light of the UNDP Human Development Index (HDI): A Preliminary Perspective of a Rare Disease by Niels Weifenbach, Annalena A. C. Schneckenburger, Stefan Lötters

“…As a potential alternative explanation, we briefly discuss the possibility that variation in CVID prevalence is related to human genetic lineage.…”
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Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles by Jacob R. Shaw, Nicholas Caprio, Nhu Truong, Mehari Weldemariam, Anh Tran, Nageswara Pilli, Swarnima Pandey, Jace W. Jones, Maureen A. Kane, Ryan M. Pearson

“…Pharmacological inhibition and genetic knockout studies validate that NP coronas mediate this response through TLR4/MyD88/NF-κB signaling. …”
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Digital-twin driven alignment control method for marine shafting with air spring vibration isolation system by Song Liu, Liang Shi, Wei Xu, ZeChao Hu

“…To obtain the optimal air spring pressures, the genetic algorithm is introduced to solve the optimization problem, fully exploiting its global search capacity. …”
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GmERF13 mediates salt inhibition of nodulation through interacting with GmLBD16a in soybean by Xinfang Zhu, Xifeng Yan, Weijun Li, Mengyue Zhang, Junchen Leng, Qianqian Yu, Like Liu, Dawei Xue, Dajian Zhang, Zhaojun Ding

“…Abstract While the genetic regulation of nodule formation has been well explored, the molecular mechanisms by which abiotic stresses, such as salt stress, impede nodule formation remain largely elusive. …”
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Chemokines in Renal Diseases by Stephan Segerer, Peter J. Nelson

“…Therefore, it is not surprising that chemokines play important roles in a wide range of human diseases, including genetic immunodeficiencies, infections, autoimmune diseases, and malignant tumors. …”
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MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes by Néron, Bertrand, Denise, Rémi, Coluzzi, Charles, Touchon, Marie, Rocha, Eduardo P.C., Abby, Sophie S.

“…Complex cellular functions are usually encoded by a set of genes in one or a few organized genetic loci in microbial genomes. Macromolecular System Finder (MacSyFinder) is a program that uses these properties to model and then annotate cellular functions in microbial genomes. …”
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Cytokine Storm Syndrome Responsive to IL-1 Inhibition in Trisomy 21 by Aimee Magnarelli, Julia Shalen, Maria J. Gutierrez

“…Trisomy 21 (TS21), also known as Down syndrome, is a genetic disorder associated with immune dysfunction, increased infection susceptibility, and inflammation. …”
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A Micro-RNA Connection in BRafV600E-Mediated Premature Senescence of Human Melanocytes by Gang Ren, Jingwei Feng, Ila Datar, Aaron H. Yeung, Srinivas Vinod Saladi, Yongqing Feng, Ivana de la Serna, Kam C. Yeung

“…Recent high-throughput-sequencing of the cancer genome has identified oncogenic mutations in BRaf genetic locus as one of the critical events in melanomagenesis. …”
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The effect of AKT inhibition in α-synuclein-dependent neurodegeneration by Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Sokol V. Todi, Sokol V. Todi, Peter A. LeWitt, Peter A. LeWitt, Peter A. LeWitt, Wei-Ling Tsou

“…We observed that administration of the AKT inhibitor, A-443654 led to mild improvements in both survival and motor function in flies expressing human α-Syn. Genetic studies revealed that reduction of AKT levels decreased α-Syn protein levels, concomitant with improved physiological outcomes. …”
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Virtual Node-Driven Cloud–Edge Collaborative Resource Scheduling for Surveillance with Visual Sensors by Xinyang Gu, Zhansheng Duan, Guangyuan Ye, Zhenjun Chang

“…Additionally, we propose three alternative virtual node-driven scheduling algorithms, the extension of a random algorithm, a genetic algorithm, and a heuristic algorithm, respectively. …”
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Relationship between the CUBN and the MIA3 gene copy number variation and growth traits in different cattle breeds by Yue Han, Jiwei Liu, Congcong Zhang, Ming Sun, Xuanyu Li, Hongliang Liu, Shengnan Li, Yongchao Zhu, Ruidong Li, Xiaotong Luo, Yumin Zhao, Jian Wu

“…Copy number variations (CNV) are important genetic variations. The endogenous factors cobalamin receptor (CUBN) and MIA SH3 domain ER-derived factor 3 (MIA3) are associated with bone/muscle development and intramuscular fat deposition. …”
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Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophy by Sarah M. Schneider, Macie L. Mackey, Savannah Wilkinson, Lee-Jae Guo, Peter P. Nghiem

“…Bone morphology has not been extensively studied in the genetic homolog, golden retriever muscular dystrophy (GRMD). …”
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Combined Parental Thrombophilia Gene Mutation Defects in Couples with Repeated Pregnancy Loss by Mehdi Kashifard, Zahra Basirat, Fatemeh Ramezani, Faeze Ghofrani, Masoumeh Golsorkhtabaramiri

“…Background: Several genetic mutations in female thrombotic defects have recently been shown to affect recurrent pregnancy loss (RPL); however, it is unclear which common parental mutations are involved in thrombosis-associated repeated pregnancy loss RPL. …”
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Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model by Wei Li, Xue Wang, Keyuan Chen, Yaohong Zhu, Guiyan Yang, Yipeng Jin, Jiufeng Wang

“…However, the intrinsic instability associated with the in vivo delivery of AMPs constitutes a substantial impediment to their therapeutic efficacy in treating infections. In this study, we genetically modified Bacillus subtilis (B. subtilis) WB600 to express Zophobas atratus defensin (ZD), an antimicrobial peptide with broad-spectrum activity isolated from Zophobas atratus, for oral administration. …”
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