Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species by Alexander Dumbai Joe, Runze Liu, Xiao Luo, Ruqiya Syed, Farhan Aslam, Zhenying Luo, Zhitian Zheng

“…We examine the molecular, genetic, and environmental factors contributing to this resistance. …”
Get full text

Can mechanistic constraints on recombination reestablishment explain the long-term maintenance of degenerate sex chromosomes? by Lenormand, Thomas, Roze, Denis

“…The assumption of a lack of genetic variation to restore recombination seems also implausible given known mechanisms to restore a recombining pair of sex chromosomes.…”
Get full text

A data-driven intelligent fault diagnosis framework for permanent magnet in PMSM by Huizhen Wang, Lei Wang, QiYa Wu, Haoying Pei, Lijun Diao

“…Second, fault diagnosis is carried out using the Genetic Algorithm-Support Vector Machine (GA-SVM) to accurately classify demagnetization faults. …”
Get full text

Quantum computational infusion in extreme learning machines for early multi-cancer detection by Anas Bilal, Muhammad Shafiq, Waeal J. Obidallah, Yousef A. Alduraywish, Haixia Long

“…This study presents a hybrid model integrating Extreme Learning Machine (ELM) with FuNet transfer learning, applied on a multi-cancer dataset and optimized using the Quantum-Genetic Binary Grey Wolf Optimizer (Q-GBGWO). This model leverages a diverse feature fusion strategy, enhancing the extraction of critical imaging features, while Q-GBGWO optimizes ELM parameters to achieve superior classification performance. …”
Get full text

RTEL1 is upregulated in gastric cancer and promotes tumor growth by Chunyu Yang, Suzeng Wang, Ge Gao, Peiwen Xu, Mengyuan Qian, Yuan Yin, Surui Yao, Zhaohui Huang, Zehua Bian

“…GC is a highly heterogeneous disease and its progression is associated with complex interplay between genetic and environmental factors. Identifying novel genes and pathways involved in GC development is crucial for improving the therapeutic outcome. …”
Get full text

Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex by Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

“…Abstract Type I-E CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated proteins) system is one of the most extensively studied RNA-guided adaptive immune systems in prokaryotes, providing defense against foreign genetic elements. Unlike the previously characterized Cas3 nuclease, which exhibits progressive DNA cleavage in the typical type I-E system, a recently identified HNH-comprising Cascade system enables precise DNA cleavage. …”
Get full text

The Determination of Fetal Gender with Gestational Sac Volume Maternal Age and Body Mass Index by Aytekin Aydın, Mustafa Öztürk, Murat Gökhan Kinaş

“… OBJECTIVE: In this study, we aimed to examine the effects of fetal gender on Gestational Sac Volume (GSV), maternal age and Body Mass Index (BMI) between 10 and 12 gestational weeks in order to detect the fetal gender in diseases being transferred genetically with x by using non-invasive methods. STUDY DESIGN: 37 pregnant women who came for routine antenatal controls between 10 and 12 gestational weeks were incorporated in study. …”
Get full text

Beyond the microbiome: unraveling gut dysbiosis and its impact on systemic lupus erythematosus by Yara Safwat Roshdy, Shwikar Mahmoud Ahmed, Mona Gamaleldeen Morsi, Ahmed Shaaban, Samar Farouk Fouad Mostafa

“…Background Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors, with gut microbiota (GM) changes emerging as a key environmental contributor.Methods A total of 42SLE patients and 30 age – and sex-matched healthy controls were enrolled. …”
Get full text

Causal relationship between educational attainment and the occurrence of venous thromboembolism by Sitong Guo, Sitao Tan, Shiran Qin, Dandan Xu, Henghai Su, Xiaoyu Chen

“…Use the MR-Egger method for pleiotropy analysis and leave one method for sensitivity analysis to verify the reliability of the data. Results Genetically predicted decreased EA was associated with a decreased risk of VTE in both the FinnGen consortium and UK Biobank (FinnGen-VTE: OR = 0.848; 95% CI 0.776—0.927; P = 2.84 × 10–4; UKB-VTE OR = 0.996; 95% CI 0.994—0.999; P = 0.008) under a multiplicative random-effects IVW model. …”
Get full text

MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes by Néron, Bertrand, Denise, Rémi, Coluzzi, Charles, Touchon, Marie, Rocha, Eduardo P.C., Abby, Sophie S.

“…Complex cellular functions are usually encoded by a set of genes in one or a few organized genetic loci in microbial genomes. Macromolecular System Finder (MacSyFinder) is a program that uses these properties to model and then annotate cellular functions in microbial genomes. …”
Get full text

Combined Parental Thrombophilia Gene Mutation Defects in Couples with Repeated Pregnancy Loss by Mehdi Kashifard, Zahra Basirat, Fatemeh Ramezani, Faeze Ghofrani, Masoumeh Golsorkhtabaramiri

“…Background: Several genetic mutations in female thrombotic defects have recently been shown to affect recurrent pregnancy loss (RPL); however, it is unclear which common parental mutations are involved in thrombosis-associated repeated pregnancy loss RPL. …”
Get full text

Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model by Wei Li, Xue Wang, Keyuan Chen, Yaohong Zhu, Guiyan Yang, Yipeng Jin, Jiufeng Wang

“…However, the intrinsic instability associated with the in vivo delivery of AMPs constitutes a substantial impediment to their therapeutic efficacy in treating infections. In this study, we genetically modified Bacillus subtilis (B. subtilis) WB600 to express Zophobas atratus defensin (ZD), an antimicrobial peptide with broad-spectrum activity isolated from Zophobas atratus, for oral administration. …”
Get full text

A Highly Efficient System for Separating Glandular and Non-glandular Trichome of Cucumber Fruit for Transcriptomic and Metabolomic Analysis by Lei Sun, Zhongxuan Feng, Fang Wang, Yu Qi, Menghang An, Lin Yang, Min Feng, Mingqi Wang, Huazhong Ren, Xingwang Liu

“…This advancement not only addresses existing limitations but also facilitates comprehensive studies aimed at exploring the genetic and biochemical diversity present within cucumber trichomes, thereby opening avenues for broader agricultural and biological research applications.…”
Get full text

The Science of Memory Loss: Insights into Alzheimer’s Disease by Agnieszka Starzyk, Piotr Charzewski

“…Since the 2016 Seminar, substantial progress has been made in understanding AD’s complex pathogenesis, identifying genetic risk and protective factors, and developing novel diagnostic biomarkers and therapeutic strategies. …”
Get full text

Synthetic wheat as a new source of flour quality under drought conditions: Associations with solvent retention capacity. by Niloofar Mokhtari, Mohammad Mahdi Majidi, Aghafakhr Mirlohi

“…Correlation analysis indicated that genetic improvement for high-yielding varieties can be achieved by producing more damaged starch, higher water absorption, hardness, and lower gluten strength, and zeleny (ZEL). …”
Get full text

In vitro efficacy of plant growth-promoting rhizobacteria isolated from ginger (Zingiber officinale) rhizosphere for biological control of plant pathogens by Ruth Meike Jayanti, Sabrina Ayu Kristianingrum, Andree Wijaya Setiawan

“…Research on the isolation of PGPR from ginger (Zingiber officinale) rhizosphere in Indonesia remains limited, highlighting the need for further exploration to support genetic resource conservation and sustainable agricultural practices. …”
Get full text

Machine Learning with Tunicate Swarm Optimization for Improved Disc Herniation Prediction by Theofilos Gofas, Argyros Maris

“…The many variables that contribute to disc herniation are examined in this study, including age-related deterioration, genetic predispositions, lifestyle choices, and traumatic experiences. …”
Get full text

A lethal disease of the European bison – posthitis is conditionally determined by its genomics by Sazia Kunvar, Sylwia Czarnomska, Cino Pertoldi, Astrid V. Stronen, Iwona Ruczyńska, Małgorzata Tokarska

“…Studies indicated the disease could have a genetic background after tools developed for cattle (Bos taurus) revealed genomic regions that could be associated with its occurrence. …”
Get full text

Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis by Bruno Guedes Baldi, Paulo Henrique Ramos Feitosa, Adalberto Sperb Rubin, Alexandre Franco Amaral, Carolina Salim Gonçalves Freitas, Cláudia Henrique da Costa, Eliane Viana Mancuzo, Ellen Caroline Toledo do Nascimento, Mariana Sponholz Araujo, Marcelo Jorge Jacó Rocha, Martina Rodrigues de Oliveira, Tatiana Senna Galvão, Pedro Paulo Teixeira e Silva Torres, Carlos Roberto Ribeiro Carvalho

“…In recent decades, a number of advances have been made in the understanding of the pathophysiology and management of LAM, leading to improvements in its prognosis: identification of the main genetic aspects and the role of the mechanistic target of rapamycin (mTOR) pathway; relationship with hormonal factors, mainly estrogen; characterization of pulmonary and extrapulmonary manifestations in imaging studies; identification and importance in the diagnosis of VEGF-D; a systematic diagnostic approach, often without the need for lung biopsy; use of and indications for the use of mTOR inhibitors, mainly sirolimus, for pulmonary and extrapulmonary manifestations; pulmonary rehabilitation and the management of complications such as pneumothorax and chylothorax; and the role of and indications for lung transplantation. …”
Get full text

A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration by Hongfan Yang, Haofei Huang, Kunlin Pu

“…Abstract Age-related macular degeneration (AMD) is a complex multifactorial disease with a significant genetic component. Despite extensive research efforts, the underlying molecular mechanisms remain elusive, necessitating innovative approaches to identify specific genes involved in the pathogenesis of AMD and to elucidate their functional mechanisms. …”
Get full text