Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India by Ranjan S. Rana, Bitan Naik, Mahima Yadav, Usha Singh, Anup Singh, Shailja Singh

“…The most appropriate hypothesis states that genetic susceptibility in the presence of environmental risk factors predisposes to SLE. …”
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Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequen... by Gian Marco Ghiggeri, Maddalena Gigante, Armando Di Donato

“…The kidney glomerular podocytes are the cellular target of many chronic nephropathies both determined and acquired genetically. Mutations that affected the expression and/or the function of nephrin, a key component of the slit-diaphragm, are often causes of these pathologies. …”
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Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants by Nathalie Grova, Henri Schroeder, Jean-Luc Olivier, Jonathan D. Turner

“…This model has been refined over the years to give the current “three-hit” model that considers the individual’s genetic factors as a first “hit.” It has an immediate interaction with the early-life exposome (including persistent organic pollutants) that can be considered to be a second “hit.” …”
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p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension by Chaowei Hu, Kun Zuo, Kuibao Li, Yuanfeng Gao, Mulei Chen, Roumu Hu, Ye Liu, Hongjie Chi, Hongjiang Wang, Yanwen Qin, Xiaoyan Liu, Jiuchang Zhong, Jun Cai, Xinchun Yang, Jing Li

“…These novel findings yield new insights into the genetic and biological basis of hypertension and are fundamental for further studies to explore the intervention strategies targeting L3MBTL4 and p38/JNK to counteract the progression of hypertension.…”
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The Integration of Multimodal Networks: The Generalized Modal Split and Collaborative Optimization of Transportation Hubs by Yifei Cai, Jun Chen, Da Lei, Jiang Yu

“…The GMS/TAP is formulated as a nonlinear optimization problem (NLP) and is solved using a hybrid method of the successive average (MSA) algorithm. A hybrid genetic search with advanced diversity control (HGSADC) is developed to solve the bilevel model, where the exploration of the search space is expanded using the biased fitness function and diversification mechanism. …”
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Light quality‐dependent roles of REVEILLE proteins in the circadian system by Cassandra L. Hughes, Yuyan An, Julin N. Maloof, Stacey L. Harmer

“…To investigate the basis of these blue light‐specific circadian phenotypes, we examined RVE protein abundances and degradation rates in blue and red light and found no significant differences between these conditions. We next examined genetic interactions between RVE genes and ZEITLUPE and ELONGATED HYPOCOTYL5, two factors with blue light‐specific functions in the clock. …”
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Gastrointestinal protozoa in pet cats from Anhui province: prevalence and molecular characterization by Hao Zhang, Xing Tong, Zhonghui Ma, Tao Zhang, Feng Wu, Qiong Wu, Congshan Yang, Chunyang Han

“…The evolutionary relationships and genetic characteristics of G. intestinalis based on the GDH gene, Cryptosporidium based on the SSU rRNA gene, and E. bieneusi based on the ITS sequence were assessed: five cases of G. intestinalis were identified, with four belonging to assemblage F and one to zoonotic assemblage B, two Cryptosporidium cases were identified as Cryptosporidium felis, and all eight E. bieneusi cases were identified as belonging to group 1, with three cases being genotype D, three EbpA, and two EbpC.DiscussionAge, neutering status, and deworming were identified as potential risk factors. …”
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Intensity of Oestrus Signalling Is the Most Relevant Indicator for Animal Well-Being in High-Producing Dairy Cows by Emanuel Garcia, Jan Hultgren, Pontus Fällman, Johanna Geust, Bo Algers, George Stilwell, Stefan Gunnarsson, Heriberto Rodriguez-Martinez

“…Oestrous intensity of 37 heifers (H) and 30 1st-parity dairy cows (C1) either Swedish Red (32) or Swedish Holstein (35) with high genetic potential for milk production, was studied in relation to AI. …”
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RSM-, ANN-, and GA-Based Process Optimization for Acid Centrifugation Treatment of Cane Molasses Toward Mitigating Calcium Oxide Fouling in Ethanol Plant Heat Exchanger by Lata Deso Abo, Sintayehu Mekuria Hailegiorgis, Mani Jayakumar, Sundramurthy Venkatesa Prabhu, Gadissa Tokuma Gindaba, Abas Siraj Hamda, B. S. Naveen Prasad

“…Furthermore, the implementation of an artificial neural network (ANN) provided a better prediction model for CaO reduction, with a substantial R-squared value of 0.99866. However, the genetic algorithm (GA) optimization resulted in an actual CaO reduction of 66.21 wt.% with a t-test value of 0.497726.…”
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Investigating the Causes of Blindness and Vision Impairment in Children Younger Than 15 Years Old by Abbas Riazi, Fatemeh Riazi

“…Many of these diseases are genetic; no specific treatment has yet been discovered. …”
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Identification of TMPRSS3 as a Significant Contributor to Autosomal Recessive Hearing Loss in the Chinese Population by Xue Gao, Sha-Sha Huang, Yong-Yi Yuan, Jin-Cao Xu, Ping Gu, Dan Bai, Dong-Yang Kang, Ming-Yu Han, Guo-Jian Wang, Mei-Guang Zhang, Jia Li, Pu Dai

“…Hereditary hearing loss is characterized by a high degree of genetic heterogeneity. Mutations in the TMPRSS3 (transmembrane protease, serine 3) gene cause prelingual (DFNB10) or postlingual (DFNB8) deafness. …”
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A scoping review of published literature on chikungunya virus. by Mariola Mascarenhas, Sophiya Garasia, Philippe Berthiaume, Tricia Corrin, Judy Greig, Victoria Ng, Ian Young, Lisa Waddell

“…In addition, a repository of CHIKV mutations associated with evolutionary fitness and adaptation has been created by compiling and characterizing these genetic variants as reported in scientific literature.…”
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Breeding for postharvest physiological deterioration in cassava: problems and strategies by Wilton Mbinda, Asunta Mukami

“…In this review, we discuss the available knowledge on (i) physiology and biochemistry of cassava storage root with regard to PPD (ii) strategies for minimizing PPD in cassava storage roots (iii) traits associated with PPD tolerance as essential targets for prolonging cassava storage root shelf life, and (iv) suggestions for novel genomic tools and modern genetic and breeding approaches for prolonging shelf-life in cassava storage roots. …”
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Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. by Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne

“…We demonstrate that targets of miR-505-5p are enriched in fatty acid metabolism pathways and overexpression of miR-505-5p decreased neuronal fatty acid metabolism in vitro. miR-505-5p targets are associated with increased BMI in human genetic studies. Intra-cerebroventricular injection of miR-505-5p in wild-type mice increased HFD intake, mimicking the phenotype observed in offspring exposed to maternal obesity. …”
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Image Evolution Using 2D Power Spectra by Michael Gircys, Brian J. Ross

“…We refine fitness measures based on Fourier analysis and spatial frequency and apply them within a genetic programming environment for image synthesis. …”
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A core set of risk factors in individuals at risk of rheumatoid arthritis: a systematic literature review informing the EULAR points to consider for conducting clinical trials and... by Daniel Aletaha, Kulveer Mankia, Paul Emery, Deshire Alpizar-Rodriguez, Andreas Kerschbaumer, Andrea Di Matteo, Heidi Siddle, Joel Kerry

“…Fifty-three articles included data on risk factors including autoantibodies, subclinical inflammation on imaging, clinical features, serum and cellular biomarkers and genetic markers. Risk factors were dependent on the at-risk population. …”
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Understanding the Spectrum of Mild Clinical Outcomes and Novel Findings in Arterial Tortuosity Syndrome Among Qatari Patients: Implications of SLC2A10 Mutation by Muhammed Riyas K. Rahmath, Haytham Ibrahim, Muhammad Faiyaz-Ul-Haque, Zafar Nawaz, Ahmad Zitoun, Ahmed Hussein, Ahmed Sadek, Ayman El-Menyar, Reema Kamal, Hassan Al-Thani, Gulab Sher

“…The cohort study included 21 patients who were genetically confirmed by mutations in the SLC2A10 gene. …”
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Clinical Phenotype of Fucosidosis in Cuba by Víctor Jesús Tamayo Chang, George Alberto Pérez Benítez

“…<br /><strong>Method:</strong> a case series study was carried out, for which the clinical and genetic histories of patients with α-L-fucosidase enzyme activity in leukocytes were analyzed, quantified by spectrofluorimetry 30 % lower than the activity of healthy controls. …”
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Comparative characterization of Leporipoxvirus members’ reproduction in continuous cell culture by O. G. Lapteva, S. G. Yurkov, I. P. Sindryakova, A. V. Lunitsin

“…Prepared cultures were identified as myxoma virus and Shope fibroma virus with molecular genetic analysis. Tests of the viruses for their antigenic relatedness showed that antibodies against myxoma virus were able to neutralize Shope fibroma virus also. …”
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Characterization and molecular biological identification of tick species in Nanjing city by Luyao SUN, Xuemin CHEN, Bingdong SONG, Yan ZHANG, Yanqun SUN, Yue MIN, Shougang ZHANG

“…Tick species composition varied among habitats and animal hosts. No significant genetic variation within tick species was observed.…”
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