Alleviating the public health burden of hypertension: debating precision prevention as a possible solution by Madeleine J. Samakosky, Shane A. Norris

“…Precision prevention, a tailored health intervention approach utilising individual and population-specific factors – genetic, environmental, and social determinants – offers a potential alternative. …”
Get full text

Photovoltaic Generation Integration with Radial Feeders Using GA and GIS by Elias Mandefro Getie, Belachew Bantyirga Gessesse, Tewodros Gera Workneh

“…The optimal allocation of PV has been done using the Genetic Algorithm (GA) for optimization of a multiobjective function with different constraints. …”
Get full text

Exposure to major coronary heart disease events reduces lung cancer risk: a mendelian randomization study based on a European population by Dongming He, Hongting Lu, Xinhuai Ou, Tiaozhan Zheng, Zhiwen Zheng, Zhanyu Xu, Xiaohong Duan, Shikang Li

“…Methods Utilizing data from the IEU OpenGWAS project and FinnGen, this study employed a two-sample MR approach, with genetic variants serving as instrumental variables. …”
Get full text

The impact of gut microbiome on neuro-autoimmune demyelinating diseases by Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold

“… Demyelinating diseases, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and chronic inflammatory demyelinating polyneuropathy (CIDP), are characterized by dysregulated immune responses to self-antigens, leading to myelin loss. Genetic predisposition and environmental factors, such as alterations in the gut microbiome, influence these conditions. …”
Get full text

Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report... by Yohei Ishiki, Atsuko Tamaki, Ken-ichiro Honma, Ken Yonaha, Takamitsu Yabiku, Taiki Teruya, Moriyuki Uehara, Yoshiro Nakayama, Rei Chinen, Tsugumi Uema, Sawako Nakachi, Shiki Okamoto, Hiroaki Masuzaki

“…PSIS has been thought to be a prenatal developmental event resulting from a couple of genetic aberrations. In typical PSIS, anterior pituitary hormone deficiencies are restricted to growth hormone (GH) and gonadotropin during the pediatric age, gradually and generally progressing to panhypopituitarism in most cases. …”
Get full text

Assessing chemical exposure risk in breastfeeding infants: An explainable machine learning model for human milk transfer prediction by Xiaojie Huang, Jiajia Chen, Peineng Liu

“…The balanced random forest classifier, optimized using the genetic algorithm for feature selection, achieved an area under the receiver operating characteristic curve (AUC) of 0.8708 and an accuracy of 82.67 % on the internal test set, with an accuracy of 86.36 % on the external validation set. …”
Get full text

A New Method for Fault Detection and Location in a Low-Resistance Grounded Power Distribution Network Using Voltage Phasor of D-PMUs Data by Masoud Najafzadeh, Jaber Pouladi, Ali Daghigh, Jamal Beiza, Sima Shahmohamadi

“…In the first technique, the genetic optimization algorithms and particle swarm optimization for nonlinear modeling of fault position along the distribution line have been utilized for different single-phase, two-phase, and three-phase faults, and in the second technique, neural fuzzy network training has been proposed by different phasor measurement devices. …”
Get full text

Familial Hemiplegic Migraine with Severe Attacks: A New Report with ATP1A2 Mutation by E. Martínez, R. Moreno, L. López-Mesonero, I. Vidriales, M. Ruiz, A. L. Guerrero, J. J. Tellería

“…Her mother was diagnosed with hemiplegic migraine without genetic confirmation. She presented with fever, decreased consciousness, left gaze preference, mixed aphasia, right facial palsy, right hemiplegia, and left crural paresis. …”
Get full text

Enhancing Pan evaporation predictions: Accuracy and uncertainty in hybrid machine learning models by Khabat Khosravi, Aitazaz A. Farooque, Amir Naghibi, Salim Heddam, Ahmad Sharafati, Javad Hatamiafkoueieh, Soroush Abolfathi

“…The models investigated include M5 Prime (M5P), M5Rule (M5R), Kstar, as well as their hybridized versions employing Bagging (BA), the adaptive neuro-fuzzy inference system (ANFIS), ANFIS-GA (genetic algorithm), and long short-term memory (LSTM) networks. …”
Get full text

mbctools: A User-Friendly Metabarcoding and Cross-Platform Pipeline for Analyzing Multiple Amplicon Sequencing Data across a Large Diversity of Organisms by Barnabé, Christian, Sempéré, Guilhem, Manzanilla, Vincent, Millan, Joel Moo, Amblard-Rambert, Antoine, Waleckx, Etienne

“…It can handle the most common tasks in metabarcoding pipelines such as paired-end merging, primer trimming, quality filtering, sequence denoising, zero-radius operational taxonomic unit (ZOTU) filtering, and has the capability to process multiple genetic markers simultaneously. mbctools is a menu-driven program that eliminates the need for expertise in command-line skills and ensures documentation of each analysis for reproducibility purposes. …”
Get full text

Variation in Illipe Nut's Fat Yield of Tengkawang-producing Shorea from Several Provenances and Land Races by Budi Leksono, Lukman Hakim

“…Both species-provenance combinations are recommended as genetic material to be developed in the program of ex-situ conservation as well as tree improvement program for the establishment of best seed sources in the same environment condition as the respected provenances.…”
Get full text

Pediatric Intracochlear Schwannoma: Case Series and Review of the Literature by Enrico Liaci, Maurizio Negri, Francesco Maccarrone, Silvia Piccinini, Enrico Pasanisi, Andrea Bacciu, Filippo Di Lella

“…Neither family history nor genetic signs of neurofibromatosis type II were found. …”
Get full text

Characterization, Quantification, and Molecular Identification of Co-Infection of Canine Parvovirus (CPV-2) Variants in Dogs Affected by Gastroenteritis in Ecuador During 2022–2023... by Anthony Loor-Giler, Silvana Santander-Parra, Sara Castillo-Reyes, Martin Campos, Renán Mena-Pérez, Santiago Prado-Chiriboga, Luis Nuñez

“…Furthermore, it was discovered that in certain samples, a genetic modification at position 297 was connected to the virus’s pathogenicity.…”
Get full text

Ten-Year Persistence of Biologic Drugs in Psoriasis and Its Relationship with Pharmacogenetic Biomarkers by Andrea Rodríguez-Lopez, María Martínez-Sendino, Rocío Prieto-Pérez, Paula Soria-Chacartegui, Eva González-Iglesias, Mario Aparicio-Domínguez, Sonsoles Berenguer-Ruiz, Esteban Daudén, Francisco Abad-Santos

“…In addition, 115 of them were genotyped in a previous study for 173 immune system genetic polymorphisms. <b>Results</b>: The persistence of biologic drugs at 10 years was 25.9% (95% CI: 17.2–34.5%). …”
Get full text

Rheumatoid Arthritis, Circulating Inflammatory Proteins, and Hypertension: A Mendelian Randomization Study by Guobing Jia, Tao Guo, Lei Liu, Chengshi He

“…Our study identifies causal relationships between several genetically determined inflammatory proteins and hypertension, establishing that RA increases hypertension risk, with inflammation partially mediating this effect. …”
Get full text

Gut microbiota and atrial cardiomyopathy by Tingting Sun, Beibei Song, Bo Li

“…Its etiology involves a number of factors, including genetic, infectious, immunologic, and metabolic factors. …”
Get full text

Recent updates of centromere proteins in hepatocellular carcinoma: a review by Zhongyuan Yang, Wenjiao Chen, Yunhui Liu, Yuxin Niu

“…Centromeres are considered special deoxyribonucleic acid (DNA) sequences with highly repetitive sequences that are physically connected to the spindle during cell division, ensuring equal division of genetic material between daughter cells. The numerous proteins that aggregate on this sequence during cell division are called centromere proteins (CENPs). …”
Get full text

Interconnections between BDH1-plasma protein-type 2 diabetes Mellitus: a mediated mendelian randomization analysis using plasma proteomics by Yi-Ying Liu, Yue-Yang Zhang, Qin Wan

“…This study primarily employed the Mendelian Randomization (MR) method, leveraging genetic data from numerous large-scale, publicly accessible genome-wide association studies (GWAS). …”
Get full text

Cystic Fibrosis and Reproductive Outcomes: The Latest Insights into Fertility and Pregnancy by Weronika Małagocka, Karol Zagórski, Mateusz Kozik, Nina Skalska-Dziobek, Karolina Chybowska, Maria Naruszewicz, Przemysław Cetnarowski

“…Reduced fertility may be overcome with assisted reproduction technologies, which also gives an opportunity to do preimplantation genetic tests. CFTR modulators therapy during the pregnancy was described in a small number of studies, but the current experts statement declares that those drugs are probably safe for the infant, and discontinuing this therapy is connected with an increased risk of pulmonary exacerbation in mothers.   …”
Get full text

SF1-specific deletion of the energy sensor AMPKγ2 induces obesity by Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López

“…Results: Our findings reveal that, in contrast to the obesity-protective effect of the genetic deletion of AMPKα subunits, the loss of AMPKγ2 in SF1 neurons leads to a sex-independent and feeding-independent obesity-prone phenotype due to decreased thermogenesis in brown adipose tissue (BAT) and reduced browning of WAT, resulting in lower energy expenditure. …”
Get full text