Identification of a new alphacoronavirus (Coronaviridae: <i>Alphacoronavirus</i>) associated with the greater horseshoe bat (<i>Rhinolophus ferrumequinum</i>) in the south of Europ... by Sergey V. Lenshin, Tatyana V. Vishnevskaya, Alexey V. Romashin, Yulia I. Bulycheva, Oleg I. Vyshemirsky, Sophya A. Solovyeva, Asya K. Gitelman, Alexey S. Pazilin, Dmitry K. Lvov, Ben Hu, Zheng-Li Shi, Sergey V. Alkhovsky

“…Our findings expand the understanding of the distribution of bat alphacoronaviruses and their genetic diversity. We demonstrate the presence of a persistent natural foci of two potentially zoonotic bat coronaviruses, ecologically associated with R. ferrumequinum in the southern European part of Russia.…”
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The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population by Nahide Onsun, Serpil Pirmit, Dilek Ozkaya, Şirin Çelik, Aylin Rezvani, F. Pelin Cengiz, Cigdem Kekik

“…Psoriasis is a multifactorial immune-mediated inflammatory disease triggered by both genetic and environmental factors. The strong association between psoriasis and HLA-C⁎06 allele has been demonstrated in various races. …”
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A new vaccination approach for Salmonellosis employing a multi-epitope vaccine based on live microbial cell factory from Lactococcus lactis by Reyhaneh Sadat Moosavi-Kohnehsari, Mahnaz Jafari-Sohi, Tohid Piri-Gharaghie, Shakiba Tolou-Shikhzadeh-Yazdi, Mona Aghassizadeh-Sherbaf, Romina Hosseinzadeh

“…As a result, the poultry industry needs a powerful oral vaccination platform that uses live bacterial vectors to prevent various Salmonella serotypes. The genetically engineered L. lactis was given orally to birds as a vaccine after a multi-epitope vector was created using a reverse vaccinology technique. …”
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Does Clostridium Perfringens Epsilon Toxin Mimic an Auto-Antigen Involved in Multiple Sclerosis? by Marie-Lise Gougeon, Valérie Seffer, Cezarela Hoxha, Elisabeth Maillart, Michel R. Popoff

“…Many possible causes of MS have been proposed, including genetic factors, environmental triggers, and infectious agents. …”
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Deep-Sea Ecosystems as an Unexpected Source of Antibiotic Resistance Genes by Wei Zhang, Yingdong Li, Yunmeng Chu, Hao Liu, Hongmei Jing, Qianfeng Xia

“…Deep-sea waters (DSW) and trenches had the highest diversity of ARGs, including β-lactams, multidrug resistance genes, and rifamycins. Mobile genetic elements, such as IncQ and RP4 plasmids, were also identified. …”
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METHOD OF QUALIFICATION ESTIMATION AND OPTIMIZATION OF PROFESSIONAL TEAMS OF PROGRAMMERS by A. A. Prihozhy, A. M. Zhdanouski

“…The proposed method is a basis for a genetic algorithm that performs the search for the number, size and staff of groups of programmers which yield a maximum of total qualification. …”
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Prevalence and diversity of Aphanomyces astaci in cambarid crayfish of Pennsylvania: where native and introduced hosts meet by Adam Petrusek, Michaela Mojžišová, Adéla Mikešová, Radka Piálková, David A. Lieb

“…We investigated the distribution, prevalence and genetic variation of A. astaci in Pennsylvania (eastern USA), where multiple native and introduced crayfish species (family Cambaridae) occur. …”
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Identified VCAM1 as prognostic gene in gastric cancer by co-expression network analysis by Wenjuan Li, Hong Gao, Jianjun Liu

“…This study aims to identify genetic variances and potential diagnostic and therapeutic approaches for diverse types of gastric cancer utilizing an extensive dataset. …”
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Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent by Jan Mersmann, Franziska Iskandar, Kathrina Latsch, Katharina Habeck, Vera Sprunck, René Zimmermann, Ralf R. Schumann, Kai Zacharowski, Alexander Koch

“…Genetic or pharmacological ablation of toll-like receptor 2 (TLR2) protects against myocardial ischemia/reperfusion injury (MI/R). …”
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Multi-objective optimization of SUS430C steel turning process using hybrid machine learning and evolutionary algorithm approach by Nguyen Van-Canh, Nguyen Anh-Thang, Pham Ngoc-Linh, Nguyen Thuy-Duong

“…A hybrid approach combining Extreme Gradient Boosting (XGBoost) and Non-dominated Sorting Genetic Algorithm-II (NSGA-II) was employed to optimize three critical machining objectives: surface roughness (Ra), material removal rate (MRR), and tool wear (Vb). …”
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Design and Profit Allocation in Two-Echelon Heterogeneous Cooperative Logistics Network Optimization by Yong Wang, Yingying Yuan, Kevin Assogba, Ke Gong, Haizhong Wang, Maozeng Xu, Yinhai Wang

“…First, a mixed integer linear programing model is introduced to minimize the total operating cost of nonempty coalitions. Thus, the Genetic Algorithm (GA) and the Particle Swarm Optimization (PSO) algorithm are hybridized to propose GA-PSO heuristics. …”
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Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK‐inhibitor‐induced tolerant persister cells in ALK‐fusion‐positive lung cancer... by Koh Furugaki, Takaaki Fujimura, Narumi Sakaguchi, Yasutaka Watanabe, Ken Uchibori, Eisaku Miyauchi, Hidetoshi Hayashi, Ryohei Katayama, Shigeki Yoshiura

“…Cancers can develop resistance to treatment with ALK tyrosine kinase inhibitors (ALK‐TKIs) via emergence of a subpopulation of drug‐tolerant persister (DTP) cells that can survive initial drug treatment long enough to acquire genetic aberrations. DTP cells are thus a potential therapeutic target. …”
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First Detection and Genomic Characterization of Linezolid-Resistant <i>Enterococcus faecalis</i> Clinical Isolates in Bulgaria by Tanya V. Strateva, Preslava Hristova, Temenuga J. Stoeva, Hristina Hitkova, Slavil Peykov

“…Phylogenomic analysis revealed that Efs2503-bg and Efs966-bg are genetically distinct, with a difference of 12,051 single-nucleotide polymorphisms. …”
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Exploring the Orca Predation Algorithm for Economic Dispatch Optimization in Power Systems by Vivi Aida Fitria, Arif Nur Afandi, Aripriharta

“…This research shows that Orca Predation Algorithm consistently does better than other bio-inspired algorithms like Particle Swarm Optimization, Whale Optimization Algorithm, Grey Wolf Optimizer, the Bat Algorithm, Genetic Algorithm and Ant Colony Optimization in terms of minimum cost, average cost, and solution stability. …”
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In-Depth Learning Layout and Path Optimization of Energy Service Urban Distribution Sites under e-Commerce Environment by Kun Wang, Ki-Hyung Bae

“…Algorithms mainly include two-stage hybrid heuristic algorithm of cluster analysis, maximum coverage and genetic algorithm; simulation analysis is conducted to verify the effectiveness of the model and algorithm by data simulation, finally get the integrated optimization plan of distribution center location and routing, and put forward the operation strategy through the result expansion analysis. …”
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Meat quality and fatty acid composition of Nero d’Aspromonte native pigs: effect of rearing system and carcase weight by Meng Peng, Siria Tavaniello, Mengjun Wu, Sanije Zejnelhoxha, Marisa Palazzo, Giulia Grassi, Yongqing Hou, Giuseppe Maiorano

“…In conclusion, obtained results indicate that the Nero d’Aspromonte pig is an interesting genetic type that, when reared in the open air and producing heavier carcases, could provide meat more suitable from the nutritional perspective.…”
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The OXT rs6133010 variant modulates susceptibility to psychiatric symptoms during withdrawal in patients with alcohol dependence by Guanghui Shen, Wei Wang, Yuyu Wu, Xinguang Luo, Kexin Wang, Yu-Hsin Chen, Yimin Kang, Yanlong Liu, Fan Wang, Li Chen

“…While neuroadaptation during withdrawal influences symptoms, the genetic factors behind it have not been thoroughly investigated. …”
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Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab by Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe

“…Fulminant diabetes is an immune endocrinopathy that results from a violent immune attack leading to complete destruction of pancreatic beta cells in genetically predisposed people. We present a rare case of fulminant diabetes precipitated by anti-PD-1 immunotherapy. …”
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Investigating the role of iron status in the development of coeliac disease: a Mendelian randomisation study by Isabel A Hujoel, Margaux Louise Anna Hujoel

“…All three assumptions of MR appeared plausible.Conclusion We found that genetically lower iron levels were associated with an increased risk of coeliac disease. …”
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Genotypic Spectrum in a Cohort of Sri Lankan Patients With Homocystinuria by Hewa Warawitage Dilanthi, Kandana Liyanage Subhashinie Jayasena, Nambage Dona Priyani Dhammika, Neluwa Liyanage Ruwan Indika, Matara Mahavidanage Nishani De Silva, Imalke Kankananarachchi, Pushpa Malkanthi Gardiye Punchihewa, Dharma Irugalbandara, Sabine Schroeder, Kosala Karunaratne, Eresha Jasinge

“…ABSTRACT Homocystinuria due to cystathionine beta‐synthase (CBS) deficiency is a rare metabolic disorder inherited as an autosomal recessive trait. Spectrum of genetic variants in CBS gene and their correlation with the phenotypes of homocystinuria in Sri Lankan patients have not been reported to date. …”
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