Temperature control of shoot growth and floral initiation in apple (Malus × domestica Borkh.) by Ola M. Heide, Rodmar Rivero, Anita Sønsteby

“…Conclusions The results are discussed in relation to the extensive physiological and genetic literature on the subject. We interpret the results as two separate effects of temperature on flowering in apple. …”
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TSC complex decrease the expression of mTOR by regulated miR-199b-3p by Na Zhao, Qiuhong Xiong, Ping Li, Guangxin Chen, Han Xiao, Changxin Wu

“…Abstract The TSC complex formed by TSC1 and TSC2 is the most important upstream negative regulator of mTORC1. Genetic variations in either TSC1 or TSC2 cause tuberous sclerosis complex (TSC) disease which is a rare autosomal dominant disorder resulting in impairment of multiple organ systems. …”
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The mutational landscape of Staphylococcus aureus during colonisation by Francesc Coll, Beth Blane, Katherine L. Bellis, Marta Matuszewska, Toska Wonfor, Dorota Jamrozy, Michelle S. Toleman, Joan A. Geoghegan, Julian Parkhill, Ruth C. Massey, Sharon J. Peacock, Ewan M. Harrison

“…Despite limited within-host genetic diversity, we observed an excess of protein-altering mutations in metabolic genes, in regulators of quorum-sensing (agrA and agrC) and in known antibiotic targets (fusA, pbp2, dfrA and ileS). …”
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Biochemical Behaviours of Salmeterol/Fluticasone Propionate in Treating Asthma and Chronic Obstructive Pulmonary Diseases (COPD) by Hilla Mills, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, Thang Nguyen Van

“…Specific doses are prescribed accurately paying attention to factors like age, gender, race, and genetic makeup since these affect drug metabolisms. …”
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The Impact of Selected Regimens of Chronic HIV‐Antiretroviral Treatment on Glycemic Control Markers and Correlates: A Systematic Review and Meta‐Analysis Protocol by Mlindeli Gamede, Mbulelo Aubrey Sosibo, Nontobeko Gumede, Mluleki Luvuno

“…The etiology of diabetes can be mainly attributed to factors such as genetic susceptibility, unhealthy diets, and chronic medications. …”
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Case Series of Brittle Cornea Syndrome by Taher Eleiwa, Mariam Raheem, Nimesh A. Patel, Audina M. Berrocal, Alana Grajewski, Mohamed Abou Shousha

“…Three cases presented with bluish sclera and extremely thin cornea. Genetic workup was performed and confirmed the diagnosis of Brittle Cornea Syndrome, a rare autosomal recessive disorder characterized by corneal thinning and blue sclera. …”
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A novel mutation, Ile344Asn, in microsomal triglyceride transfer protein abolishes binding to protein disulfide isomerase by Swati Valmiki, Cindy Bredefeld, M. Mahmood Hussain

“…In this study, we report a proband with abetalipoproteinemia who was monitored annually for 10 years in her third decade and had very low plasma lipids and undetectable apoB-containing lipoproteins. Genetic testing revealed biallelic variants in the MTTP gene. …”
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Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome by Federica Tiberio, Martina Salvati, Luca Polito, Giada Tisci, Alessia Vita, Ornella Parolini, Luca Massimi, Lorena Di Pietro, Pierpaolo Ceci, Gianpiero Tamburrini, Alessandro Arcovito, Elisabetta Falvo, Wanda Lattanzi

“…Crouzon syndrome is a rare genetic craniofacial malformation caused by heterozygous gain-of-function mutations in the FGFR2 gene. …”
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Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes by Sungkyoung Choi, Sunghwan Bae, Taesung Park

“…The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. …”
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Calibration of Microscopic Traffic Flow Simulation Models considering Subsets of Links and Parameters by Alexander Paz, Kul Shrestha, Cristian Arteaga, Douglas Baker

“…Traffic volume and speed are the performance measures used in this study, and the methodology is developed without considering the characteristics of a specific traffic flow model. A genetic algorithm was implemented to find a solution to the proposed mathematical program. …”
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New insights into the salt-responsive regulation in eelgrass at transcriptional and post-transcriptional levels by Huan Zhao, Huan Zhao, Xu Dong, Xu Dong, Dazuo Yang, Dazuo Yang, Qingchao Ge, Qingchao Ge, Peng Lu, Peng Lu, Chang Liu, Chang Liu

“…These conserved gene resources may provide targets for genetic engineering to improve the salt tolerance of crops.…”
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A robust multi-objective multi-priodic planning approach to the problem of locating the allocation of organ transplant centers under conditions of uncertainty by Elham Nejati, Mahdi Yousefi Nejad Attari, Asgar Hajibadali

“…On the other hand, due to the rapid growth of the demand for organ transplantation and the lack of resources, the patient's waiting time to complete the transplantation process plays a vital role in the organ transplantation system.Methodology: This study presents a robust bi-objective mathematical model for the location problem of allocating organ transplant centers under uncertainty, which includes the total costs of the organ transplant system as well as the average patient waiting time for organ transplantation, which follows a G/G/m queuing system.Findings: To solve this model, the Non-Dominated Sorting Genetic Algorithm II (NSGA-II) has been used. Finally, the applicability of this model and the efficiency of the mentioned algorithm compared to the defined indicators have been shown through numerical experiments.Originality/Value: Since each organ can spend a certain amount of time outside the body and there is a possibility of corruption or a decrease in the quality of the transplant, the time between the organ leaving the body and the completion of the transplant operation plays an essential role in the transplant system.…”
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The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population by Guoda Ma, Haiyang Wang, Guixi Mo, Lili Cui, You Li, Yiming Shao, Xin Liu, Yuliu Xie, Jia Li, Jiawu Fu, Hua Tao, Bin Zhao, Liangqing Zhang, Keshen Li

“…In the survivors, the PPAR-γ Pro12Ala genotype was significantly associated with decreased disease severity and recovery time (all P<0.001). Thus, genetic polymorphism is thought to play a role in the development and outcome of sepsis.…”
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Construction and efficacy of recombinant Newcastle disease virus co-expressing VP2 and VP3 proteins of very virulent infectious bursal disease virus by Tongfei Liu, Lin Lin, Yun Pan, Xiaoling Lin, Ming Liang, Guanming Shao, Keyu Feng, Yaxin Liu, Xinheng Zhang, Qingmei Xie

“…The recombinant Newcastle disease virus (rNDV) expressing both VP2 and VP3 (rNDV-VP2-VP3) was generated and compared to rNDV expressing VP2 alone (rNDV-VP2). The genetic stability and growth pattern of rNDV were evaluated and its immunogenicity was assessed in specific pathogen free (SPF) chickens. rNDV-VP2-VP3 vaccines induced higher levels of neutralising antibodies, no damage to immune organs, and significantly lower viral loads in the bursa of the falciparum. rNDV-VP2 group showed partial protection, while the placebo group exhibited severe lesions and higher mortality, suggesting that the vaccine was effective in preventing IBDV-induced damage. …”
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A Novel Nonsense Mutation of POU4F3 Gene Causes Autosomal Dominant Hearing Loss by Chi Zhang, Mingming Wang, Yun Xiao, Fengguo Zhang, Yicui Zhou, Jianfeng Li, Qingyin Zheng, Xiaohui Bai, Haibo Wang

“…Routine examination of POU4F3 is necessary for the genetic diagnosis of hereditary hearing loss in the future.…”
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Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancer by Yankui Liu, Anjie Chen, Yufan Wu, Jiang Ni, Rong Wang, Yong Mao, Ning Sun, Yuanyuan Mi

“…MTCH2 is also upregulated in locally treated CRPC tissue and various primary human CRPC cells. Using genetic silencing via shRNA and knockout (KO) through the CRISPR-sgRNA approach, we showed that the depletion of MTCH2 impaired mitochondrial function, resulting in a reduced oxygen consumption rate, diminished complex I activity, and decreased ATP levels, mitochondrial depolarization, and increased reactive oxygen species production in primary CRPC cells. …”
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Unraveling TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR Transcription Factors in Safflower: A Blueprint for Stress Resilience and Metabolic Regulation by Lili Yu, Xintong Ma, Mingran Dai, Yue Chang, Nan Wang, Jian Zhang, Min Zhang, Na Yao, Abdul Wakeel Umar, Xiuming Liu

“….), a versatile medicinal and economic crop, harbors untapped genetic resources essential for stress resilience and metabolic regulation. …”
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A fungus-eat-fungus world: Digitopodium, with particular reference to mycoparasites of the coffee leaf rust, Hemileia vastatrix by Adans A. Colmán, Harry C. Evans, Sara S. Salcedo-Sarmiento, Uwe Braun, Kifle Belachew-Bekele, Robert W. Barreto

“…These isolates were found to be morphologically and genetically identical to H. tectonae, described previously from Brazil. …”
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Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents by Valeria Calcaterra, Valeria Calcaterra, Francesca Penagini, Virginia Rossi, Luisa Abbattista, Alice Bianchi, Massimiliano Turzi, Lucia Cococcioni, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti

“…A thyroid function monitoring and future research exploring the genetic and immunologic connections are essential to enhance our understanding of the interrelation between IBD and thyroid disorders.…”
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Priapism in a Child from Homocystinuria from Methylenetetrahydrofolate Reductase MTHFR (C677T) Mutation by Ameer Kakaje, Ammar Fadel, Osama Hosam Aldeen, Othman Hamdan

“…Doppler ultrasonography found decreased cavernous blood flow, and warm 0.9% saline lavage of the cavernosa was indicated and successfully treated the priapism. Genetic testing for the homozygous MTHFR (C677T) mutation was later confirmed, and warfarin was indicated. …”
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