Optimizing the Long-Term Operating Plan of Railway Marshalling Station for Capacity Utilization Analysis by Wenliang Zhou, Xia Yang, Jin Qin, Lianbo Deng

“…Secondly, an algorithm is designed to solve this model based on genetic algorithm (GA) and simulation method. It divides the plan of whole planning horizon into many subplans, and optimizes them with GA one by one in order to obtain a satisfactory plan with less computing time. …”
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Research on the optimization method of emergency material post transportation model based on bi-level programming by Haixia ZHOU, Yurong MEI, Furu LYU, Zhixin SUN

“…Emergency logistics is a special logistics activity that protects the need of personnel,materials and funds in the event of a major emergency.In the post transportation model of emergency supplies,how to quickly and accurately deliver a large amount of rescue materials to the place of need is a huge challenge to emergency logistics.The logistics cost and the logistics time in the entire logistics process could be minimized by the bi-level planning method while meeting the demand for emergency supplies at the demand point.The bi-level programming model was constructed with the minimum logistics cost of the upper layer and the shortest logistics time of the bottom layer as the goal,and a hybrid tabu search genetic algorithm (HTSGA) was designed to solve the model,which solved the problem of emergency logistics transportation route optimization after the disaster.Finally,the experimental result comparison verified the effectiveness of the model and algorithm.…”
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An elementary approach to modeling drug resistance in cancer by Cristian Tomasetti, Doron Levy

“…In this work we consider the problem ofdrug resistance in cancer, focusing on random genetic point mutations.Most previous works on mathematical models of such drug resistancehave been based on stochastic methods. …”
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Multiobjective Optimization Method for Energy-Saving Design of Green Buildings by Yuanting Yang, Fengxiang Lu, Lan Qing

“…The results show that compared to classic intelligent optimization design algorithms such as nondominated sorting genetic algorithm II (NSGA-II), the proposed method reduces discomfort time by 1.29% while only increasing energy consumption by 0.61%.…”
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Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review by Jie Ji, Chen Gong, Gengxi Lu, Junhang Zhang, Baoqiang Liu, Xunan Liu, Junhao Lin, Patrick Wang, Biju B. Thomas, Mark S. Humayun, Qifa Zhou

“…Furthermore, the review underscores the potential of sonogenetics in vision restoration, which involves leveraging pharmacological and genetic manipulations to inhibit or enhance the expression of related mechanosensitive channels, thereby modulating the strength of the ultrasound response. …”
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Biomarkers for Hepatocellular Carcinoma by Tara Behne, M. Sitki Copur

“…Increased understanding of cancer biology and technological advances have enabled identification of a multitude of pathological, genetic, and molecular events that drive hepatocarcinogenesis leading to discovery of numerous potential biomarkers in this disease. …”
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PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways by Jordi Camps, Anabel García-Heredia, Anna Rull, Carlos Alonso-Villaverde, Gerard Aragonès, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Jorge Joven

“…This article reviews the state of knowledge on PON1 biochemistry and function, the influence of genetic variation, and the regulation of PON1 expression by pharmaceutical compounds that increase PPAR activity. …”
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Case Report: Two-month-old infant with PHACE syndrome: facial hemangioma and severe complex coarctation of the aorta by Sánchez-Ortiz David, Sánchez-Ortiz David, Deiros-Bronte Lucía, De la Hoz-Marañón Lucía, Feito-Rodríguez Marta, Rey-Lois Juvenal, Salas-Mera Diana, Labrandero-De Lera Carlos, López-Gutiérrez Juan Carlos, Gutiérrez-Larraya Federico

“…The complementary diagnostic studies, their surgical correction, and their progression are described.DiscussionGiven the rarity of the syndrome (the PHACE Syndrome International Clinical Registry and Genetic Repository has over 270 enrolled individuals) and the importance of early diagnosis of some anomalies it comprises, particularly cardiovascular anomalies, dissemination is considered crucial for general and pediatric cardiologists.…”
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Familial Multiple Sclerosis with Repetitive Relapses of Manic Psychosis in Two Patients (Mother and Daughter) by Pedro J. Modrego, Jaime Ferrández

“…We focused discussion on whether there may be a common genetic susceptibility to both illnesses or whether MS caused psychiatric manifestations. …”
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Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer by Tatiane da Silva Fernandes, Bryan M. Gillard, Tao Dai, Jeffrey C. Martin, Kanita A. Chaudhry, Scott M. Dugas, Alyssa A. Fisher, Pia Sharma, RongRong Wu, Kristopher M. Attwood, Subhamoy Dasgupta, Kazuaki Takabe, Spencer R. Rosario, Anna Bianchi-Smiraglia

“…Analysis of publicly available datasets reveals elevated IMPDH2 expression to associate with worse overall TNBC prognosis in the clinic, including lower recurrence-free survival post adjuvant/neoadjuvant therapy. Importantly, both genetic depletion and pharmacological inhibition of IMPDH2 leads to reduction of pro-tumorigenic phenotypes in multiple doxorubicin-resistant TNBC models, both in vitro and in vivo. …”
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Hubble Bubble Equals Trouble: The Hazards of Water Pipe Smoking by Jacob Urkin, Rivka Ochaion, Aya Peleg

“…The health hazards that the Narghile smoker is exposed to include interference with oxidation, damage to genetic compounds, increased risk of developing malignancies, infectious diseases, damage to the fetus and newborn, and exposure to commonly abused chemicals. …”
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Selecting the objective function during the inverse identification of the parameters of a material model of concrete by F. Hokes, J. Kala

“…The proposed article brings a study of the influence of the different formulations of the objectives functions to achieving optimum in the inverse analysis using genetic algorithm. The numerical part of the study was performed in the ANSYS computational system with use of multiPlas library of elasto-plastic material models from which the model based on formulations of Menetrey and Willam was chosen.…”
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A modern approach to the treatment of plaque psoriasis by Drvar Daniela Ledić, Vlahinić Tomislav, Maleš Željan, Turčić Petra, Čeović Romana

“…The etiopathogenesis of the disease is multifactorial, the key factors being genetic predisposition combined with immunological disorders, environmental factors and skin barrier damage. …”
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Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals? by Joseph A. Houmard, Walter J. Pories, G. Lynis Dohm

“…Together, these findings are indicative of a dysfunctional global metabolic program with severe obesity which is of an epigenetic or genetic origin. Weight loss via gastric bypass surgery can “turn off” and/or correct components of this metabolic program as insulin sensitivity is restored; however, the impairment in FAO in skeletal muscle remains evident. …”
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Role of Leukotrienes on Protozoan and Helminth Infections by Alexandre P. Rogerio, Fernanda F. Anibal

“…Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites. …”
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Assessment of Transformed Properties In Vitro and of Tumorigenicity In Vivo in Primary Keratinocytes Cultured for Epidermal Sheet Transplantation by A. Thépot, A. Desanlis, E. Venet, L. Thivillier, V. Justin, A. P. Morel, F. DeFraipont, M. Till, V. Krutovskikh, M. Tommasino, O. Damour, P. Hainaut

“…The question addressed here is to determine whether the culture process may induce cellular, molecular, or genetic alterations that might increase the risk of cellular transformation. …”
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METHOD FOR MODIFYING PROFILE OF CYCLOIDAL WHEEL CONSIDERING COMPENSATION FOR ELASTIC DEFORMATION by QIN ZhengZheng, WANG Quan, ZHAO DaXing, WANG Jun, ZENG LiLei

“…And the mathematical model of the profile modification of the cycloid with elastic deformation characteristics was established,which was solved by genetic algorithm and compared with the modification method without considering elastic deformation.The results show that compared with the modification method without considering elastic deformation,the fitting degree of the actual working tooth profile and the angle modification tooth profile is improved to 1. 52 times,and the contact force of the tooth surface is reduced to8. 27%,thus verifying the rationality and feasibility of the method.…”
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CONTACT STRESS ANALYSIS AND OPTIMIZATION OF DOUBLE SHOCK SLEEVE MOVABLE TOOTH by SHEN HaiTao, AN ZiJun

“…In this paper,the logarithmic generatrix modification method and genetic optimization algorithm are used to optimize the structure of sleeve movable teeth. …”
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RNA Splicing: A New Player in the DNA Damage Response by Silvia C. Lenzken, Alessia Loffreda, Silvia M. L. Barabino

“…It is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations. However, the molecular basis of genomic instability in cancer is still partially understood. …”
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Alternative Splicing Programs in Prostate Cancer by Claudio Sette

“…Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. The genetic and phenotypic heterogeneity of this type of cancer renders its diagnosis and cure particularly challenging. …”
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