MPN/MDS OVERLAP SYNDROME ANTICIPATED BY A SEVERE BLEEDING DIATHESIS: HYPOTHESIS OF A PRE-EXISTING PLATELET DISORDER by Paola Ranalli, Stefano Baldoni, Daniela Bruno, Mauro Di Ianni

“…This case report underlines the importance of genetic testing in case of patient with documented platelet function disorder, including both mutations associated with inherited platelet disorders and germline mutations more strictly predisposing to Myeloid Neoplasms. …”
Get full text

Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth by Victoria Hamrahi, Michael R. Hamblin, Walter Jung, John B. Benjamin, Kasie W. Paul, Alan J. Fischman, Ronald G. Tompkins, Edward A. Carter

“…We used Gram-negative bacteria (Pseudomonas aeruginosa and Proteus mirabilis) that were genetically engineered to be bioluminescent, which allowed for noninvasive, sequential optical imaging of the extent and severity of the infection. …”
Get full text

Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations by Masahiro Murakami

“…Breakdown of these signaling systems results in pathological hyperpermeability and/or genetic vascular abnormalities such as vascular malformations, ultimately progressing to hemorrhage and edema. …”
Get full text

Planar ESPAR Array Design with Nonsymmetrical Pattern by Means of Finite-Element Method, Domain Decomposition, and Spherical Wave Expansion by Jesús García, Juan F. Izquierdo, Jesús Rubio, Miguel A. González, Juan Zapata

“…This procedure has been firstly validated by analyzing an array of monopoles on a ground plane, and then it has been applied to synthesize a prescribed radiation pattern optimizing the reactive loads connected to the feeding ports of the array of circular patches by means of a genetic algorithm.…”
Get full text

The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape by Yasuto Araki, Toshihide Mimura

“…The activation of RA synovial fibroblasts (SFs), also called fibroblast-like synoviocytes (FLS), contributes significantly to perpetuation of the disease. Genetic and environmental factors have been reported to be involved in the etiology of RA but are insufficient to explain it. …”
Get full text

Allgrove syndrome in endocrinology: Difficulties of diagnosis and treatment features. Case report by Uliana V. Buyvalenko, Anna R. Levshina, Anna K. Eremkina, Kseniya A. Komshilova, Nadezhda M. Platonova

“…Neurological dysfunction from the involvement of central or autonomic nervous systems is also common with Allgrove syndrome observed during the adolescent period. Genetic analysis and detection of the AAAS gene mutation is the main step in the diagnosis of the syndrome. …”
Get full text

Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development by Cynthia Garcia, David H. Gutmann

“…As such, tumors arise when cells acquire genetic mutations that allow them to escape the normal growth constraints. …”
Get full text

Organisational and economic aspects of the archives digitalisation of the State Film Fund of the Russian Federation by M. I. Kosinova, A. A. Gasilina

“…The study used the following methods: historical and genetic analysis, descriptive analysis of literature and media materials, qualitative content analysis of documents, reports and other materials, comparative analysis, secondary analysis of public opinion surveys and statistical data. …”
Get full text

Parkinson's Disease: Clinical Signs and Symptoms, Neural Mechanisms, Positron Emission Tomography, and Therapeutic Interventions by K. L. Leenders, W. H. Oertel

“…The cause of the disease is unknown, but recently involvement of genetic factors is being researched. Positron emission tomography (PET) allows in vivo determination of striatai dopaminergic activity. …”
Get full text

Iterative GA Optimization Scheme for Synthesis of Radiation Pattern of Linear Array Antenna by Sarayoot Todnatee, Chuwong Phongcharoenpanich

“…This research has proposed the iterative genetic algorithm (GA) optimization scheme to synthesize the radiation pattern of an aperiodic (nonuniform) linear array antenna. …”
Get full text

Initial/Final Tone Agreement in Ekegusii (Bantu; Kenya) by Larry M. Hyman

“…I first provide an overview of the phenomenon in Ekegusii (Kenya), and then show that a relative construction in geographically and genetically distant Grassfields Bantu languages of Cameroon can help us understand both the nature and history of the more evolved situation seen in Ekegusii. …”
Get full text

Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish Native by Hugh J Freeman

“…These patients are the first reported natives in Canada with celiac disease, a disorder believed to be genetically based but dependent on environmental factors for its clinical expression. …”
Get full text

Research on Taxi Pricing Model and Optimization for Carpooling Detour Problem by Wei Zhang, Ruichun He, Yong Chen, Mingxia Gao, Changxi Ma

“…This paper builds a multiobjective optimization model for solving the taxi carpooling with detour problem and designs a genetic algorithm to determine a fair pricing scheme for riders and drivers. …”
Get full text

The role of immunity in insulin resistance in patients with polycystic ovary syndrome by Qixuan Zhang, Zhe Yang, Xiangyang Ou, Mengying Zhang, Xiangyu Qin, Gengxiang Wu

“…While the precise pathogenesis of PCOS remains unclear, it is now recognized that genetic, endocrine, and metabolic dysregulations all contribute significantly to its onset. …”
Get full text

RNA splicing: a split consensus reveals two major 5′ splice site classes by Matthew T. Parker, Sebastian M. Fica, Gordon G. Simpson

“…Separating the human 5′ splice site consensus into its two major constituents can help us understand fundamental features of eukaryote genome architecture and splicing mechanisms and inform treatment design for diseases caused by genetic variation affecting splicing.…”
Get full text

Designing a Multi-Objective Closed-loop Supply Chain Mathematical Model with Supplier Selection Approach and considering Discount by Esmat Saadi, kiamars fathi, Reza Radfar

“…The presented model generates Pareto solutions using two proposed meta-heuristic algorithms, multi objective particle swarm optimization and non-dominated sorting genetic algorithm and combination of the two. To compare the performance of the solution methods, five criteria are defined and the numerical results show the efficiency and quality of the proposed hybrid algorithm.…”
Get full text

L’hyperactivité/TDAH : un analyseur de l’apport des neurosciences aux pratiques médiatiques, éducatives et à la formation des travailleurs sociaux by Sébastien PONNOU

“…We focused our analysis on the neurologic and genetic risk factors for ADHD, and on the effects of drugs on school achievement. …”
Get full text

“History Lives in the Body”: The Body/Land/History Triad in Linda Hogan’s The Woman Who Watches Over the World by Joanna ZIARKOWSKA

“…Hogan offers an understanding of history expressed in terms of geographical locations as well as bodily experiences and sensations that are remembered, passed on and inherited in the same way genetic material is transmitted from one agent to another. …”
Get full text

Multi-objective Optimization Design of an Aviation Split Path Transmission System by Zhao Ning, Fu Chenxi, Zhao Yongzhi, Fu Bibo

“…The promoting the safety performance and lightweight are considered as the objectives,a multi-objective optimization design of an aviation split path transmission system is conducted.To measure the safety performance of the system,gear contact and bending fatigue strength are computed.Afterwards,a multi-objective optimization model that includes maximum safety factors and minimum mass is developed,with the system parameters selected as design variables.Considering the system requirements for load sharing,a dynamics model of the split path transmission system is established so that the load sharing characteristics can be quantifiably measured and restricted.Non-dominated Sorting Genetic Algorithm II（NSGA-II）is adopted to solve the model.The results show that the method promoted can effectively improve the safety performance and reduce the weight at the same time.…”
Get full text

Grey Zone Lymphomas: Lymphomas with Intermediate Features by Sylvia Hoeller, Christiane Copie-Bergman

“…The current classification of lymphoid neoplasms is based on clinical information, morphology, immunophenotype, and molecular genetic characteristics. Despite technical and scientific progress, some aggressive B-cell lymphomas with features overlapping between two different types of lymphomas remain difficult to classify. …”
Get full text