Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy by Hassan Tariq, Syeda Zunaira Bukhari, Ruibing An, Jian Dong, Ayesha Ihsan, Muhammad Rizwan Younis

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Engineering of SauriCas9 with enhanced specificity by Xiaoqi Zhang, Chen Tao, Miaomiao Li, Sufang Zhang, Puping Liang, Yan Huang, Huihui Liu, Yongming Wang

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Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix‐assisted laser desorption/ionization‐time‐of‐flight mass spectrometry and nanoscale liquid chromatograp... by Sekkarin Ploypetch, Apisit Pornthummawat, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sabrina Wahyu Wardhani, Sitthichok Lacharoje, Somporn Techangamsuwan

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CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study by Jiang N, Wang Q, Hu Z, Tian X

“…Nizhou Jiang,1,* Quanxiang Wang,2,* Zhenxin Hu,3,* Xiliang Tian1 1Department of Spine Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 2Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 3Department of Spine Surgery, Peking University Fourth School of Clinical Medicine, Beijing Jishuitan Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiliang Tian, Department of Spine Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China, Email tianxiliang1983@163.comBackground: Intervertebral disc degeneration (IVDD) is a common chronic degenerative disease with a complex etiology involving genetic and environmental factors. However, the genetic pathogenesis and key driving factors of IVDD remain largely unknown.Methods: In this study, we combined MR with transcriptomic sequencing to identify key pathogenic genes implicated in IVDD. …”
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Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in Andrographis paniculata by Shao-Fen Jian, Shao-Fen Jian, Shao-Fen Jian, Yan-Fen Huang, Yan-Fen Huang, Yan-Fen Huang, Dong-Liang Chen, Chu Zhong, Chu Zhong, Chu Zhong

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Weighted Gene Co-Expression Network of Growth Differentiation-Related lncRNAs and mRNAs in Plectropomus leopardus by Jin GAO, Jinye LIU, Fuxiao CHEN, Yongbo WANG, Shuyuan FU

“…However, the quality of growth traits serves as a critical indicator for evaluating the economic value of fish aquaculture. Influenced by both genetic predispositions and environmental factors, these traits warrant investigation into the genetic mechanisms and regulatory strategies governing growth-related characteristics in farmed fish. …”
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Two-Echelon Multidepot Logistics Network Design with Resource Sharing by Siyu Luo, Yong Wang, Jinjun Tang, Xiangyang Guan, Maozeng Xu

“…Integrating a customer clustering algorithm, a greedy algorithm, and an improved nondominated sorting genetic algorithm-II (Im-NSGA-II), a hybrid method is then designed to handle the 2E-CMDPDTW model. …”
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Genome-wide identification and expression analysis of the PIN gene family in the pepper pedicel abscission zone and during root development by HE Lei, YAN Xi, LAI Wei, LIU Chongzheng, YANG Hong, HE Jianwen

“…These genes hold significant potential as candidates for breeding pepper varieties with improved ease of de-stemming and for enhancing genetic traits related to root systems.…”
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Rapid diversification of St-genome-sharing species in wheat grasses (Triticeae: Poaceae) accompanied by diversifying selection of chloroplast genes by Li-Na Sha, Ning Chen, Shi-Yong Chen, Yue Zhang, Yi-Ran Cheng, Dan-Dan Wu, Yi Wang, Hou-Yang Kang, Hai-Qin Zhang, Xiao Ma, Yong-Hong Zhou, Xing Fan

“…Molecular tests of evolution and gene expression further indicated that radiation within the accelerated group has been accompanied by adaptive genetic changes in a few chloroplast-encoded genes directly or indirectly related to photosynthesis. …”
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The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy by Eduardo Spinedi, Daniel P. Cardinali

“…., chronodisruption) and genetic/epigenetic factors may also play relevant roles in syndrome development. …”
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Disruption of seasonal influenza circulation and evolution during the 2009 H1N1 and COVID-19 pandemics in Southeastern Asia by Zhiyuan Chen, Joseph L.-H. Tsui, Jun Cai, Shuo Su, Cécile Viboud, Louis du Plessis, Philippe Lemey, Moritz U. G. Kraemer, Hongjie Yu

“…However, the seasonal influenza migration network within Southeastern Asia remains unclear, including how pandemic-related disruptions altered this network. We leveraged genetic, epidemiological, and airline travel data between 2007-2023 to characterise the dispersal patterns of influenza A/H3N2 and B/Victoria viruses both out of and within Southeastern Asia, including during perturbations by the 2009 A/H1N1 and COVID-19 pandemics. …”
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Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelinationResearch in context by Jian Huang, Jinyi Che, Michelle Z.L. Kee, Ai Peng Tan, Evelyn C. Law, Patricia Pelufo Silveira, Irina Pokhvisneva, Sachin Patel, Keith M. Godfrey, Lourdes Mary Daniel, Kok Hian Tan, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Dennis Wang, Jonathan Yinhao Huang

“…Our findings suggested a shared genetic basis between obesity and language development rather than a causal effect of obesity on language development. …”
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Detection and characterization of bovine hepacivirus in cattle and sheep from Hulunbuir, northeastern China by Jingge Ma, Jingge Ma, Zhiwei Wei, Liang Li, Wei Wang, Ziyan Liu, Ziyan Liu, Ning Liu, Feng Wei, Xiangyu Zheng, Zedong Wang

“…BackgroundBovine hepacivirus (BovHepV) is a recently identified member of the expanding genus Hepacivirus within the family Flaviviridae. However, the genetic diversity, geographical distribution, and host range of the virus remains poorly understood.MethodsIn this study, serum samples from cattle and sheep were obtained in Hulunbuir and pooled to establish RNA libraries, which were then analyzed using transcriptome sequencing. …”
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Divergent Cotton leaf curl Multan betasatellite and three different alphasatellite species associated with cotton leaf curl disease outbreak in Northwest India. by Kajal Kumar Biswas, Nenavath Balram, Marimuthu Elangovan, Supratik Palchoudhury, Utpal Kumar Bhattacharyya, Halima Khatoon, Shilpi Aggarwal, Shruti Godara, Pradeep Kumar, Satish Kumar Sain, Rupesh Arora, Sibnarayan Datta

“…The present study indicated that the betasatellite and alphasatellite molecules associated with CLCuD-begomovirus complex in Northwest India are genetically diverse.…”
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Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients by YongWei Jiang, Liang Ma, ChengWu Han, Qian Liu, Xiao Cong, YaPing Xu, TingTing Zhao, Ping Li, YongTong Cao

“…Diabetic nephropathy (DN) is one of the major chronic complications of diabetes. Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN. …”
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TT Mutant Homozygote of Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children by Jung Ran Choi, In-Su Kwon, Dae Young Kwon, Myung-Sunny Kim, Myoungsook Lee

“…We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. …”
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High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience by Veronica González‐Calle, Paula Rodriguez‐Otero, Maria J. Calasanz, Manuela Guijarro, Joaquin Martínez‐López, Laura Rosiñol, Miguel T. Hernández, Ana I. Teruel, Mercedes Gironella, Albert Oriol, Javier de laRubia, Ana P. González‐Rodríguez, Joan Bargay, Felipe deArriba, Luis Palomera, Marta‐Sonia González‐Pérez, Anna Sureda, Enrique Ocio, Juan J. Lahuerta, Joan Bladé, Jesus F. San Miguel, Maria V. Mateos, Norma C. Gutiérrez

“…The frequency of genetic alterations detected were as follows: del(17p) in 8%, t(4;14) in 12%, t(14;16) in 3%, +1q in 43%, and del(1p) in 8%. …”
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In-depth Analysis of IS6110 Genomic Variability in the Mycobacterium tuberculosis Complex by Jessica Comín, Jessica Comín, Isabel Otal, Isabel Otal, Isabel Otal, Sofía Samper, Sofía Samper, Sofía Samper

“…The aim of this work was to determine the intra- and inter-strain genetic conservation of this element in the MTBC. …”
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Development and implementation of a digiphysical screening model with nationwide reach to diagnose familial hypercholesterolemia by Karin Littmann, Gustav Kindborg, Matthias Lidin, Linda Mellbin, Daniel Eriksson Hogling, Jonas Brinck

“…Selective screening was performed in 2867 patients with coronary artery disease, 355 (12.4%) were identified with increased risk for FH and underwent a genetic test. Of these, 153 (3.8%) had a genetic test result and 52 (1.8%) were diagnosed with FH. …”
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The prognostic and immunomodulatory role of the MMR system in patients with stomach adenocarcinoma by Zhihui Tian, Lili Yang, Rong Yang, Wenhui Yang

“…Moreover, differential MMR genetic expression levels were not significantly correlated with the clinical stages of STAD. …”
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