Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease, which affects the structure of heart muscle tissue. …”
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Identification of candidate genes for leaf size by QTL mapping and transcriptome sequencing in Brassica napus L by Fengjie Cheng, Yuwen Wang, Aoyi Peng, Shuyu Li, Jun Chen, Xiaoxiao Zheng, Jie Xiong, Ge Ding, Bingchao Zhang, Wen Zhai, Laiqiang Song, Wenliang Wei, Lunlin Chen

“…Abstract Leaf is the main photosynthetic organ at the seedling stage of rapeseed and leaf size is a crucial agronomic trait affecting rapeseed yield. Understanding the genetic mechanisms underlying leaf size is therefore important for rapeseed breeding. …”
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Tracing Mechanism of Sports Competition Pressure Based on Backpropagation Neural Network by Huayu Zhao, Shaonan Liu

“…Analyzing the sources of stress and influencing factors of athletes can find measures to relieve and reduce stress and provide theoretical reference for the regulation of athletes’ competition pressure. Based on genetic algorithm and neural network theory, this paper proposes a method of tracing the sports competition pressure based on genetic algorithm backpropagation (BP) neural network to solve the problem that traditional neural network learning algorithm is slow and easy to fall into local minimum. …”
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CRISPR-Cas9 in Cardiovascular Medicine: Unlocking New Potential for Treatment by Klaudia Bonowicz, Dominika Jerka, Klaudia Piekarska, Janet Olagbaju, Laura Stapleton, Munirat Shobowale, Andrzej Bartosiński, Magdalena Łapot, Yidong Bai, Maciej Gagat

“…Cardiovascular diseases (CVDs) remain a significant global health challenge, with many current treatments addressing symptoms rather than the genetic roots of these conditions. The advent of CRISPR-Cas9 technology has revolutionized genome editing, offering a transformative approach to targeting disease-causing mutations directly. …”
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From Nonfunctioning Adrenocortical Cancer to Biochemically Silent Paraganglioma Associated with SDHB Mutation: An Uncommon Presentation of a Patient with a Retroperitoneal Mass by Izabella Freitas, Anna Albuquerque, Luiz de Marco, null Eduardo, José Renan Melo, Juliana Drummond, Beatriz Rocha

“…The indolent course of the disease and minimal impact on the patient’s performance status led to a genetic evaluation which resulted in the identification of a germline mutation in the succinate dehydrogenase complex subunit B (SDHB). …”
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Metabolic engineering of Priestia megaterium for 2’-fucosyllactose production by Bu-Soo Park, Jihee Yoon, Jun-Min Lee, Sang-Hyeok Cho, Yoojeong Choi, Byung-Kwan Cho, Min-Kyu Oh

“…Future studies could explore additional genetic modifications and optimization of fermentation conditions of the strain to further enhance 2’-FL yield and scalability.…”
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Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients by Mónica Escamilla-Tilch, Iris Estrada-García, Julio Granados, Roberto Arenas-Guzmán, Rosalio Ramos-Payan, Thalía Gabriela Pérez-Suárez, Ma. Isabel Salazar, Riky Luis Pérez-Lucas, Sergio Estrada-Parra, Nora Magdalena Torres-Carrillo

“…Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. …”
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A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse by Craig Robert Wright, Giselle Larissa Allsopp, Alex Bernard Addinsall, Natasha Lee McRae, Sofianos Andrikopoulos, Nicole Stupka

“…Given that SEPS1 is highly expressed in skeletal muscle, we investigated whether the genetic reduction of Seps1 exacerbated inflammation in the mdx mouse. …”
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Growth, Water Relations, and Photosynthetic Activity Are Associated with Evaluating Salinity Stress Tolerance of Wheat Cultivars by Abeer Hamdy Elhakem

“…Consequently, we recognized Sakha 69 as a salt-tolerant cultivar that may be used as parents in breeding programs for new cultivars with enhanced salt tolerance and for further genetic investigations to reveal the genetic strategies controlling the response of salinity stress in the wheat plant.…”
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Autoinflammatory Bone Diseases by Fatih Haşlak, Nergis Akay, Ümit Gül, Aybüke Günalp, Elif Kılıç Könte, Sezgin Şahin, Özgür Kasapçopur

“…In such patients, the diagnostic process, which encompasses imaging and genetic studies, should be initiated promptly.…”
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Identification of Maize Kernel Varieties Using LF-NMR Combined with Image Data: An Explainable Approach Based on Machine Learning by Chunguang Bi, Xinhua Bi, Jinjing Liu, He Chen, Mohan Wang, Helong Yu, Shaozhong Song

“…The precise identification of maize kernel varieties is essential for germplasm resource management, genetic diversity conservation, and the optimization of agricultural production. …”
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The Wilson's disease - etiology, symptoms in various organs, diagnosis, treatment, prognosis by Patryk Graczyk, Paulina Klaudia Kwaśniewska, Anna Wilewska, Kinga Borowiec, Agnieszka Borowiec, Julia Biernikiewicz, Konstanty Alabrudziński, Milena Biernikiewicz, Bartosz Pomirski, Agata Pomirska

“…Introduction: Wilson disease (WD) is a genetic disorder of copper metabolism caused by ATP7B gene mutations, impairing copper excretion and leading to copper accumulation in organs. …”
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Redefining bladder cancer treatment: innovations in overcoming drug resistance and immune evasion by Peng Huang, Jie Wang, Zongze Yu, Jiaan Lu, Zhou Sun, Zhigui Chen

“…It is genetic mutation, especially in both low- and high-grade tumors, that, alongside epigenetic modifications, plays a considerable role in tumor aggressiveness and drug resistance. …”
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Genomic prediction of forage nutritive value in perennial ryegrass by Agnieszka Konkolewska, Michael Dineen, Rachel Keirse, Patrick Conaghan, Dan Milbourne, Susanne Barth, Aonghus Lawlor, Stephen Byrne

“…Abstract Background Despite its importance to animal production potential, genetic gain for forage nutritive value has been limited in perennial ryegrass (Lolium perenne L.) breeding. …”
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Orchard: Building large cancer phylogenies using stochastic combinatorial search. by Ethan Kulman, Rui Kuang, Quaid Morris

“…Phylogenies depicting the evolutionary history of genetically heterogeneous subpopulations of cells from the same cancer, i.e., cancer phylogenies, offer valuable insights about cancer development and guide treatment strategies. …”
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Relationship among Tobacco Habits, Human Papilloma Virus (HPV) Infection, p53 Polymorphism/Mutation, and the Risk of Oral Squamous Cell Carcinoma by Neha Gupta, Gargi Yumnam, Chetan Sharma, Avani Patel, Ripudaman Sharma, Sachin Dev, Mahesh Ghadage

“…Strategies focusing on tobacco cessation, HPV vaccination, and genetic screening may help mitigate OSCC risk in susceptible populations.…”
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Assessment of Cytotoxicity and Genotoxicity Potential of Effluents from Bahir Dar Tannery Using Allium cepa by Tayachew Admas, Bizuayehu Kerisew

“…Tannery effluent plays a significant role in increasing pollution in the environment; in particular, it contains toxic heavy metals which cause toxic effects on plant genetic materials. Among tannery effluent chemicals, chromium and lead have cytotoxicity and genotoxicity potentials on Allium cepa. …”
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SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY by Diego A Vargas-Hernández, Adriana Catalina Uscategui-Ruiz, Andrés Jesus Prada-Rueda, Consuelo Romero-Sánchez

“…Our results reflect the absence of redirection of these patients to genetic counseling.   …”
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Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome by Linjun Chen, Lin Wang, Lei Chen, Fangyuan Wang, Fei Ji, Wei Sun, Hui Zhao, Weiju Han, Shiming Yang

“…However, the genetic pathway affecting the development of stria vascularis is not fully illustrated. …”
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Performing whole-genome association analysis of winter wheat plant height using the 55K chip by Yindeng Ding, Guiqiang Fan, Yonghong Gao, Tianrong Huang, Anding Zhou, Shan Yu, Lianjia Zhao, Xiaolei Shi, Sunlei Ding, Jiahao Hao, Wei Wang, Jikun Song, Na Sun, Hui Fang

“…This study provides new genetic markers and resources for improving wheat plant height.…”
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