Novel Implications in Molecular Diagnosis of Lynch Syndrome by Raffaella Liccardo, Marina De Rosa, Paola Izzo, Francesca Duraturo

“…Moreover, it could also be possible that the simultaneous presence of these genetic variants in several MMR genes that behave as low risk alleles might contribute in a cooperative manner to increase the risk of hereditary cancer. …”
Get full text

Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ by Edward H. Leiter, Marjorie Strobel, Adam O'Neill, David Schultz, Andrew Schile, Peter C. Reifsnyder

“…Although the T2D pathophysiology in both TALLYHO/JngJ and NONcNZO10/LtJ is remarkably similar, their genetic etiologies are clearly different, underscoring the genetic heterogeneity underlying T2D in humans.…”
Get full text

A Case of Familial Mediterranean Fever with Extensive Lymphadenopathy and Complex Heterozygous Genotype Presenting in the Fourth Decade by Jawad Al-Khafaji, Fran Ganz-Lord, Venkata Rajesh Konjeti, Aaron D. Viny

“…Genetic investigation of the patient’s mother identified a novel carrier haplotype E148Q/P369S. …”
Get full text

Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…And yet, bizarrely, cells deploy this very machinery for the intentional and calculated disruption of genomic integrity, harnessing potentially destructive DSBs in delicate genetic transactions. Under tight spatiotemporal regulation, DSBs serve as a tool for genetic modification, widely used across cellular biology to generate diverse functionalities, ranging from the fundamental upkeep of DNA replication, transcription, and the chromatin landscape to the diversification of immunity and the germline. …”
Get full text

From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases by Winston Gilcrease, Luca Manfredi, Savino Sciascia, Fulvio Ricceri

“…In the context of rheumatic diseases, network medicine involves examining how different diseases interconnect and influence each other through shared pathways, genetic factors, and molecular mechanisms. This paradigm shift allows for a more holistic understanding in how we manage rheumatic diseases. …”
Get full text

High-throughput phenotyping techniques for forage: Status, bottleneck, and challenges by Tao Cheng, Dongyan Zhang, Gan Zhang, Tianyi Wang, Weibo Ren, Feng Yuan, Yaling Liu, Zhaoming Wang, Chunjiang Zhao

“…High-throughput phenotyping (HTP) technology is now a significant bottleneck in the efficient selection and breeding of superior forage genetic resources. To better understand the status of forage phenotyping research and identify key directions for development, this review summarizes advances in HTP technology for forage phenotypic analysis over the past ten years. …”
Get full text

Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications by Han Han, Erika M. Wolff, Gangning Liang

“…The characterization of the genetic alterations associated with UC has revealed the presence of two mutually exclusive molecular pathways along which distinct genetic abnormalities contribute to the formation of invasive and noninvasive tumors. …”
Get full text

Prediction of Surface Roughness in End Milling Process Using Intelligent Systems: A Comparative Study by Abdel Badie Sharkawy

“…They are (i) radial basis function neural networks (RBFNs), (ii) adaptive neurofuzzy inference systems (ANFISs), and (iii) genetically evolved fuzzy inference systems (G-FISs). …”
Get full text

Animal Models of Diabetes-Associated Renal Injury by Zahra Samadi Noshahr, Hossein Salmani, Abolfazl Khajavi Rad, Amirhossein Sahebkar

“…These models are developed by chemical, surgical, genetic, drug, and diet/nutrition interventions or combination of two or more methods. …”
Get full text

Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases by Ali Haydar Eskiocak, Birgul Ozkesici, Soner Uzun

“…Although there is some evidence pointing towards a genetic predisposition by some human leukocyte antigen (HLA) genes, familial occurrence of PV is very rare. …”
Get full text

The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases by César Pacheco-Tena, Susana Aideé González-Chávez

“…We assume that tissular dysfunction is a prerequisite for chronic autoimmunity and propose two genetically conferred hypothetical roles for the tissular cells causing the disease: (A) the Impaired cell and (B) the paranoid cell. …”
Get full text

Aflatoxin B1 impairs the growth and development of chicken PGCs through oxidative stress and mitochondrial dysfunction by Ying-Jie Niu, Jun Wu, Wenjie Ren, Guangzheng Liu, Gaoyuan Wu, Yixiu Peng, Dan Zheng, Kai Jin, Qisheng Zuo, Guohui Li, Wei Han, Xiang-Shun Cui, Guohong Chen, Bichun Li

“…Primordial germ cells (PGCs) in chickens, as ancestral cells of gametes, are essential for genetic transmission, yet the impact and mechanisms of aflatoxins on them remain elusive. …”
Get full text

Three new species of the spider genus Naphrys Edwards (Araneae, Salticidae) under morphology and molecular data with notes in the distribution of Naphrys acerba (Peckham & Peckham)... by Juan Maldonado-Carrizales, Alejandro Valdez-Mondragón, María L. Jiménez-Jiménez, Javier Ponce-Saavedra

“…The average interspecific genetic distance (p-distance) within the genus Naphrys is 14%, while the intraspecific genetic distances (p-distance) is <2% for most species. …”
Get full text

Morphophysiological approach to heterosis in phosphorus use efficiency in popcorn by Rosimeire Barboza Bispo, Antônio Teixeira do Amaral Junior, Talles de Oliveira Santos, Valter Jário de Lima, Bruna Rohem Simão, Marta Simone Mendonça Freitas, Samuel Henrique Kamphorst, Carolina Macedo Carvalho, Danielle Leal Lamêgo, Flávia Nicácio Viana, Wallace de Paula Bernardo, Eliemar Campostrini, Ricardo Bressan-Smith

“…Although heterosis is widely utilized in maize to enhance productivity, studies on the physiological mechanisms of heterosis expression in popcorn maize under P deficiency remain limited, as do investigations of genetic control during the juvenile phase. This study evaluated the genetic control and heterosis effects on growth traits, gas exchange, leaf pigments, chlorophyll fluorescence, and P efficiency in four popcorn maize inbred lines and their hybrids, including reciprocals. …”
Get full text

Genomic signatures of adaptation in native lizards exposed to human-introduced fire ants by Braulio A. Assis, Alexis P. Sullivan, Stephanie Marciniak, Christina M. Bergey, Vanessa Garcia, Zachary A. Szpiech, Tracy Langkilde, George H. Perry

“…Abstract Understanding the process of genetic adaptation in response to human-mediated ecological change will help elucidate the eco-evolutionary impacts of human activity. …”
Get full text

Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer by A. K. M. Firoj Mahmud, Dina Gamaleldin Mansour Aly, Yelin Zhao, Mikael Benson, Martin Smelik, Oleg Sysoev, Hui Wang, Xinxiu Li

“…This study investigates the genetic architecture of benign pancreatic cysts and its potential connection to PC using genome-wide association studies (GWAS). …”
Get full text

Linkage Mapping and Identification of Candidate Genes for Cold Tolerance in Rice (Oryza Sativa L.) at the Bud Bursting Stage by Lina Zhang, Fei Wang, Chunhui Liu, Xiaoding Ma, Di Cui, Bing Han, Longzhi Han

“…This study offers valuable genetic resources for further research on cold tolerance mechanisms and breeding applications at the bud bursting stage in rice.…”
Get full text

CORRELATION OF SINGLE NUCLEOTIDE POLYMORPHISM OF THE INTERLEUKIN-27 GENE IN AUTOIMMUNE THYROID DISEASE. by Maryam H. I, Abdulkareem A. Al-Kazaz

“…In conclusion, the study suggested that genetic polymorphism of IL-27 gene rs153109 may be associated with AITD risk among Iraqi population. …”
Get full text

Chromosome-scale genome assembly of Korean goosegrass (Eleusine indica) by Solji Lee, Changsoo Kim

“…The high-quality genome assembly of E. indica will serve as a valuable genetic resource to enhance our understanding of weed control research.…”
Get full text

Comprehensive transcriptomic analysis reveals turnip mosaic virus infection and its aphid vector Myzus persicae cause large changes in gene regulatory networks and co-transcription... by Venura Herath, Clare L. Casteel, Jeanmarie Verchot

“…Conclusions These combined data suggest that complex genetic changes occur as plants adapt to the combined challenges posed by aphids and the viruses they vector. …”
Get full text