Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring Citrobacter freundii in China with an IncR plasmid by Juanjuan Zhou, Minghui Zhen, Kaijie Gao, Lu Xu, Dongyu Zhang, Junmei Yang

“…The blaNDM-1 was integrated within the blaNDM-1 related region, which includes ΔISAba125, blaNDM-1, ble-MBL, trpF, dsbD, and ISCR1, while the blaKPC-2 gene was located on a novel non-Tn4401 genetic element. The blaKPC-2 genetic architectures containing blaKPC-2 differed from classical structures, underscoring the ongoing evolution of these genetic elements.IMPORTANCEOur study described the largest cohort to date of eight ST523 KPC-2-NDM-1-C. freundii isolated from children with urinary tract infections. …”
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Clinical follow-up of 2 families with glomerulopathy caused by COQ8B gene variants and literature review by Lei Zhang, Gentzon Hall, Peitong Han, Chunzhen Li, Jieyuan Cui

“…BackgroundPrimary coenzyme Q10 (CoQ10) deficiency is an autosomal recessive genetic disease caused by mitochondrial dysfunction. …”
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Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences by Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao

“…When this recombination phenomenon occurs in live vaccine strains, it becomes increasingly difficult to prevent and control PRRSV. Reverse genetic manipulation to engineer a different transcriptional regulatory sequence (TRS) circuit introduces genetic traps into the viral genome that are lethal to recombinant RNA progeny viruses. …”
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Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch... by Karl Michaëlsson, Rui Zheng, John A. Baron, Tove Fall, Alicja Wolk, Lars Lind, Jonas Höijer, Carl Brunius, Eva Warensjö Lemming, Olga E. Titova, Bodil Svennblad, Susanna C. Larsson, Shuai Yuan, Håkan Melhus, Liisa Byberg, Hannah L. Brooke

“…The genetically determined concentration of nine proteins influenced fat mass, and one influenced lean body mass. …”
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Monitoring of environmental gases and calf health in Italian Mediterranean buffalo herd by Simona Leonetti, Monica Ambrosio, Mirko Scamardella, Chiara Caso, Angelo Coletta

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Effects on Soil Aggregates and Organic Carbon Under a Triple-Cropping System in the Middle Reaches of the Yangtze River by Binjuan Yang, Qin Liu, Ning Liu, Yao Huang, Guoqin Huang

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Chromosome-level genome assembly of tetraploid Chinese cherry (Prunus pseudocerasus) by Wei Zhang, Jing Wang, Xuncheng Wang, Xuwei Duan, Junbo Peng, Xiaoming Zhang, Qikai Xing, Kaichun Zhang, Jiye Yan

“…The genome assembly presented here provides valuable genomic resources to enhance our understanding of genetic and molecular basis of Chinese cherry.…”
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Human Polymorphisms as Clinical Predictors in Leprosy by Ernesto Prado Montes de Oca

“…Genetic and serum markers in human host can predict leprosy susceptibility per se as well as be useful in classification and/or prediction of clinical variants and immunological responses in leprosy. …”
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Complications of Mesenteric Vein Thrombosis: Heterozygous Factor V Leiden Mutation Leads to Pulmonary Embolism in a Patient With Post–Bowel Resection Surgery by Hafiz Muhammad Hamza, Muhammad Muiz Malik, Ayaz Ahmed Awan, Muhammad Daoud Tariq, Mohamed Daoud, Aman Goyal

“…To effectively manage and prevent thrombotic episodes, prompt anticoagulant medication and genetic screening for family members are essential.…”
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Embracing plant plasticity or robustness as a means of ensuring food security by Saleh Alseekh, Annabella Klemmer, Jianbing Yan, Tingting Guo, Alisdair R. Fernie

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PECULIARITIES OF FIBER FLAX EVALUATION IN SOIL-MELIORATION CONDITIONS OF DRAINAGE by I. V. Ushchapovskii, L. N. Pavlova, E. M. Korneeva, N. B. Brutch

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SOURCES OF AGROBIOLOGICAL TRAITS FOR BREEDING SPRING BARLEY VARIETIES IN THE NORTH-WEST OF THE RUSSIAN FEDERATION by N. V. Ivanova, A. V. Anisimova, T. N. Radyukevich, O. N. Kovaleva

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THE FORMING OF PRODUCTIVITY IN SPRING BARLEY VARIETIES IN THE DRY STEPPE ZONE OF VOLGOGRAD PROVINCE by G. V. Kozubovskaya, O. Y. Kozubovskaya, V. I. Balakshina

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History and Status of Eucalyptus Improvement in Florida by Donald L. Rockwood

“…The collective accomplishments in terms of genetic resources and commercial planting are summarized. …”
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Comparative genomics of Aspergillus nidulans and section Nidulantes by Sebastian Theobald, Tammi Vesth, Jane L. Nybo, Jens C. Frisvad, Inge Kjærbølling, Stephen Mondo, Kurt LaButti, Sajeet Haridas, Robert Riley, Alan A. Kuo, Asaf A. Salamov, Jasmyn Pangilinan, Anna Lipzen, Maxim Koriabine, Mi Yan, Kerrie Barry, Alicia Clum, Ellen K. Lyhne, Elodie Drula, Ad Wiebenga, Astrid Müller, Ronnie J.M. Lubbers, Roland S. Kun, Ana Carolina dos Santos Gomes, Miia R. Mäkelä, Bernard Henrissat, Blake A. Simmons, Jon K. Magnuson, Jakob B. Hoof, Uffe H. Mortensen, Paul S. Dyer, Michelle Momany, Thomas O. Larsen, Igor V Grigoriev, Scott E. Baker, Ronald P. de Vries, Mikael R. Andersen

“…Comparative genomics reveals a high genetic diversity between species with 684 up to 2433 unique protein families. …”
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Total Anonychia Congenita with Carpal Synostosis by Milad Bahari, Negar Douzandeh

“…Background: Anonychia congenita is a rare genetic disorder of fingernails and/or toenails with unknown prevalence leading to aplasia of nail structures which may be seen either as an isolated abnormality or as part of a syndrome affecting multiple parts of the body such as nail-patella syndrome. …”
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Keratoconus with two consecutive re-emergences: a case report by Peicheng Zhang, Yanchao Wu, Lixiao Ma, Dong Wang

“…Conclusions Keratoconus is a complex disorder with a multifaceted etiology and pathogenesis, including genetic, environmental, biomechanical, and cellular factors. …”
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Erlotinib therapy for Olmsted syndrome with p.L655P missense mutation in the TRPV3 gene: a case report by Jia Zhang, MengYue Guo, DongYang Yuan, JinYang Wei, Hongzhou Cui, Hongzhou Cui

“…Here we describe a classically OS case with definitive diagnosis of OS based on clinical features and a genetic assay. Genetic analysis revealed heterozygous variants in the TRPV3 gene using whole-exome sequencing of case-parents’ trios. …”
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Exploring force-driven stochastic folding dynamics in mechano-responsive proteins and implications in phenotypic variation by Pritam Saha, Vishavdeep Vashisht, Ojas Singh, Amin Sagar, Gaurav Kumar Bhati, Surbhi Garg, Sabyasachi Rakshit

“…Abstract Single-point mutations are pivotal in molecular zoology, shaping functions and influencing genetic diversity and evolution. Here we study three such genetic variants of a mechano-responsive protein, cadherin-23, that uphold the structural integrity of the protein, but showcase distinct genotypes and phenotypes. …”
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HFE-Related Hemochromatosis: The Haptoglobin 2-2 Type Has a Significant but Limited Influence on Phenotypic Expression of the Predominant p.C282Y Homozygous Genotype by Gérald Le Gac, Chandran Ka, Isabelle Gourlaouen, Laurence Bryckaert, Anne-Yvonne Mercier, Brigitte Chanu, Virginie Scotet, Claude Férec

“…Phenotypic expression of the common p.C282Y/p.C282Y HFE-related hemochromatosis genotype is heterogeneous and depends on a complex interplay of genetic and non-genetic factors. Haptoglobin has a crucial role in free hemoglobin iron recovery, and exists as three major types: Hp1-1, Hp2-1 and Hp2-2. …”
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