Mitochondrial Neurogastrointestinal Encephalomyopathy: Novel Pathogenic Mutation in Thymidine Phosphorylase Gene in a Patient from Cape Verde Islands by Catarina Falcão de Campos, Miguel Oliveira Santos, Rafael Roque, Isabel Conceição, Mamede de Carvalho

“…The diagnostic workup was suggestive of MNGIE. Genetic screening of the TYMP gene identified a novel mutation (c. 1283 G>A). …”
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Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application by Romilly E. Hodges, Deanna M. Minich

“…Some caution is recommended, however, due to the limitations of current research as well as indications that many nutrients exert biphasic, dose-dependent effects and that genetic polymorphisms may alter outcomes. A whole-foods approach may, therefore, be prudent.…”
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E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer: A Proof-of-Concept Study by Saravanan Yuvaraj, Sa’ad H. Al-Lahham, Rajesh Somasundaram, Patrick A. Figaroa, Maikel P. Peppelenbosch, Nicolaas A. Bos

“…Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. …”
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Molecular landscape of lung cancer: insights into therapeutic targets and clinical outcomes by Saloni Mangal, Abhijit Debnath, Rupa Mazumder, Avijit Mazumder, Rajesh Kumar Singh, Jahanvi Sanchitra, S.K. Asif Jan, Pratibha Pandey, Bimlesh Kumar, Anil Kumar Singh

“…This review identifies and discusses key molecular and genetic targets for LC therapy, highlighting recent advancements and potential clinical applications. …”
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Scheduling strategy for science workflow with deadline constraint on multi-cloud by Bing LIN, Wenzhong GUO, Guolong CHEN

“…In view of the deadline-constrained scientific workflow scheduling on multi-cloud,an adaptive discrete particle swarm optimization with genetic algorithm (ADPSOGA) was proposed,which aimed to minimize the execution cost of workflow while meeting its deadline constrains.Firstly,the data transfer cost,the shutdown and boot time of virtual machines,and the bandwidth fluctuations among different cloud providers were considered by this method.Secondly,in order to avoid the premature convergence of traditional particle swarm optimization (PSO),the randomly two-point crossover operator and randomly one-point mutation operator of the genetic algorithm (GA) was introduced.It could effectively improve the diversity of the population in the process of evolution.Finally,a cost-driven strategy for the deadline-constrained workflow was designed.It both considered the data transfer cost and the computing cost.Experimental results show that the ADPSOGA has better performance in terms of deadline and cost reducing in the fluctuant environment.…”
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Thyroid Mutations and Implications for Clinical Treatment by Emily S. Zhang, Joseph Scharpf

“…Ultimately, the incorporation of genetic insights into clinical practice is essential for improving management strategies, minimizing overtreatment, and optimizing patient care in advanced thyroid cancer.…”
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Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease by Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin

“…Abstract Amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors. Numerous therapeutic approaches have been developed based on the genetic causes and potential mechanisms of ALS and HD. …”
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Jacobsen syndrome associated with Shone’s complex: a case report by Andressa Brum, Larissa Valéria Laskoski, Fabiana Gonçalves de Oliveira Azevedo Matos, Luciana Paula Grégio d’Arce

“…ABSTRACT Objective: The aim of this study was to report the case of a child with Jacobsen syndrome in order to provide phenotypic information about this rare genetic disorder. Case description: A 5-year-old female preschooler was diagnosed with Jacobsen syndrome by karyotype testing. …”
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Czy Europa zaakceptuje uprawy roślin genetycznie zmodyfikowanych? – argumenty i kontrargumenty by Jerzy Macewicz

“…This paper is a review of recent publications dealing with the consequences of the release of genetically modified (GM) crops into the environment. …”
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Enhancing Intelligent Control Strategies for UAVs: A Comparative Analysis of Fuzzy Logic, Fuzzy PID, and GA-Optimized Fuzzy PID Controllers by Nigatu Wanore Madebo

“…The GAFPID controller employs evolutionary computation through a genetic algorithm to optimize parameter tuning, offering superior control performance. …”
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Single-Cell Sequencing Technology in Oncology: Applications for Clinical Therapies and Research by Baixin Ye, Qingping Gao, Zhi Zeng, Creed M. Stary, Zhihong Jian, Xiaoxing Xiong, Lijuan Gu

“…Single-cell sequencing (SCS) technology has been recently employed for analyzing the genetic polymorphisms of individual cells at the genome-wide level. …”
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Updating Experimental Models of Diabetic Cardiomyopathy by J. Fuentes-Antrás, B. Picatoste, A. Gómez-Hernández, J. Egido, J. Tuñón, Ó. Lorenzo

“…Also, novel experimental models based on genetic modifications of specific related genes have been discussed. …”
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Network-assisted target identification for haploinsufficiency and homozygous profiling screens. by Sheng Wang, Jian Peng

“…Here, we present GIT (Genetic Interaction Network-Assisted Target Identification), a network analysis method for drug target identification in haploinsufficiency profiling (HIP) and homozygous profiling (HOP) screens. …”
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Psychocardiology, discipline is essential in these times by Teresa Rodríguez Rodríguez

“…The paper addresses the need to consider Psychocardiology indispensable in modern times, taking into account the continuous increase of cardiovascular disease, implying the existence of genetic markers, as well as psychological and social factors. …”
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Utility of multimodal imaging in the clinical diagnosis of inherited retinal degenerations by Brian J. H. Lee, Christopher Z. Y. Sun, Charles J. T. Ong, Kanika Jain, Tien-En Tan, Choi Mun Chan, Ranjana S. Mathur, Rachael W. C. Tang, Yasmin Bylstra, Sylvia P. R. Kam, Weng Khong Lim, Beau J. Fenner

“…Inherited retinal degeneration (IRD) is a heterogeneous group of genetic disorders of variable onset and severity, with vision loss being a common endpoint in most cases. …”
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Multi-block Analysis of Genomic Data Using Generalized Canonical Correlation Analysis by Inyoung Jun, Wooree Choi, Mira Park

“…Recently, there have been many studies in medicine related to genetic analysis. Many genetic studies have been performed to find genes associated with complex diseases. …”
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Therapeutic Implications of PPARγ in Human Osteosarcoma by Eric R. Wagner, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Wenli Zhang, Qiong Shi, Qing Luo, Xiaoji Luo, Bo Liu, Jinyong Luo, Farbod Rastegar, Connie J. He, Yawen Hu, Barrett Boody, Hue H. Luu, Tong-Chuan He, Zhong-Liang Deng, Rex C. Haydon

“…Although dysregulation of tumor suppressor genes and oncogenes, such as Rb, p53, and the genes critical to cell cycle control, genetic stability, and apoptosis have been identified in OS, consensus genetic changes that lead to OS development are poorly understood. …”
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An integrated methodological framework for the validation and verification of clinical testing by qRT-PCR by Carolina Cardona-Ramírez, Cruz Elena Enríquez-Valencia, Gina Méndez-Callejas, Giovanna Meza Barreto, Gabriel Andrés Tafur-Gómez, Danny Wilson Sanjuanelo-Corredor

“…Despite the prevalence of quantitative-qualitative screening in genetic testing, comprehensive validation guidelines remain a notable gap in the field. …”
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Toll-Like Receptor-Based Strategies for Cancer Immunotherapy by Saghar Pahlavanneshan, Ali Sayadmanesh, Hamidreza Ebrahimiyan, Mohsen Basiri

“…These strategies include systemic administration of TLR antagonist along with immune cell transfer and also genetic engineering of the immune cells using TLR signaling components to improve the function of genetically engineered immune cells such as chimeric antigen receptor-modified T cells. …”
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Varied Age of First Presentation of Sickle Cell Disease: Case Presentations and Review by Alexis Claeys, Susanne Van Steijn, Lydia Van Kesteren, Elizabet Damen, Machiel Van Den Akker

“…The individual course of sickle cell disease depends on (epi) genetic and environmental properties and the underlying interactions. …”
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