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7181
Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease
Published 2025-01-01“…While early-onset AD has well-established genetic determinants, the genetic basis for late-onset AD remains less clear. …”
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7182
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7183
Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations
Published 2024-12-01“…Methods Four carriers of a primary CME and three non-methylated relatives carrying the same genetic haplotype were included. Genetic alterations were sought using linked-read WGS in blood DNA. …”
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7184
Enhancement of systemic and lung-localized CD4<sup>+</sup> T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain
Published 2024-11-01“…Materials and methods. Using reverse genetics technique, two H1N1 LAIV strains with full-length and truncated NS1 protein with three consecutive stop codons added after the 126th amino acid residue were obtained.C57BL/6J mice were immunized intranasally with the vaccine candidates, twice at a three-week interval. …”
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7185
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7186
From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments
Published 2025-01-01“…Thus, more and more studies are trying to ascertain the potential transformation mechanisms through multi-omics, including genetics, transcriptomics, and epigenetics. In this review, we gave an overview of the specific biomarkers and signaling pathways that may be involved in the pathogenesis from AK to cSCC, pointing out future possible molecular therapies for the early intervention of AK and cSCC. …”
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7187
Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions
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7188
Combined biochemical profiling and DNA sequencing in the expanded newborn screening for inherited metabolic diseases: the experience in an Italian reference center
Published 2025-01-01“…Advanced molecular technologies point to genomic sequencing as an alternative and feasible strategy for the screening of genetic diseases, including IMDs. However, each of the two approaches has potential limitations when used as a first-tier analysis. …”
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7189
THE АNAPA AMPELOGRAPHIC COLLECTION IS THE LARGEST CENTER OF VINE GENE POOL ACCUMULATION AND RESEARCH IN RUSSIA
Published 2018-03-01“…We carry out a molecular genetic testing of the accumulated gene pool and DNA-classification of varieties. …”
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7190
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7191
Antifungal activity and mechanism of Phoebe bournei wood essential oil against two dermatophytes
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7192
Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemothera...
Published 2025-02-01“…To identify patient subgroups that might benefit from multimodal surgical therapy, additional information on tumor genetics could supplement valid parameters. Trial registration EU Clinical Trials No. 2023-503558-10-00.…”
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7193
Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study
Published 2025-01-01“…., demographics, pre-existing conditions and/or genetics), thus complicating the prediction of clinical outcomes for different severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants. …”
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7194
Infection‐Related Hospitalization and Incident Heart Failure: The Atherosclerosis Risk in Communities Study
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7196
The Role of circTmeff-1 in Morphine Addiction Memory of Mice
Published 2023-08-01“…CircRNAs, an emerging hotspot regulator in crown genetics, play an important role in central nervous system-related diseases. …”
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Principles of Medical Biochemistry /
Published 2017Table of Contents: “…Introduction to biomolecules -- Introduction to protein structure -- Oxygen-binding proteins : hemoglobin and myoglobin -- Enzymatic reactions -- Coenzymes -- DNA, RNA, and protein synthesis -- The human genome -- Protein targeting and proteostasis -- Introduction to genetic diseases -- Viruses -- DNA technology -- Biological membranes -- The cytoskeleton -- The extracellular matrix -- Extracellular messengers -- Intracellular messengers -- Plasma proteins -- Defense mechanisms -- Cellular growth control and cancer -- Digestive enzymes -- Introduction to metabolic pathways -- Glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation -- Oxygen deficiency and oxygen toxicity -- Carbohydrate metabolism -- The metabolism of fatty acids and triglycerides -- The metabolism of membrane lipids -- Lipid transport -- Amino acid metabolism -- Metabolism of iron and heme -- The metabolism of purines and pyrimidines -- Micronutrients -- Integration of metabolism.…”
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7199
The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years
Published 2025-12-01“…Traumatic events may have a wide range of transdiagnostic mental and physical health consequences, not limited to posttraumatic stress disorder (PTSD). Research on genetic, molecular, and neurobiological influences show promise for further understanding underlying risk and resilience for trauma-related consequences. …”
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7200