Case report: Personalized management of treatment resistance in advanced NSCLC patients with mutated epidermal growth factor receptor: special examples and literature review by Jun Wang, Jun Wang, Xiaojing Li, Shuang Dong, Sheng Hu, Fengming Ran, Yu Qian

“…The treatment landscape of non-small cell lung cancer (NSCLC) has shifted significantly from empirical, histology-driven, and clinician-directed cytotoxic regimens to a stratified approach predicated on molecular profiling of tumor genetics and immune biomarkers, by the former can indicate targeted therapy that bull’s eye hits the arrow, while the latter can hint the benefit amplitude of immune checkpoint inhibitors (ICBs). …”
Get full text

Composition of Anthocyanins in Colored Grains and the Relationship of Their Non-Acylated and Acylated Derivatives by Sladjana Zilic, Dejan Dodig, Jelena Vancetovic, Nikola Grcic, Vesna Peric, Primoz Titan, Vuk Maksimovic

Get full text

Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study by Mahshid Taherkhani, Farzaneh Montazerifar, Azita Hekmatdoost, Bahram Rashidkhani, Abolfazl Payandeh, Mansour Karajibani

Get full text

Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls by Marco Peluso, Armelle Munnia, Sara Piro, Alessandra Armillis, Marcello Ceppi, Giuseppe Matullo, Riccardo Puntoni

Get full text

Kazakhstan-Siberian spring common wheat identification according to glutenin and gliadin composition by A. I. Abugalieva, A. I. Morgunov, J. R. Pena, N. B. Volkovinskaya, T. V. Savin

Get full text

Causal association among smoking, bitter beverage consumption, and risk of osteoporosis: a two-sample mendelian randomization-based study by Yanqian Wu, Jianqian Chao, Min Bao, Na Zhang, Leixia Wang

“…No genetic causal association was found between smoking initiation or lifetime smoking index and the risk of osteoporosis (P > 0.05). …”
Get full text

Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation by Guanying Yao, Xianchao Dou, Xiaozhu Chen, Haolin Qi, Jianling Chen, Peiwei Wu, Jialu Li, Shuang Liang, Zhongjiang Han, Shun Bai, Xu Hu

Get full text

Biological factors controlling starch digestibility in human digestive system by Cheng Li, Yiming Hu, Songnan Li, Xueer Yi, Shuaibo Shao, Wenwen Yu, Enpeng Li

Get full text

Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner by Bojana Simovic Markovic, Marina Gazdic, Aleksandar Arsenijevic, Nemanja Jovicic, Jovana Jeremic, Valentin Djonov, Nebojsa Arsenijevic, Miodrag L. Lukic, Vladislav Volarevic

Get full text

Dependence of the content of starch and reducing sugars on the level of expression of the genes of β-amylases StBAM1 and StBAM9 and the amylase inhibitor StAI during long-term low-... by A. V. Kulakova, G. I. Efremov, A. V. Shchennikova, E. Z. Kochieva

Get full text

Changes in Polyphenols Contents and Antioxidant Capacities of Organically and Conventionally Cultivated Tomato (Solanum lycopersicum L.) Fruits during Ripening by Dea Anton, Ingrid Bender, Tanel Kaart, Mati Roasto, Marina Heinonen, Anne Luik, Tõnu Püssa

Get full text

Influence of the biologically active dietary supplement Floravit® on the skin and hair structure in sable (Martes zibellina) by N. N. Loenko, I. E. Chernova, T. S. Kunitsina

Get full text

Species delimitation and microalgal cryptic diversity analysis of the genus Micractinium (Chlorophyta) by E. S. Krivina, A. D. Temraleeva, Yu. S. Bukin

“…The clustering obtained by the latter two methods is in good congruence with morphological (cell size and shape, ability to form colonies, production of bristles, chloroplast type), physiological (vitamin requirements, reaction to high and low temperatures), molecular (presence of introns, level of genetic differences, presence of CBCs or special features of the secondary structure in ITS1 and ITS2) and ecological characteristics (habitat). …”
Get full text

SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla by Alice Santambrogio, Yasmine Kemkem, Thea L. Willis, Ilona Berger, Maria Eleni Kastriti, Louis Faure, John P. Russell, Emily J. Lodge, Val Yianni, Bence Kövér, Rebecca J. Oakey, Barbara Altieri, Stefan R. Bornstein, Charlotte Steenblock, Igor Adameyko, Cynthia L. Andoniadou

“…In this work, we demonstrate that a subset of sustentacular cells endowed with a support role, are in fact adrenomedullary stem cells. Through genetic tracing and comprehensive transcriptomic data of the mouse adrenal medulla, we show that cells expressing Sox2/SOX2 specialise as a unique postnatal population from embryonic Schwann Cell Precursors and are also present in the normal adult human adrenal medulla. …”
Get full text

Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults by Mehdi Mollahosseini, Zeinab Yazdanpanah, Azadeh Nadjarzadeh, Masoud Mirzaei, Seyed Mehdi Kalantar, Hamid Reza Ashrafzadeh, Khadijeh Mirzaei, Hassan Mozaffari-Khosravi

Get full text

Research note: Increased lipid accumulation within broiler preadipocytes during differentiation in vitro at atmospheric oxygen tension by Jéssica Moraes Cruvinel, Elizabeth S. Greene, Rachel W. Read, Kichoon Lee, Sami Dridi, Paula R. Chen

“…In the broiler industry, intensive genetic selection has been placed on muscle growth which has undesirably led to increased fat accretion. …”
Get full text

Gibberellin Treatment Toward Off-crop Season as a Practical Tool to Increase Yield in ‘Orri’ Mandarin by Dor Haim, Itzhak Kamara, Michael Morozov, Avi Sadka

Get full text

Placenta-derived mesenchymal stem cells protect against diabetic kidney disease by upregulating autophagy-mediated SIRT1/FOXO1 pathway by Honghong Liu, Jiao Wang, Guanru Yue, Jixiong Xu

Get full text

mRNA technology as one of the promising platforms for the SARS-CoV-2 vaccine development by A. A. Ilyichev, L. A. Orlova, S. V. Sharabrin, L. I. Karpenko

Get full text

Modelling relative richness of flooding-response groups to predict hydrology-driven change in wetland plant communities by David C. Deane, Michelle T. Casanova, Jason Nicol, Justin D. Brookes

Get full text