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5081
Considerations in the search for epistasis
Published 2024-11-01“…Abstract Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. …”
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5082
Problems with studying directional natural selection in humans
Published 2023-11-01“…These include bioinformatic analysis of DNA sequences via detection of linkage disequilibrium and of deviations from the random distribution of frequencies of genetic variants, demographic and anthropometric studies based on a search for a correlation between fertility and phenotypic traits, genome-wide association studies on fertility along with genetic loci and polygenic risk scores, and a comparison of allele frequencies between generations (in modern samples and in those obtained from burials). …”
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5088
Orthologous marker groups reveal broad cell identity conservation across plant single-cell transcriptomes
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5090
Use of a Sendai virus-based vector for effcient transduction of pinniped fbroblasts
Published 2019-01-01“…We performed delivery of genetic constructions carrying fluorescent proteins to fbroblasts of seven Pinnipeds: northern fur seal (Callorhinus ursinus), Steller sea lion (Eumetopias jubatus), walrus (Odobenus rosmarus), bearded seal (Erignathus barbatus), Baikal seal (Pusa sibirica), ringed seal (Phoca hispida), and spotted seal (Phoca largha). …”
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5091
Automated Zebrafish Spine Scoring System Based on Instance Segmentation
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5092
The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation
Published 2023-04-01“…In doing so, our model captures the effects of genetic drift, linked selection and local mutation rates on patterns of genomic variation. …”
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5093
Neurophysiological Endophenotypes, CNS Disinhibition, and Risk for Alcohol Dependence and Related Disorders
Published 2007-01-01“…These findings underscore the utility of quantitative neurophysiological endophenotypes in the study of the genetics of complex disorders. We will present our recent genetic findings related to brain oscillations and Central Nervous System (CNS) disinhibition.…”
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Etiopathogenesis of Sheehan’s Syndrome: Roles of Coagulation Factors and TNF-Alpha
Published 2014-01-01“…Hence, we suggest that genetic factors other than Factor II, Factor V, MTHFR, PAI-1, and TNF-α gene polymorphisms should be researched in the etiopathogenesis of SS.…”
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5097
Frontotemporal Dementia, Manifested as Schizophrenia, with Decreased Heterochromatin on Chromosome 1
Published 2012-01-01“…Frontotemporal dementia is a disorder of complex etiology, with genetic components contributing to the disease. The aim of this report is to describe a young patient suffering from frontotemporal dementia, misdiagnosed as schizophrenia, related to a genetic defect on chromosome 1. …”
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5098
CRALBP is a Highly Prevalent Autoantigen for Human Autoimmune Uveitis
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5099
Optogenetic regulation of endogenous gene transcription in mammals
Published 2019-03-01“…In addition, such systems are of particular interest for genetics, molecular and cell biology. An ideal system should ensure tunable and reversible spatio-temporal control over transcriptional activity of a gene of interest. …”
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5100
Characterisation of Drosophila UbxCPTI000601 and hthCPTI000378 Protein Trap Lines
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