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    Bimodal Patterns of Locomotor Activity and Sleep in Drosophila: A Model for Their Simulation by Putilov AA, Verevkin EG, Petrovskii DV, Zakharenko LP

    Published 2025-01-01
    “…Arcady A Putilov,1,* Evgeniy G Verevkin,1,* Dmitrii V Petrovskii,2,* Lyudmila P Zakharenko2,* 1Independent Research Group “biomedical Systems Math-Modeling”, Berlin, 12489, Germany; 2Department of Insect Genetics, Institute of Cytology and Genetics of the Siberian Branch, the Russian Academy of Sciences, Novosibirsk, 630090, Russia*These authors contributed equally to this workCorrespondence: Arcady A Putilov, Independent Research Group “Biomedical Systems Math-Modeling, 11, Nipkowstr, Berlin, 12489, Germany, Tel/Fax +0049-30-53674643, Email arcady.putilov@gmail.comPurpose: Two previously proposed modelling approaches to explain the bimodal pattern of activity and/or sleep in Drosophila melanogaster are based on 1) the concept of morning and evening oscillators underlying the peaks of activity in the morning and evening, respectively, and 2) the concept of two cycles of buildup and decay of sleep pressure, gated only by the circadian oscillator. …”
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    p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment by Darya Yanushko, Beatriz German Falcon, Rana El Bizri, Despoina Pervizou, Robin Dolgos, Céline Keime, Tao Ye, Christelle Thibault-Carpentier, Clementine Le Magnen, Sandrine Henri, Gilles Laverny, Daniel Metzger

    Published 2025-01-01
    “…The progression of solid tumors to metastasis is often associated with increased cell plasticity, but the complex events underlying TP53-loss-induced disease aggressiveness remain incompletely understood. Using genetically engineered mice, we show that Trp53 deficiency in Pten-null prostatic epithelial cells (PECs) does not impact early cell proliferation and neoplasia formation, nor growth arrest and senescence entry at a later time. …”
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    Evaluation of synthetic wheat lines (Triticum durum/Aegilops tausсhii) for vegetative period and resistance to diseases by V. P. Shamanin, I. V. Pototskaya, S. S. Shepelev, V. E. Pozherukova, A. Yu. Truschenko, A. S. Chursin, A. I. Morgunov

    Published 2017-05-01
    “…Increase of resistance to stress factors in the emerging varieties can be achieved by utilizing the diversity of the genetic resources of related wild species and genera in crosses. …”
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