The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia by Ekati Drakopoulou, Eleni Papanikolaou, Nicholas P. Anagnou

“…Furthermore, as human HSCs have intrinsic barriers to HIV-1 infection, attention is drawn towards their ex vivo manipulation, aiming to achieve higher yield of genetically modified HSCs. This paper presents the current status of gene therapy for β-thalassemia, its success and limitations, and the novel promising strategies available involving the therapeutic role of HSCs.…”
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Trait and plasticity evolution under competition and mutualism in evolving pairwise yeast communities. by ShengPei Wang, Renuka Agarwal, Kari A Segraves, David M Althoff

“…We experimentally tested how competition and mutualism affected trait and plasticity evolution of pairwise communities of genetically modified brewer's yeast. We quantified evolutionary changes in growth rate, resource use efficiency (RUE), and their plasticity in strains evolving alone, with a competitor, and with a mutualist. …”
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Densely vascularized thick 3D tissue shows enhanced protein secretion constructed with intermittent positive pressure by Misako Katsuura, Jun Homma, Yuhei Higashi, Hidekazu Sekine, Tatsuya Shimizu

“…Furthermore, in vivo experiments showed that IPP-cultured cell sheets enhanced the secretion of Gaussian luciferase by genetically modified mesenchymal stem cells. These findings highlight the IPP method as a technique that simultaneously enables the thickening of planar tissues and the construction of vascular networks. …”
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Diversity and bioindicators of natural enemies in organic paddy fields implementing habitat modification by Setyadin Yuris, Leksono Amin Setyo, Tarno Hagus

“…Organic systems are a viable alternative characterized by organic fertilizers and biopesticides, avoiding genetically modified microorganisms and promoting biodiversity. …”
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Europejska Konwencja Bioetyczna w ochronie (bio)bezpieczeństwa człowieka w obszarze biomedycyny: wymiar jednostkowy i społeczny by Mariusz Ciszek

“…It was noticed that biosafety was related to three basic dimensions of threats to human safety connected with biotechnological products. They are genetically modified organisms (GMO), the use of biological weapons, and the development of biomedical disciplines. …”
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Addressing the limitations of the regulatory landscape in South Africa regarding advanced cell and gene therapies and related sectors involving human cells, tissues and organs by I M Viljoen, M S Pepper

“…However, South Africa (SA)’s regulatory frameworks for medicines, human biological materials and genetically modified organisms have not kept pace with scientific and technological developments, leaving regulatory gaps. …”
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Selective Herbicides for Cultivation of Eucalyptus urograndis Clones by Patrick J. Minogue, Anna Osiecka

“…Five herbicides, flumioxazin, imazamox, imazapic, oxyfluorfen, and sulfometuron methyl, were evaluated for selective weed control in the establishment of genetically modified frost tolerant Eucalyptus urograndis clones. …”
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The role of oxidative stress, glucocorticoid receptor and ARMC5 in lipid metabolism by Yosuke Okuno, Atsunori Fukuhara, Iichiro Shimomura

“…We previously found novel roles of adipocyte oxidative stress in diet-induced obesity, adipocyte glucocorticoid receptor in Cushing syndrome, and ARMC5 in adrenocortical cells. Using genetically modified mice in which oxidative stress was eliminated or augmented specifically in adipose tissues, we have been able to elucidate that obesity-induced oxidative stress inhibited healthy adipose expansion and ameliorated insulin sensitivity. …”
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A Cell Model for Conditional Profiling of Androgen-Receptor-Interacting Proteins by K. A. Mooslehner, J. D. Davies, I. A. Hughes

“…For this purpose, male genital development relevant mouse cell lines were genetically modified to express a tagged version of wild-type AR, allowing copurification of multiprotein complexes under native conditions followed by mass spectrometry. …”
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The Role of NK Cells in Pig-to-Human Xenotransplantation by Gisella Puga Yung, Mårten K. J. Schneider, Jörg D. Seebach

“…The potential of cell-based strategies including tolerogenic dendritic cells (DC) and regulatory T cells (Treg) and the latest progress using transgenic pigs genetically modified to reduce xenogeneic NK cell responses are discussed. …”
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Analysis of Fractional Order Mathematical Model of Hematopoietic Stem Cell Gene-Based Therapy by Mohammad Imam Utoyo, Windarto, Aminatus Sa’adah

“…This therapy protects target cells from infections or specifying technic and immune responses to face virus by using genetically modified HSCs. A mathematical model approach could be used to predict the dynamics of HSC gene-based therapy of viral infections. …”
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Microscopic Analysis of Severe Structural Rearrangements of the Plant Endoplasmic Reticulum and Golgi Caused by Overexpression of Poa semilatent virus Movement Protein by Andrey G. Solovyev, Joachim Schiemann, Sergey Y. Morozov

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Comparative Study of Various E. coli Strains for Biohydrogen Production Applying Response Surface Methodology by Péter Bakonyi, Nándor Nemestóthy, Katalin Bélafi-Bakó

“…In present paper, it was aimed to show the utility both of strain engineering and process optimization through a comparative study of wild-type and genetically modified E. coli strains, where the effect of two major operational factors (substrate concentration and pH) on bioH2 production was investigated by experimental design and response surface methodology (RSM) was used to determine the suitable conditions in order to obtain maximum yields. …”
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The Pricing Strategy of Oligopolistic Competition Food Firms with the Asymmetric Information and Scientific Uncertainty by Li Zhao, Changwei Wang, Xiaohui Peng, Bin Liu, David Ahlstrom

“…The arguments for and against genetically modified (GM) food focus on the characteristics of the scientific uncertainty and asymmetric information for the GM food. …”
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Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective by Deqin Hu, Dongmei Wang, Hongsheng Pan, Xiaoning Liu

“…Genetically modified crops that produce insecticidal proteins from <i>Bacillus thuringiensis</i> (<i>Bt</i>) are currently the most efficient and safest method of pest control worldwide. …”
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Long-term consequences of the Chornobyl disaster for aquatic ecosystems: A retrospective analysis and prognosis by R. Makhinko

“…A set of innovative measures to minimise negative consequences was proposed, including the use of nanotechnologies, genetically modified organisms, and automated monitoring systems. …”
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A comprehensive review of biological and genetic control approaches for leishmaniasis vector sand flies; emphasis towards promoting tools for integrated vector management. by Yasoda Kumari, Nayana Gunathilaka, Deepika Amarasinghe

“…This current review identified several promising methods, including genetically modified sand flies, using transgenic approaches by taking advanced gene editing tools like Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) and genetic modification of symbiotic microorganisms for controlling sand fly populations, which appeared to be proven under laboratory and field settings.…”
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Present-day breeding of legumes and groat crops in Russia by V. I. Zotikov, S. D. Vilyunov

“…It is important that our soybean varieties are not genetically modified. New pea varieties created at FSC LGC in 2015–2020 differ in growing season duration and morphological features. …”
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Lyophilized B. subtilis ZB183 Spores: 90-Day Repeat Dose Oral (Gavage) Toxicity Study in Wistar Rats by B. Appala Naidu, Kamala Kannan, D. P. Santhosh Kumar, John W. K. Oliver, Zachary D. Abbott

“…A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on lyophilized spores of the novel genetically modified strain B. subtilis ZB183. Lyophilized spores at doses of 109, 1010, and 1011 CFU/kg body weight/day were administered by oral gavage to Wistar rats for a period of 90 consecutive days. …”
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The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model by Jagoda Mierzejewska, Katarzyna Węgierek-Ciura, Joanna Rossowska, Agnieszka Szczygieł, Natalia Anger-Góra, Bożena Szermer-Olearnik, Magdalena Geneja, Elżbieta Pajtasz-Piasecka

“…On the 15th day, DCs genetically modified for production of IL-12 and/or IL-18 were administered peritumorally to C57BL/6 female mice with established MC38 tumors. …”
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