STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease by Ying Tang, Sanda A. Tan, Atif Iqbal, Jian Li, Sarah C. Glover

“…Crohn’s disease (CD) results from dysregulated immune responses to gut microbiota in genetically susceptible individuals, affecting multiple areas of the gastrointestinal tract. …”
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Adverse Immunologically Mediated Oral Mucosal Reactions to Systemic Medication: Lichenoid Tissue Reaction/Interface Dermatitis-Stomatitis, Autoimmune Vesiculobullous Disease, and I... by R. A. G. Khammissa, R. Chandran, A. Masilana, J. Lemmer, L. Feller

“…Drug-induced hypersensitivity immune reactions are exaggerated immunoinflammatory responses to allergenic components of the medications that occur in genetically susceptible subjects. The type of hypersensitivity immune response generated, whether antibody mediated or T cell mediated, or an immune complex reaction is determined by multiple factors, including the molecular characteristics of the allergen, the route of administration of the medication, the manner of presentation of the allergen by antigen-presenting cells to naïve T cells, the repertoire of the T cell receptors, and the cytokine profile within the microenvironment. …”
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Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis by Milan Buc

“…It is caused by an autoimmune response to self-antigens in a genetically susceptible individual induced by unknown environmental factors. …”
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Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases by Donatella Comito, Claudio Romano

“…Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract that occur in genetically susceptible individuals. Crohn’s disease (CD) and ulcerative colitis (UC) are two major types of IBD. …”
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Kawasaki Disease: A Clinician’s Update by Nathan Jamieson, Davinder Singh-Grewal

“…The disease is believed to result from a genetically susceptible individual’s exposure to an environmental trigger. …”
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Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats by Artur Dembiński, Zygmunt Warzecha, Piotr Ceranowicz, Marcin Dembiński, Jakub Cieszkowski, Tomasz Gosiewski, Małgorzata Bulanda, Beata Kuśnierz-Cabala, Krystyna Gałązka, Peter Christopher Konturek

“…Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of acetic acid-induced colitis. …”
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Clinical Onset of Celiac Disease after an Episode of Campylobacter jejuni Enteritis by EF Verdu, M Mauro, J Bourgeois, D Armstrong

“…The present case suggests that the clinical expression of CD can be unmasked by an acute gastrointestinal infection and supports the hypothesis that environmental factors other than gliadin may play a role in the clinical onset of CD in a genetically susceptible host. The increasing availability of serological testing and upper endoscopy has led to increasingly frequent diagnoses of CD and recognition that it may mimic IBS. …”
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Manifestaciones bucales de la enfermedad celíaca en pacientes geriátricos consumidores de gluten by Gladys Aída Estrada Pereira, Jesús Díaz Fondén, Alina Márquez Chacón

“…<p><strong>Foundation</strong>: Celiac disease is a chronic inflammatory and autoimmune disease that affects genetically susceptible individuals due to a permanent intolerance to gluten. …”
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Development and validation of a risk assessment tool for uncontrolled type 2 diabetes among patients in South Karnataka, India by Deepak Anil, Sunil Kumar Doddaiah, Rajendra Prasad Shivaswamy, Arun Gopi, Sayana Basheer, Mysore Ramakrishnaiah Narayana Murthy

“…Introduction Diabetes is a chronic medical condition with severe complications mainly caused due to unhealthy lifestyles in genetically susceptible individuals. This study attempts to develop a non-invasive risk assessment tool to identify patients with uncontrolled type 2 diabetes mellitus (T2DM) in southern India.Methodology An exploratory study was conducted among 545 patients with T2DM in the Mysuru district, South India for 6 months. …”
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Atherosclerotic Risk Factors in Children with Celiac Disease by Anna Rybak, Aldona Wierzbicka, Piotr Socha, Anna Stolarczyk, Bożena Cukrowska, Łukasz Obrycki, Zbigniew Wawer, Roman Janas, Beata Oralewska, Anna Szaflarska-Popławska, Barbara Iwańczak, Elżbieta Cyrta-Jarocka, Urszula Grzybowska-Chlebowczyk, Wojciech Cichy, Grażyna Czaja-Bulsa, Jerzy Socha

“…Celiac disease (CD) is a complex autoimmune disorder occurring in genetically susceptible individuals. There is limited data on the impact of gluten-free diet (GFD) on the risk of developing cardiovascular diseases. …”
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A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…Finally, these findings underscore the importance of considering environmental factors in the development and course of PV in genetically susceptible individuals.…”
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