Advances in Murine Models of Diabetic Nephropathy by Li-li Kong, Hao Wu, Wen-peng Cui, Wen-hua Zhou, Ping Luo, Jing Sun, Hang Yuan, Li-ning Miao

“…Here we review the identified murine models of DN from the aspects of genetic background, type of diabetes, method of induction, gene deficiency, animal age and gender, kidney histopathology, and phenotypic alterations in the hope of enhancing our comprehension of genetic susceptibility and molecular mechanisms responsible for this disease and providing new clues as to how to choose appropriate animal models of DN.…”
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Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? by Grazyna Deja, Przemyslawa Jarosz-Chobot, Joanna Polanska, Urszula Siekiera, Ewa Malecka-Tendera

“…The aim of the study was to assess chosen factors of genetic susceptibility to DMT1: DRB1, DQB1, and TNF-α polymorphisms-308 (G/A) in children with DMT1 and their up-to-now healthy siblings. …”
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Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers by Matthaios Speletas, Vassiliki Merentiti, Konstantinos Kostikas, Kyriaki Liadaki, Markos Minas, Konstantinos Gourgoulianis, Anastasios E. Germenis

“…However, not all smokers develop COPD and other environmental and genetic susceptibility factors underlie disease pathogenesis. …”
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Association of COMT Val158Met Polymorphism with Fibromyalgia in Khartoum State, Sudan by Safaa Mamoun Abdelmageid, Faisal Mousa Alamir, Hassan Yousif Abdelrahman, Hind Mohamed Abushama

“…This is the first study in Sudan addressing FM cases and genetic susceptibility to the disease. We aimed in this study to investigate the frequency of COMT Val 158 Met polymorphism among patients with FM, rheumatoid arthritis, and in healthy individuals. …”
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The Impact of Selected Regimens of Chronic HIV‐Antiretroviral Treatment on Glycemic Control Markers and Correlates: A Systematic Review and Meta‐Analysis Protocol by Mlindeli Gamede, Mbulelo Aubrey Sosibo, Nontobeko Gumede, Mluleki Luvuno

“…The etiology of diabetes can be mainly attributed to factors such as genetic susceptibility, unhealthy diets, and chronic medications. …”
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Fluoride-induced testicular and ovarian toxicity: evidence from animal studies by Seyedeh Fahimeh Talebi, Mohammad Seify, Ramji Kumar Bhandari, Hamed Shoorei, Shahram Dabiri Oskuei

“…Furthermore, genetic susceptibility and individual variations in F metabolism may contribute to different responses to fluoride exposure.…”
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Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India by Ranjan S. Rana, Bitan Naik, Mahima Yadav, Usha Singh, Anup Singh, Shailja Singh

“…The most appropriate hypothesis states that genetic susceptibility in the presence of environmental risk factors predisposes to SLE. …”
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Recent Advances in Vaginal Atresia: A Literature Review by Xijuan Lin, Jia Kang, Lan Zhu

“…In this context, this article systematically reviews the epidemiological characteristics of vaginal atresia and explores its etiology from multiple perspectives, including developmental processes, genetic factors, and environmental factors, emphasizing the importance of genetic susceptibility and environmental interactions in the pathogenesis of the condition. …”
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Caveolin Gene, a Possible Risk Factor for Metabolic Syndrome in Humans: A Systematic Review and Meta-Analysis by Mohadeseh Arefian, Sadegh Mazaheri-Tehrani, Maryam Yazdi, Roya Kelishadi

“…With future studies focusing on the matter, this gene can be used as a screening tool for metabolic health to detect individuals with a higher genetic susceptibility to metabolic syndrome.…”
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A Review on Automatic Mammographic Density and Parenchymal Segmentation by Wenda He, Arne Juette, Erika R. E. Denton, Arnau Oliver, Robert Martí, Reyer Zwiggelaar

“…There are more than 70 common genetic susceptibility factors included in the current non-image-based risk prediction models (e.g., the Gail and the Tyrer-Cuzick models). …”
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Sex Differences in the Allele Distribution of PGLYRP2 Variant rs892145 in Parkinson’s Disease by Caroline Ran, Karin Wirdefeldt, Olof Sydow, Per Svenningsson, Rochellys Diaz Heijtz

“…Parkinson’s disease (PD) is a complex multifactorial disease, involving genetic susceptibility, environmental risk factors, and gene-environmental interactions. …”
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Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer by Jae Sook Sung, Kyong Hwa Park, Seung Tae Kim, Yeul Hong Kim

“…These results suggest that polymorphisms of the AKT2 and AKT3 promoter regions do not contribute to the genetic susceptibility to lung cancer in the Korean population.…”
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Clinical Characteristics in Patients with Triple Negative Breast Cancer by Janet Yeh, Jennifer Chun, Shira Schwartz, Annie Wang, Elizabeth Kern, Amber A. Guth, Deborah Axelrod, Richard Shapiro, Freya Schnabel

“…The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. …”
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Prevalence and risk factors of the most common multimorbidity among Canadian adults. by Obed Mortey, Gerald Mugford, Kris Aubrey-Bassler, Hensley H Mariathas, Ugochukwu Odimba, Zhiwei Gao

“…Traditionally, this increase has been attributed to a growing aging population, sedentary lifestyle, obesity, low socioeconomic status, and individual genetic susceptibility.<h4>Objective</h4>To investigate the prevalence and associated risk factors of the most common multimorbidity (MCM) among Canadian middle-aged and older adults.…”
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Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand by Taweesak Tongtawee, Soraya Kaewpitoon, Natthawut Kaewpitoon, Chavaboon Dechsukhum, Wilairat Leeanansaksiri, Ryan A. Loyd, Likit Matrakool, Sukij Panpimanmas

“…Risk factors for Helicobacter pylori infection are genetic susceptibility and poor living conditions. This study aimed to investigate the Mdm2 gene, clarithromycin resistance, and possible risk factors for Helicobacter pylori infection. …”
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Lipidomics-based investigation of its impact on the pathogenesis of coronary atherosclerosis: a Mendelian randomization study by Qun Wang, Yuan Cao, Lianqun Jia

“…Two GWAS datasets were examined to take intersections of SNPs from 51,589 cases and 343,079 controls, and 14,334 cases and 346,860 controls to determine genetic susceptibility to coronary atherosclerosis. Random-effects inverse variance weighted (IVW) MR analyses were performed by a series of sensitivity assessments to measure the robustness of our findings and to detect any violations of MR assumptions. …”
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Characterization of novel human endogenous retrovirus structures on chromosomes 6 and 7 by Nicholas Pasternack, Nicholas Pasternack, Ole Paulsen, Avindra Nath

“…Future studies need to determine if these polymorphisms determine genetic susceptibility to diseases that are associated with them.…”
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Kinship and Leprosy in the Contacts of Leprosy Patients: Cohort at the Souza Araújo Outpatient Clinic, Rio de Janeiro, RJ, 1987–2010 by Daiane Santos dos Santos, Nadia Cristina Duppre, Anna Maria Sales, José Augusto da Costa Nery, Euzenir Nunes Sarno, Mariana Andréa Hacker

“…Our findings suggested that both genetic susceptibility and physical exposure play an important role in the epidemiology of leprosy, but it was not possible establishing the role of genetic factor. …”
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Serum Matrix Metalloproteinase-3 in Comparison with Acute Phase Proteins as a Marker of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis by Mahmood M. T. M. Ally, Bridget Hodkinson, Pieter W. A. Meyer, Eustasius Musenge, Mohammed Tikly, Ronald Anderson

“…Matrix metalloproteinase-3 (MMP-3) is involved in the immunopathogenesis of rheumatoid arthritis (RA), but little is known about its relationship to genetic susceptibility and biomarkers of disease activity, especially acute phase reactants in early RA. …”
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Pinus sylvestris bark extract reduces the impact of Heligmosomoides bakeri infection on C57BL/6 but not on BALB/c mice (Mus musculus) by Berit Marie Blomstrand, Stig Milan Thamsborg, Håvard Steinshamn, Heidi Larsen Enemark, Inga Marie Aasen, Karl-Christian Mahnert, Kristin Marie Sørheim, Francesca Shepherd, Jos Houdijk, Spiridoula Athanasiadou

“…The results indicate that the impact of PSMs on parasitized hosts is affected by host's genetic susceptibility, with susceptible hosts benefiting more from bark extract administration compared to resistant ones.…”
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