Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far? by Aleksandra Pyzik, Ewelina Grywalska, Beata Matyjaszek-Matuszek, Jacek Roliński

“…This review of literature attempts to identify the factors that are involved in the pathogenesis of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility accompanied with environmental factors. …”
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Genetic Variants in SNCA and the Risk of Sporadic Parkinson’s Disease and Clinical Outcomes: A Review by Clarissa Loureiro das Chagas Campêlo, Regina Helena Silva

“…There is increasing evidence of the contribution of genetic susceptibility to the etiology of Parkinson’s disease (PD). …”
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Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases by Ya-Min Ma, Lan Zhao

“…In neurodegenerative diseases, in addition to the complex interactions between genetic susceptibility and environmental factors, miRNAs can serve as a promising diagnostic tool for diseases. …”
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Lentiviral-Mediated shRNA Silencing of PDE4D Gene Inhibits Platelet-Derived Growth Factor-Induced Proliferation and Migration of Rat Aortic Smooth Muscle Cells by Lin Liu, Xiaowei Xu, Jiejie Li, Xia Li, Wenli Sheng

“…Our results implicate that PDE4D has an important role in VSMC proliferation and migration which may explain its genetic susceptibility to ischemic stroke.…”
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Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms by Stefan Bidula, Darren W. Sexton, Silke Schelenz

“…Additionally, we will explore the various genetic susceptibility factors that predispose individuals to infection.…”
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True familial aggregation of recurrent furunculosis in families from the Province of Villa Clara by Vicente José Hernández Moreno, Manuela Herrera Martínez

“…Objective: to identify genetic susceptibility in individuals affected by recurrent furunculosis according to the true familial aggregation of the disease in a group of families with affected individuals. …”
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The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…Several genetic factors are involved in OA, including inherited genes, genetic susceptibility, and genetic predisposition. As the pathogenesis of OA is unknown, there are almost no effective treatments available to prevent the onset or progression of the disease. …”
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Obesity as a Major Risk Factor for Cancer by Giovanni De Pergola, Franco Silvestris

“…Various novel candidate mechanisms have been proposed: chronic inflammation, oxidative stress, crosstalk between tumour cells and surrounding adipocytes, migrating adipose stromal cells, obesity-induced hypoxia, shared genetic susceptibility, and the functional defeat of immune function. …”
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Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis by Desiré Casares‐Marfil, Amr H. Sawalha

“…To date, five genome‐wide association studies (GWAS) have been performed in TAK, identifying multiple genetic susceptibility loci across the genome. Here, we summarize the major findings from GWAS in TAK and provide an in silico functional evaluation of the associated loci (P < 5 × 10−8) and variants in high linkage disequilibrium with them (r2 > 0.8). …”
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Environment as a Potential Key Determinant of the Continued Increase of Prostate Cancer Incidence in Martinique by Dominique Belpomme, Philippe Irigaray

“…Since the Caribbean African descent-associated genetic susceptibility factor would have remained constant during the 1980–2005, we suggest that in Martinique some environmental change including the intensive use of carcinogenic organochlorine pesticides might have occurred as key determinant of the persisting highly growing incidence of prostate cancer.…”
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Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes by Donghe Li, Sungho Won

“…The goal of the GWAS is to identify genetic susceptibility to complex diseases by assaying and analyzing hundreds of thousands of single-nucleotide polymorphisms. …”
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Bipolar Disorder and Multiple Sclerosis: A Case Series by Youssef Sidhom, Mouna Ben Djebara, Yosr Hizem, Istabrak Abdelkefi, Imen Kacem, Amina Gargouri, Riadh Gouider

“…MRI lesions suggest the possible implication of local MS-related brain damage in development of pure “psychiatric fits” in MS. Genetic susceptibility is another hypothesis for this association. …”
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Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study. by Luigi Sacchettino, Michele Costanzo, Iolanda Veneruso, Valeria D'Argenio, Maria Mayer, Francesco Napolitano, Danila d'Angelo

“…Such a dysfunctional behavior can be associated with genetic susceptibility, environmental factors, traumatic experiences, and medical conditions. …”
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The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock by Gennaro De Pascale, Salvatore Lucio Cutuli, Mariano Alberto Pennisi, Massimo Antonelli

“…Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest. …”
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Inflammatory Bowel Disease: Progress Towards a Gene by David A van Heel, Jack Satsangi, Alisoun H Carey, Derek P Jewell

“…The pathogenesis of ulcerative colitis (UC) and Crohn’s disease (CD) is still unknown, but the importance of genetic susceptibility has been clearly shown by epidemiological data from family and twin studies. …”
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Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives by Arash Assadsangabi, Caroline A. Evans, Bernard M. Corfe, Alan Lobo

“…Genome-wide association studies (GWAS) and knockout mouse models have significantly advanced our understanding of genetic susceptibility loci and inflammatory pathways involved in IBD pathogenesis. …”
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Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab by Amanjot Kaur Rayat, Pallvi Thapar, Mandeep Kaur, Sukhjashanpreet Singh, Anupam Kaur

“…Conclusion: CYP11A1 variants (rs11632698 and rs4077582) may be useful markers in determining the genetic susceptibility to the pathogenesis of RPL. Keywords: CYP11A1, recurrent miscarriage, recurrent pregnancy loss, rs11632698, rs4077582, spontaneous abortion.…”
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Measuring Measuring iron concentration in the blood samples of some autistic children from Baghdad City by Ezzuldin sulaiman, Hind Suhail Abdulhay

“… Autism spectrum disorder (ASD) research delved into the correlation between genetic susceptibility and various environmental factors, including diet, drug exposure, and environmental toxicants such as exposure to heavy metals. …”
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Myasthenia Gravis Development and Crisis Subsequent to Multiple Sclerosis by Kurosh Gharagozli, Maziar Shojaei, Ali Amini Harandi, Nayyereh Akbari, Manouchehr Ilkhani

“…Furthermore, some evidences support the role of systemic immune dysregulation due to a genetic susceptibility that is common to these two diseases. …”
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Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population by Priti Sharma, Vipin Bihari, Sudhir K. Agarwal, Sudhir K. Goel

“…We studied the effect of genetic susceptibility on hexavalent chromium induced dermal adversities. …”
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