Comprehensive analysis of the 5-HTTLPR allelic polymorphism effect on behavioral and neurophysiological indicators of executive control in people from different ethnic groups in Si... by A. N. Savostyanov, D. V. Bazovkina, S. A. Lashin, S. S. Tamozhnikov, A. E. Saprygin, T. N. Astakhova, U. N. Kavai-ool, N. V. Borisova, A. G. Karpova

“…The allelic polymorphism of the serotonin transporter’s gene 5-HTTLPR is considered as one of the factors determining an individual genetic predisposition to the development of a wide range of affective disorders, including depression. …”
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Coincidental or Connected: Synchronous Giant Gastric GIST and Malignant Colonic Polyp: A Case Report by Terukumar Chandrasekaran, Lim Li Yi, JJ Mah, RK Sriram, Nik Amin Sahid

“…However, it is crucial to consider the possibility of genetic predisposition in patients with such tumors. In a case of GIST, the surgeon should recognize the possibility of another tumor with a different histological origin. …”
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COVID-19 is a risk factor for retinal vein occlusion in younger patients? by A.G. Shchuko, M.V. Akulenko, T.N. Yur’eva

“…Meanwhile, the COVID-19 infection cannot be ruled out as an aggravating factor in a patient with a genetic predisposition to (micro)vascular occlusions.</i> </p> <p> <i><b>Keywords</b>: OCTA, retinal neovascularization, retinal vein occlusion, coagulogram, COVID-19.…”
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Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study by Liaoyi Lin, Yingbao Huang, Songzan Qian, Lifang Chen, Houzhang Sun

“…Some lipid classes showed significant effects both in the FinnGen consortium and UK Biobank datasets.ConclusionsThe findings of this study indicate a potential genetic predisposition linking the plasma lipidome to pancreatic diseases and good prospects for future pancreatic disease clinical trials.…”
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Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia by Ricardo P. P. Moreira, Larissa G. Gomes, Guiomar Madureira, Berenice B. Mendonca, Tânia A. S. S. Bachega

“…Pediatric CAH patients have an increased risk of cardiovascular disease, and it remains unknown if genetic predisposition is a contributing factor. Glucocorticoid receptor gene (NR3C1) polymorphisms are associated with an adverse metabolic profile. …”
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Association of childhood maltreatment and adverse lifetime experiences with post-injury psychopathology: evidence from the China Severe Trauma Cohort by Shu Wen, Yu Zeng, Yueyao Xu, Shishi Xu, Wenwen Chen, Guanglin Wang, Wei Zhang, Huan Song

“…We further stratified the analyses by level of genetic predisposition to a given psychological symptom quantified by polygenic risk score (PRS) based on publicly available GWAS summary statistics. …”
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Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China by Xiaowen Wang, Junhui Wu, Yao Wu, Mengying Wang, Zijing Wang, Tao Wu, Dafang Chen, Xun Tang, Xueying Qin, Yiqun Wu, Yonghua Hu

“…Furthermore, the common genetic predisposition to T2DM and lipids was not fully detected. …”
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Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype by Niloufar Rasaei, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Mahsa Samadi, Mohammad Keshavarz Mohammadian, Elnaz Daneshzad, Khadijeh Mirzaei

“…Environmental changes, such as improving the quality of dietary fat consumed, may be useful in preventing or mitigating the obesity or unhealthy obesity phenotype in individuals with a genetic predisposition, although this has not yet been confirmed. …”
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Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices by Somaya Zahran, Ke Fan Bei, Aisha Adil, Princess Okoh, Thomas Kitzler, Ahsan Alam

“…Although not fully understood, this observation could be partially explained by genetic predisposition to kidney diseases. Genetic testing of potential LKDs may improve risk assessment and inform the safety of donation. …”
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Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes by Fresia Pareja, Rohit Bhargava, Virginia F. Borges, Edi Brogi, Rita Canas Marques, Fatima Cardoso, Christine Desmedt, Malini Harigopal, Sunil R. Lakhani, Adrian Lee, Jose Pablo Leone, Hannah Linden, Christopher J. Lord, Caterina Marchio, Sofia D. Merajver, Emad Rakha, Jorge S. Reis-Filho, Andrea Richardson, Elinor Sawyer, Pepper Schedin, Christopher J. Schwartz, Andrew Tutt, Naoto T. Ueno, Anne Vincent-Salomon, Britta Weigelt, Y. Hannah Wen, Stuart J. Schnitt, Steffi Oesterreich

“…Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. …”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…The following hypotheses have been proposed as the main mechanisms for the development of achalasia: genetic predisposition, exposure to viral infections, and idiopathic autoimmune triggers. …”
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Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model by Tereza Hornikova, Anna Jelinkova, Zuzana Jiraskova Zakostelska, Tomas Thon, Stepan Coufal, Andrea Polouckova, Eliska Kopelentova, Miloslav Kverka, Peter Makovicky, Helena Tlaskalova-Hogenova, Anna Sediva, Martin Schwarzer, Dagmar Srutkova

“…However, the resulting allergic reaction could depend on factors such as the host’s genetic predisposition as well as the skin and gut microbiota.MethodsSpecific-pathogen-free BALB/c and C57BL/6 and germ-free (GF) BALB/c mice were epicutaneously sensitized with ovalbumin (OVA) via dorsal tape-stripped skin and challenged with OVA by intragastric gavage. …”
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Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank by Ting Li, Jing Chen, Yan Zheng, Klodian Dhana, Geng Zong, Yuan Ma, Trudy Voortman, Wei Gan, Yaying Cao, Yonghua Hu, Changzheng Yuan, Jie Shen, Gaohong Zhu, Chengwu Feng

“…The association of cardiovascular risk burden with all-cause dementia is largely independent of CVD onset and genetic predisposition to dementia.…”
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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells by Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J. Clark, Simon J. Clark, Simon J. Clark, Marius Ueffing

“…IntroductionAge-related macular degeneration (AMD), a degenerative disease of the macula, is caused by an interplay of diverse risk factors (genetic predisposition, age and lifestyle habits). One of the main genetic risks includes the Y402H polymorphism in complement Factor H (FH), an inhibitor of complement system activation. …”
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Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions by Vilde Øverlien Dåstøl, Vilde Øverlien Dåstøl, Kristine Løkås Haftorn, Hamid Khoshfekr Rudsari, Piotr Pawel Jaholkowski, Piotr Pawel Jaholkowski, Ketil Størdal, Ketil Størdal, Siri Eldevik Håberg, Siri Eldevik Håberg, Clarice R. Weinberg, Lisa G. Rider, Ole A. Andreassen, Ole A. Andreassen, Ole A. Andreassen, Anne Lise Brantsæter, Ida Henriette Caspersen, Ida Henriette Caspersen, Helga Sanner, Helga Sanner

“…Our data suggest a more pronounced association in children with a lower genetic predisposition for JIA.…”
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The relationship between dietary branched-chain and aromatic amino acids with the regulation of leptin and FTO genes in adipose tissue of patients undergoing abdominal surgery by Farshad Teymoori, Hossein Farhadnejad, Mostafa Norouzzadeh, Mitra Kazemi Jahromi, Niloufar Saber, Ebrahim Mokhtari, Golaleh Asghari, Emad Yuzbashian, Parvin Mirmiran, Alireza Khalaj, Maryam Zarkesh, Mehdi Hedayati, Mohammadreza Vafa

“…Abstract Recent studies have suggested that the interaction between diet and an individual’s genetic predisposition can determine the likelihood of obesity and various metabolic disorders. …”
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DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS by Gabriel Rotundu, Diana Tatarciuc, Bogdan Amărioarei, Dana Budală, Ruxandra Stan, Oana Butnaru, Alexandra Mârțu, Liliana Păsărin, Ionut Luchian

“…This review aims to provide an in-depth analysis of the cellular and molecular pathways implicated in DIGO, including the roles of fibroblasts, inflammatory mediators, and genetic predispositions. By elucidating the interactions between these factors, we seek to highlight potential targets for intervention. …”
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Genetic insights into MIS-C Post-COVID-19 in Kuwaiti children: investigating monogenic factors by Mohammed Dashti, Hessa AlKandari, Hessa AlKandari, Md Zubbair Malik, Rasheeba Nizam, Sumi Elsa John, Sindhu Jacob, Arshad Channanath, Fouzeyah Othman, Safa Al-Sayed, Osama Al-Hindi, Mona Al-Mutari, Thangavel Alphonse Thanaraj, Fahd Al-Mulla

“…The findings highlight the critical role of genetic predispositions in MIS-C and suggest that further functional genomics work is necessary to explore the mechanistic contributions of these genes, facilitating the development of targeted diagnostic strategies.…”
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Benzocaine-Induced Methemoglobinemia in a Postoperative Bariatric Patient following Esophagogastroduodenoscopy by Khuram Khan, Irwin White-Gittens, Saqib Saeed, Leaque Ahmed

“…This is thought to be a disease seen almost exclusively in patients with genetic predispositions to develop it; the increasing use of topical anesthetics during procedures has made methemoglobinemia a disease entity that every clinical provider should be able to recognize and treat. …”
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Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report by Abdul Muhsen Abdeen MD, Jowan Al-Nusair MD, Malik Samardali MD, Mohamed Alshal MD, Amro Al-Astal MD, Zeid Khitan MD

“…Renal biopsy revealed classic TMA features, and genetic testing identified the MCP mutation, underscoring the importance of genetic predispositions in guiding diagnosis and therapy. …”
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