End-stage ADPKD with a low-frequency PKD1 mosaic variant accelerated by chemoradiotherapy by Hiroaki Hanafusa, Hiroshi Yamaguchi, Naoya Morisada, Ming Juan YE, Riki Matsumoto, Hiroaki Nagase, Kandai Nozu

“…This case highlights how environmental factors may contribute to the genetic predisposition to ADPKD.…”
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Type 2 Diabetes Mellitus in a 15 Years Old Adolescent: Case Report and Literature Review by Blanca Cristina Estrella López, Roberto Javier Aguilar Berrezueta, Silvio Amable Machuca Vivar

“…The main risk factors for suffering from it in adolescents are: obesity, genetic predisposition and family history. The case of a 15-year-old female patient who attended health services with a previous diagnosis of prediabetes and overweight is presented. …”
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Dandy-Walker Syndrome. Case Report and Literature Review by William Ernesto González Águila, Osiris Intento García, Nilda Beatriz Cortizo Martínez

“…It is mainly based on an abnormal development of the cerebrospinal fluid communication pathways. Genetic predisposition associated with malformations and chromosomal alterations has been suggested. …”
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Review of NVP and HG and Early Pharmacotherapeutic Intervention by Shannon M. Clark, Maged M. Costantine, Gary D. V. Hankins

“…The most common etiologies for NVP include the hormonal changes associated with pregnancy, the physiologic changes in the gastrointestinal tract, and a genetic predisposition. Up to 10% of women will require pharmacotherapy to treat the symptoms of NVP despite conservative measures. …”
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Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy by Yu. B. Uspenskaya, A. A. Sheptulin

“…The etiology and pathogenesis of ICP are related to disorders of bile acid metabolism caused by hormonal factors (elevation of estrogen and progesterone levels) and genetic predisposition. The leading clinical signs of ICP include pruritus and jaundice that develop most commonly in the third trimester of pregnancy, and characteristic changes of laboratory scores: increase in bile acid level (over 10 mcmol/l) and moderate elevation of transaminase activity. …”
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Signaling Pathway Puts the Break on Fat Cell Formation by Ormond A. MacDougald

“…These environmental factors may be complicated in some individuals by an unfavorable genetic predisposition. Pharmaceutical companies lead active research programs to identify drugs that target weight control centers in the body and which may help individuals control their weight; however, no satisfactory magic bullet to fight obesity has yet come through the pipeline [7,8].…”
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Diagnosis and Treatment of Paracoccidioidomycosis in the Maxillofacial Region: A Report of 5 Cases by Antonio Dionízio De Albuquerque Neto, André Vitor Alves Araújo, Daniel Assunção Cerqueira, Lorenzzo De Angeli Cesconetto, Nilton Provenzano, Eder Magno Ferreira de Oliveira

“…Manifestation of this disease depends on numerous factors, such as microorganism virulence, hormonal profile, genetic predisposition, nutrition, and immune system. It is characterized classically by cutaneous lesions, lymphadenopathy, and pulmonary involvement. …”
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Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences by Kyung E. Rhee, Suzanne Phelan, Jeanne McCaffery

“…By helping parents and young children change certain behaviors and exposures during critical time periods, we may be able to alter or modify one’s genetic predisposition. However, further research is needed to determine which efforts are effective at decreasing the incidence of obesity and to develop new methods of prevention. …”
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Natural Killer Cell and Large Granular Lymphocyte Deficiency in the Gut of Children with Inflammatory Bowel Disease by F Hadziselimovic, LR Emmons, U Schaub

“…The lack of natural killer cells and LGL in the gut epithelium in children with IBD may be indicative of a possible genetic predisposition. The authors also present a new therapeutic strategy consisting of low dose interferon-alpha-2a that is efficacious in ameliorating ulcerative col iris and Crohn's disease and concomitantly increasing the number of natural killer cells and LGL in the gut.…”
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Construction of an Integrated Positive Youth Development Conceptual Framework for the Prevention of the Use of Psychotropic Drugs among Adolescents by Tak Yan Lee

“…Theories of drug use and abuse, including neurological, pharmacological, genetic predisposition, psychological, and sociological theories, were reviewed. …”
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Torsades de Pointes due to Excessive Marijuana Use in a Susceptible Patient by Vivek D. Shah, Adeba Mohammad, Shuktika Nandkeolyar, Liset Stoletniy, Tahmeed Contractor

“…While she demonstrated normal baseline QTc measurements years earlier, she was found to have a genetic predisposition to QTc prolongation (genetic mutation, family history of prolonged QTc), suggesting that specific patient populations are at higher risk of these adverse events. …”
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New horizons in the treatment of psoriasis: Modulation of gut microbiome by Mojtaba Memariani, Hamed Memariani

“…Psoriasis is a complex disease with multiple factors contributing to its development, such as diet, lifestyle, genetic predisposition, and the microbiome. This paper has a dual purpose. …”
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Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus by Jolanta Dorota Torzecka, Joanna Narbutt, Anna Sysa-jedrzejowska, Maciej Borowiec, Anetta Ptasinska, Grzegorz Woszczek, Marek L. Kowalski

“…The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. …”
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Asthma and Atopic Diseases in Children with Autism Spectrum Disorders by Khaled Saad, Mohamed Ezzat, Amira Elhoufey, Mahmoud Elsaeed Ahmed, Abdulrahman A. Al-Atram, Mohsen M. Fageeh, Yasser Hamed

“…Conclusion: Allergic diseases are complex conditions influenced by both genetic predisposition and environmental factors, which play pivotal roles in their development. …”
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Febrile Seizures and Febrile Seizure Syndromes: An Updated Overview of Old and Current Knowledge by Abdulhafeez M. Khair, Dalal Elmagrabi

“…Their etiology and pathophysiological pathways are being understood better over time; however, there is still more to learn. Genetic predisposition is thought to be a major contributor. …”
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The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…Several genetic factors are involved in OA, including inherited genes, genetic susceptibility, and genetic predisposition. As the pathogenesis of OA is unknown, there are almost no effective treatments available to prevent the onset or progression of the disease. …”
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Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions by Diletta Bonciani, Alice Verdelli, Veronica Bonciolini, Antonietta D'Errico, Emiliano Antiga, Paolo Fabbri, Marzia Caproni

“…There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. …”
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Hereditary colorectal cancer: genetics and screening diagnostics by O. I. Kit, D. I. Vodolazhsky, Yu. A. Gevorkyan, N. V. Soldatkina, F. N. Grechkin, M. A. Kozhushko, I. Yu. Yefimova

“…In 30% of cases disease development is associated to genetic predisposition, however only 5% of all CRC cases are linked to established hereditary syndromes, such as Lynch syndrome (hereditary non-polyposis colorectal cancer), family adenomatous polyposis, MUTYH-associated polyposis, juvenile polyposis, hereditary mixed polyposis syndrome, Peutz-Jeghers syndrome and serrated polyposis syndrome. …”
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Polymorphism of genes and drug-induced liver injury by P. Ye. Tkachenko, M. V. Mayevskaya, V. T. Ivashkin

“…The most cases are related to idiosyncrasy phenomenon which is based on genetic predisposition for production of reactive metabolites at xenobiotic transformation reactions in the liver. …”
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Inflammatory Bowel Disease in Indo-Canadians with and without Antineutrophil Cytoplasmic Autoantibodies by Hugh James Freeman

“…This study supports the view that these diseases arise in individuals with a genetic predisposition following exposure to some, as yet unknown, environmental factor.…”
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