Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Alexandra Noble, Rodrigo Motta, Silvia Cabras, Belen Moron Flores, Jan Nowak, Aleksandra Glapa-Nowak, Alessandra Geremia, Jack Satsangi, Emma Culver

“…Epigenetic age acceleration was observed in patients with IgG4-SC, but not in those with PSC or UC. meQTL analyses to identify genetic determinants of methylation revealed a strong human leucocyte antigen (HLA) signal in both PSC and IgG4-SC (HLA-DQB2, HLA-DPA1, HLA-F and HLA-DRA). …”
Get full text

Auditory Phenotype of a Novel Missense Variant in the CEACAM16 Gene in a Large Russian Family With Autosomal Dominant Nonsyndromic Hearing Loss by Tatiana G. Markova, Natalia N. Alekseeva, Oxana P. Ryzhkova, Olga L. Shatokhina, Anna A. Orlova, Viktoriia V. Zabnenkova, Olga S. Groznova, Olesya V. Sagaydak, Svetlana S. Chibisova, Alexander V. Polyakov, George A. Tavartkiladze

“…BACKGROUND: Autosomal dominant hearing loss is represented by a large number of genetically determined forms. Over 50 genes associated with dominant nonsyndromic hearing impairments were described. …”
Get full text

Relationships between the allozyme and phenotypic diversities of Picea ajanensis populations by V. P. Vetrova, A. K. Ekart, A. N. Kravchenko, A. Ya. Larionova

“…This observation was consistent with the genetic determination of the shape of cone scales in spruce. …”
Get full text

Comparative Genomic Analysis of <i>Campylobacter</i> Plasmids Identified in Food Isolates by Yiping He, Gretchen Elizabeth Dykes, Siddhartha Kanrar, Yanhong Liu, Nereus W. Gunther, Katrina L. Counihan, Joe Lee, Joseph A. Capobianco

“…Together, the identification and comprehensive genetic characterization of new plasmids from <i>Campylobacter</i> food isolates contributes to understanding the mechanisms of gene transfer, particularly the spread of genetic determinants of virulence and antibiotic resistance in this important pathogen.…”
Get full text

Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescentsResearch in context by Yun Huang, Sara Elizabeth Stinson, Malte Thodberg, Louise Aas Holm, Roman Thielemann, Karolina Sulek, Morten Asp Vonsild Lund, Cilius Esmann Fonvig, Min Kim, Kajetan Trost, Helene Bæk Juel, Trine Nielsen, Peter Rossing, Maja Thiele, Aleksander Krag, Cristina Legido-Quigley, Jens-Christian Holm, Torben Hansen

“…Interpretation: These findings highlight the potential long-term implications of plasma lipid genetic determinants on cardiometabolic risk. Funding: Novo Nordisk Foundation, The Innovation Fund Denmark, The Danish Heart Foundation, EU Horizon, and LundbeckFonden.…”
Get full text

Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization. by William B Messer, Boyd Yount, Kari E Hacker, Eric F Donaldson, Jeremy P Huynh, Aravinda M de Silva, Ralph S Baric

“…The recombinant and synthetic tools described here are valuable for testing hypotheses on genetic determinants of DENV-3 immunopathogenesis.…”
Get full text

The study of genetic factors that determine the awned glume trait in bread wheat by O. B. Dobrovolskaya, A. E. Dresvyannikova, E. D. Badaeva, K. I. Popova, M. Trávníčková, P. Martinek

“…Features of the awned glume development and the genetic determinants of this trait have been little studied. …”
Get full text

The Krushinsky – Molodkina genetic rat strain as a unique experimental model of seizure states by I. I. Poletaeva, Z. A. Kostyna, N. M. Surina, I. B. Fedotova, Z. A. Zorina

“…Accumulation of knowledge concerning the functions of genes, which are expressed in the CNS and are involved in the specific brain functions determined now by the success of molecular genetics, but it could not overshadow the importance of phenotype expression investigation of genetically determined traits, especially pathological ones. …”
Get full text

Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia by N. Yu. Chasovskikh, A. A. Bobrysheva, E. E. Chizhik

“…It has also been established that genetically determined changes in IL-1 can contribute to schizophrenia, thereby confirming the role of the IL-1 gene cluster in disease susceptibility. …”
Get full text

Genome-wide association study for charcoal rot resistance in soybean harvested in Kazakhstan by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, A. Maulenbay, C. Fang, Y. Turuspekov

“…In this research, we conducted a genome-wide association study (GWAS) using different models and genotypic data to unravel the genetic determinants underlying soybean resistance to сharcoal rot. …”
Get full text

Analysis of polymorphism at the <i>FaRca1</i> locus to identify strawberry genotypes resistant to <i>Colletotrichum acutatum</i> by A. S. Lyzhinir, I. V. Luk’yanchuk

“…The employment of cultivars with genetically determined resistance will minimize the use of chemical means of plant protection and increase the produce quality. …”
Get full text

The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary. by Laurence Drouilhet, Camille Mansanet, Julien Sarry, Kamila Tabet, Philippe Bardou, Florent Woloszyn, Jérome Lluch, Grégoire Harichaux, Catherine Viguié, Danielle Monniaux, Loys Bodin, Philippe Mulsant, Stéphane Fabre

“…In the Lacaune sheep breed, large variation in litter size is genetically determined by the segregation of a fecundity major gene influencing ovulation rate, named FecL and its prolific allele FecL(L) . …”
Get full text

Thrombogenic Markers in Patients with Hereditary Thrombophilia by Karima Maricel Gondres Legró, Jorge Calá Fernández, Yusmairy Matos Lores, Vivian Robert Tamayo, Lázaro Ibrahim Romero García, Yordanys Páez Candelaria

“…<strong>Foundation:</strong> hereditary thrombophilia is defined as the genetically determined tendency to venous thromboembolism, an entity with a significant incidence worldwide. …”
Get full text

Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study by Zhuyuan Zheng, Shaojie Yang, Wanlin Dai, Yang Sun, Jingnan Wang, Xiaolin Zhang, Yiming Zheng, Jing Kong

“…Furthermore, we used mediation analysis to assess whether the effect of plasma lipidome on NAFLD was mediated by plasma metabolome.ResultsThe MR analysis predicted a genetically determined causal relationship between plasma lipidomes and NAFLD. …”
Get full text

Enhanced Visual Attentional Modulation in Patients with Inherited Peripheral Retinal Degeneration in the Absence of Cortical Degeneration by Sónia Ferreira, Andreia Carvalho Pereira, Bruno Quendera, Aldina Reis, Eduardo Duarte Silva, Miguel Castelo-Branco

“…Our study was aimed at determining the effect of genetically determined peripheral retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested the recruitment of attentional mechanisms using functional magnetic resonance imaging (fMRI). …”
Get full text

The role of VNTR aggrecan gene polymorphism in the development of osteoarthritis in women by D. A. Shapovalova, A. V. Tyurin, S. S. Litvinov, E. K. Khusnutdinova, R. I. Khusainova

“…Undifferentiated connective tissue dysplasia (uCTD) is a genetically determined lesion of the connective tissue structures, including joints, and it can be one of the factors predisposing to development of OA. …”
Get full text

Lipoprotein(a) and thromboembolism: current state of knowledge and unsolved issues by Małgorzata Konieczyńska, Joanna Natorska, Michał Ząbczyk, Anetta Undas

“…Lipoprotein(a) [Lp(a)], a low-density lipoprotein-like particle containing a highly polymorphic apolipoprotein(a) [apo(a)] homologous in > 80% to plasminogen, was identified as a genetically determined independent risk factor for cardiovascular disease. …”
Get full text

Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk by Wenxi Sun, Ping Sun, Jin Li, Qun Yang, Qing Tian, Shiting Yuan, Xueying Zhang, Peng Chen, Chuanwei Li, Xiaobin Zhang

“…MR analysis revealed significant genetically determined causal associations between ETHE1 (OR: 1.06), SOD (OR: 0.97), CALU3 (OR: 1.03), and C1QBP (OR: 1.05) and SCZ. …”
Get full text

Genetic markers of children asthma: predisposition to disease course variants by M. V. Smolnikova, Ed. W. Kasparov, M. A. Malinchik, K. V. Kopylova

“…Asthma is a multifactorial disease with a significant genetic determinant, however, the inheritance of asthma has not been fully elucidated. …”
Get full text

Comprehensive Hematological and molecular Characterization of hemoglobin Hekinan [α27(B8)Glu→Asp(α1), HBA1:c.84G > T] in a Large Thai cohort by Amornchai Suksusut, Jidapa Jaitheang, Manussavee Prapphal, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Noppacharn Uaprasert

“…Hb Hekinan was confirmed by direct DNA sequencing. Additional genetic determinants, including α-thalassemia, β-thalassemia and other variants, were detected using multiplex GAP-PCR, ARMS-PCR or direct DNA sequencing as appropriate.Results: Among 61,997 Hb typing samples, 149 cases of Hb Hekinan were identified in Thai individuals and classified into 8 genotypic groups. …”
Get full text