The Conservative Physiology of the Immune System. A Non-Metaphoric Approach to Immunological Activity by Nelson M. Vaz, Gustavo C. Ramos, Vitor Pordeus, Claudia R. Carvalho

“…In the late 50s, selective theories were proposed and from then on, immunology has been based in a close association with the neo-Darwinian principles, such as random generation of variants (lymphocyte clones), selection by extrinsic factors (antigens)—and, more generally, on genetic determinism and functionalism. This association has had major consequences: (1) immunological jargon is full of “cognitive” metaphors, founded in the idea of “foreignness”; (2) the immune system is described with a random clonal origin, coupled to selection by random encounters; and (3) physiological events are virtually absent from immunological descriptions. …”
Get full text

Variability of morphometrical characteristics of needles at a clonal plantation of plus trees of scots pine (Pinus sylvestris L.) by N. N. Besschetnova, V. P. Besschetnov

“…Pronounced heterogeneity of the composition and its genetic determinism set up conditions for effective multivariate comparisons of plus trees. …”
Get full text

Genetic approaches to the investigation of serotonergic neuron functions in animals by U. S. Drozd, E. V. Shaburova, N. N. Dygalo

“…The selective cell control is possible due to the genetic determinism of their functions. Proteins that determine the uniqueness of the cell type are expressed under the regulation of cell-specific promoters. …”
Get full text

Genome-Wide Association Study of Coronary Artery Disease by Naomi Ogawa, Yasushi Imai, Hiroyuki Morita, Ryozo Nagai

“…Coronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. …”
Get full text

Loeys-Dietz syndrome by Bogumiła Wójcik-Niklewska, Erita Filipek

“…Loeys-Dietz syndrome is a rare syndrome of genetically determined congenital defects characterized by specific dysmorphic features, vascular tortuosity, aneurysms, mitral valve disease, and bone abnormalities. …”
Get full text

Role of autophagy defects and significance of adherent-invasive <i>Escherichia coli</i> in Crohn's disease development by I. V. Mayev, D. N. Andreev, D. V. Rakitina, Yu. P. Baykova

“…Alteration of autophagy process (defects of NOD2/ CARD15, ATG16L1, IRGM genes) is one of genetically determined disorders of innate immunity typical for CD. …”
Get full text

New aspects of non-alcoholic fatty liver disease by V. V. Tsukanov, E. V. Kasparov, Yu. L. Tonkikh, A. V. Vasyutin

“…Now concepts on genetic determinants of NAFLD and diagnostics methods develop rapidly. …”
Get full text

Evolutionary Explanations of the “Actuarial Senescence in the Wild” and of the “State of Senility” by Giacinto Libertini

“…For IMICAW, it should be substituted with the concept of a physiologic phenomenon genetically determined by a balance of opposite selective pressures — strictly in terms of kin selection — and, for “age changes”, with the action of the same IMICAW-causing mechanisms at ages when selection becomes ineffective.…”
Get full text

Epigenetic variation in light of population genetic practice by Sarah A. Mueller, Justin Merondun, Sonja Lečić, Jochen B. W. Wolf

“…Abstract The evolutionary impact of epigenetic variation depends on its transgenerational stability and source - whether genetically determined, environmentally induced, or due to spontaneous, genotype-independent mutations. …”
Get full text

Modulation de l’expression vocale des primates en fonction des contraintes socio-écologiques by Jean‑Pierre Gautier

“…As vocalizations are genetically determined, close phylogenetic species possess the same repertoire of homologous different calls. …”
Get full text

Polymorphic loci of coat color in mini-pigs by S. V. Nikitin, K. S. Shatokhin, S. P. Knyazev, G. M. Goncharenko, V. I. Zaporozhets, V. I. Ermolayev

“…The research allowed us to put forward some assumptions concerning the genetic determination of the phenotypic characteristics of color seen in the study group selection. …”
Get full text

Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population by Lung-An Hsu, Ming-Sheng Teng, Semon Wu, Mei-Siou Liao, Hsin-Hua Chou, Yu-Lin Ko

“…However, prediction of long-term outcome using circulating resistin level and its genetic determinants in a population-based study remain to be explored. …”
Get full text

Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review by Francesco M Marincola, Alessandra Cesano, Yana G Najjar, Davide Bedognetti, Marco Ruella, Sarah Warren, Christine Spencer, Elad Ziv, Tomas Kirchhoff, Jennifer McQuade, Tullia C Bruno, Jakob Nikolas Kather, Allison Betof Warner, Christian Hammer, Alberto Carturan, Ryan Augustin, Rhine Shen, Winson S Ho, Rongze O Lu, Luigi Barrea, Violena Pietrobon, Laura Soldati

“…However, most patients with cancer do not benefit from the rapidly evolving improvements in the understanding of principal mechanisms determining cancer immune responsiveness (CIR); including patient-specific genetically determined and acquired factors, as well as intrinsic cancer cell biology. …”
Get full text

Celiac disease: Overview and considerations for development of gluten-free foods by Prakriti Jnawali, Vikas Kumar, Beenu Tanwar

“…Celiac disease is a genetically-determined chronic inflammatory intestinal disease induced by gluten in wheat, barley, rye etc. …”
Get full text

Antibiotic Resistance of Enterobacteriaceae in Microbiomes Associated with Poultry Farming by Anna S. Krivonogova, Irina M. Donnik, Albina G. Isaeva, Egor A. Loginov, Maxim V. Petropavlovskiy, Elisey N. Bespamyatnykh

“…As a result, Escherichia, Enterobacter, Klebsiella, and Proteus in avian microbiomes have become reservoirs for genetic determinants of resistance, thus spreading resistance to antibiotics and contaminating raw materials and finished products. …”
Get full text

How Ornamental Fish Get Their Color by Frank A. Chapman, Richard D. Miles

“… Color in fish is mostly genetically determined, but they are unable to produce red, orange, yellow, green, and some blue colors themselves. …”
Get full text

Empirical Evidence for Various Evolutionary Hypotheses on Species Demonstrating Increasing Mortality with Increasing Chronological Age in the Wild by Giacinto Libertini

“…In particular, (1) the existence of many species with a constant, or almost constant, mortality rate, especially the so-called “animals with negligible senescence”; (2) the inverse correlation, observed in mammals and birds in the wild, between extrinsic mortality and the proportion of deaths due to intrinsic mortality; (3) the existence of highly sophisticated, genetically determined, and regulated mechanisms that limit and modulate cell duplication capacities and overall cell functionality. …”
Get full text

How Ornamental Fish Get Their Color by Frank A. Chapman, Richard D. Miles

“… Color in fish is mostly genetically determined, but they are unable to produce red, orange, yellow, green, and some blue colors themselves. …”
Get full text

Multiple resistance factors collectively promote inoculum-dependent dynamic survival during antimicrobial peptide exposure in Enterobacter cloacae. by Andrew N Murtha, Misha I Kazi, Eileen Y Kim, Facundo V Torres, Kelly M Rosch, Tobias Dörr

“…Here, we evaluate the genetic determinants of resistance to an insect AMP, cecropin B, in the opportunistic pathogen Enterobacter cloacae. …”
Get full text

From flower to fruit: fruit growth and development in olive (Olea europaea L.)—a review by Adolfo Rosati, Enrico Maria Lodolini, Franco Famiani

“…It is concluded that the different mechanisms regulating the different phases of fruit development, from pistil abortion to fruit set and fruit size, can be considered as different aspects of the same overall strategy, that is, adjusting fruit load to the available resources while striving to achieve the genetically determined fruit size target and the male and female fitness targets.…”
Get full text