Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade... by Lucie Heinzerling, Michael Fluck, Caroline Robert, Celeste Lebbe, Erika Richtig, Sven D Koch, Ulrike Gnad-Vogt, Tobias Seibel, Thomas Eigentler, Juan Martin-Liberal, Sebastian Ochsenreither, Peter Mohr, Patrick Terheyden, Carsten Weishaupt, Michael Erdmann, Lukas Koch, Ainara Soria, Igor Samoylenko, Jürgen Krauß, Peter Brossart, Franz Georg Bauernfeind, Marina Gonzalez, Peter Wengenmayer, Ioannis Thomas, Artem Poltoratskiy, Marina Sekacheva, Beate Schmitt-Bormann, Gianluca Quintini, Martin Falk, Paula Codó, Arjun Oberoi, Jana Hess, Yulia Semiletova, Casilda Llacer Perez, Oliver Schönborn-Kellenberger

“…In the expansion cohorts in patients with anti-PD-1 therapy-refractory melanoma, 0/10 patients treated with CV8102 as monotherapy and 5/30 patients (17%) treated in combination with a PD-1 inhibitor experienced objective responses.Conclusions IT CV8102 was generally well tolerated with preliminary signs of efficacy as monotherapy and in combination with a PD-1 inhibitor.Trial registration number NCT03291002.…”
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An analysis of heavy metals contamination and estimating the daily intakes of vegetables from Uganda by Keneth Iceland, Kasozi, Eric Oloya, Otim, Herbert Izo, Ninsiima, Gerald, Zirintunda, Andrew, Tamale, Justin, Ekou, Grace Henry, Musoke, Robert, Muyinda, Kevin, Matama, Regan, Mujinya, Henry, Matovu, Fred, Ssempijja, Ejike, Daniel Eze, Mauryn, Atino, Bede, Udechukwu, Ronald, Kayima, Patrick, Etiang, Emmanuel Tiyo, Ayikobua, Stellamaris, Kembabazi, Ibe Michael, Usman, Sheu Oluwadare, Sulaiman, Phyllis Candy, Natabo, Grace Nambatya, Kyeyune, Gaber El-Saber, Batiha, Ochan, Otim

“…Pb, Cr 6þ, Cd, and Ni for instance are generally considered nonessential to cellular functions, notwithstanding the importance of the oxidative state of the metals in bioavailability. …”
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Level of and trends in women’s empowerment inequalities in antenatal care services in Ethiopia: further analysis of the Ethiopia demographic and health surveys, 2000-16 by Gebretsadik Shibre, Wubegzier Mekonnen, Damen Haile Mariam

“…The Oaxaca-type decomposition technique was applied to investigate social determinants’ role on the change in the disparities between 2000 and 2016. A generalized linear regression model was used for the analyses. …”
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Beyond reliability: assessing rater competence when using a behavioural marker system by Samantha Eve Smith, Scott McColgan-Smith, Fiona Stewart, Julie Mardon, Victoria Ruth Tallentire

“…Abstract Background Behavioural marker systems are used across several healthcare disciplines to assess behavioural (non-technical) skills, but rater training is variable, and inter-rater reliability is generally poor. Inter-rater reliability provides data about the tool, but not the competence of individual raters. …”
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Attention-enhanced optimized deep ensemble network for effective facial emotion recognition by Taimoor Khan, Muhammad Yasir, Chang Choi

“…EA-Net can accurately recognize facial emotions and exhibits strong generalization capabilities even in resource-constrained environments. …”
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Problematic issues of Criminal and Criminal Procedural Legislation in Applying Coercive Medical Measures by D. V. Turenko

“…In the absence of at least one of the elements of the specified structure, coercive medical measures cannot be applied. The author made generalization, based on the initial provision that the main component of criminal liability is the conviction of a person, the adoption of a court conviction, which provides a legal assessment of the act and the specific person who committed it. …”
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Effect of cassava (Manihot esculenta Crantz) varieties on leaf bud sprouting for rapid multiplication of planting materials by Ngakwi Masai Meibuko, Hosea Dunstan Mtui, Anna Baltazari

“…The use of coco peat and peat moss media generally led to early and more successful sprouting. …”
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Detection of Masses in Mammogram Images Based on the Enhanced RetinaNet Network With INbreast Dataset by Wang M, Liu R, Luttrell IV J, Zhang C, Xie J

“…Additionally, we introduced transfer learning techniques into training process through leveraging pre-trained weights from other RetinaNet applications, and fine-tuned our improved model using the INbreast dataset.Results: The aforementioned innovations facilitate superior performance of the enhanced RetiaNet model on the public dataset INbreast, as evidenced by a mAP (mean average precision) of 1.0000 and TPR (true positive rate) of 1.00 at 0.00 FPPI (false positive per image) on the INbreast dataset.Conclusion: The experimental results demonstrate that our enhanced RetinaNet model defeats the existing models by having more generalization performance than other published studies, and it can also be applied to other types of patients to assist doctors in making a proper diagnosis. …”
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Dephrasal adjectives in Polish – A case of syntax-inside-morphology by Joanna Kolbusz-Buda

“…In what follows, we explore the thus far unstudied territory of dephrasal adjectives, such as tużpopołudniowy ‘right-after-noon’ and ponadstustronicowy ‘over-one-hundred-page’ built on phrasal bases subjected to suffixation. It is generally acknowledged that the Polish word-formation system is not designed to comprise phrasal compounding – a word-formation type which has come to be considered a flagship representative of the morphology-syntax interface (see Szymanek 2017 and Pafel 2017). …”
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Climate change and its impacts on hydrological regimes over the Bengal delta by M.H. Ali, P. Biswas, S.M.Q. Hassan, M.A. Islam

“…Under SSP8.5, the magnitude of variation of the parameters is generally higher than those of SSP4.5. The dry winter period is getting drier and falls under semi-arid to hyper-arid categories according to the drought indices. …”
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Risk factors associated with poor pain outcomes following primary knee replacement surgery: Analysis of data from the clinical practice research datalink, hospital episode statisti... by Hasan Raza Mohammad, Rachael Gooberman-Hill, Antonella Delmestri, John Broomfield, Rita Patel, Joerg Huber, Cesar Garriga, Christopher Eccleston, Rafael Pinedo-Villanueva, Tamer T Malak, Nigel Arden, Andrew Price, Vikki Wylde, Tim J Peters, Ashley W Blom, Andrew Judge

“…Results are presented as relative risk ratios and adjusted risk differences (ARD) by fitting a generalized linear model with a binomial error structure and log link function.…”
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Study of Financial Management Behavior Based on Financial Self-Efficacy and Financial Literacy in Small-Scale Agribusiness Development by Fithriah Napu, Dedy Takdir Syaifuddin

“…Farmers' businesses are generally classified as small businesses. Various theoretical evidence is sufficient to explain the important role of farmers in agribusiness development which is limited by financial literacy, and financial self-efficacy that influences financial management behavior. …”
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Polymorphisms in genes related to inflammation and endothelial function are associated with ischemic stroke and other vascular events in populations at high risk of stroke by Hong Chen, Hua Luo, Ju Zhou, Ming Yu, Ting Qing, Yanfen Wang, Minjie Shao, Wei Wei, Xingyang Yi

“…Significant variations have been found in the genotype distributions of TLR4 rs752998, IL6R rs4845625, and TNF rs3093662 among participants with adverse outcomes compared to those without. Generalized multifactor dimensionality reduction (GMDR) analysis identified a substantial SNP-SNP interaction involving HABP2 rs932650, TLR4 rs1927911, and IL6R rs4845625 ( P = .004). …”
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بررسی دوره بازگشت و احتمال رخداد بارش در ایران بر اساس پایگاه داده بارش همادی-وزنی چند منبعی (MSWEP) by آذر زرین, عباسعلی داداشی رودباری

“…بیشینه عدم قطعیت در احتمال رخداد بارش روزانه در مناطق کوهستانی ایران مشاهده شد. [1] Multi-Source Weighted-Ensemble Precipitation (MSWEP)[2] Generalized Extreme Value (GEV)…”
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The interrelation of students’ ideas about fatherhood with gender, age and structure of valuable orientations by S. V. Merzlyakova, M. G. Golubeva, N. V. Bibarsova

“…The image of the ideal father is generally characterised by fragmentary and incomplete representations, and, in some cases, by cognitive distortions.Scientific novelty of the research is to reveal the interrelation of ideas about fatherhood with the structure of valuable orientations of young men and women in adolescence and early adulthood.Practical significance. …”
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Disability of military personnel in Ukraine for 2014-2022 by I.Y. Khanyukova, N.O. Hondulenko, N.A. Sanina

“…For that, the study's authors developed a separate form of statistical reporting, entitled: "Report on the causes of disability, indications for medical, professional and social rehabilitation of ATO participants for _____ year." Generally accepted methods of mathematical descriptive statistics were used for processing. …”
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Machine Learning and Intelligent Diagnostics in Dental and Orofacial Pain Management: A Systematic Review by Taseef Hasan Farook, Nafij Bin Jamayet, Johari Yap Abdullah, Mohammad Khursheed Alam

“…Patient-perceived symptoms and clinical history were generally found to be less reliable than radiographs or histology for training accurate machine learning models. …”
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Outpatient chemotherapy drug costs and expensive chemotherapy drug use in 340B and Non-340B hospitals: an observational study by Jianhui Hu, David R. Nerenz

“…Independent relationships between overall Part B drug costs and patients’ 340B status, and between patients’ use of expensive chemotherapy drug and patients’ 340B status were evaluated in multivariate analyses, using a “stepwise” generalized estimating equation modeling approach. Results We found that patients at 340B hospitals had a somewhat higher chance of using one of the ten expensive chemotherapy drugs, and somewhat higher overall drug costs, but these relationships became non-significant when patient, cancer/clinical factors, and cancer center status were considered. …”
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Cost-effectiveness of oral versus injectable disease modifying therapies in relapsing multiple sclerosis: a systematic review analysis by Mehdi Rezaee, Ramin Ravangard, Seyyed Morteza Mojtabaeian, Abdosaleh Jafari

“…The QHES scores for all records were generally high (≥ 77) and they were of good quality. …”
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The essence and purpose of the social state in the context of the legal experience of modern Ukraine: theoretical and legal analysis by S. S. Polesov

“…It is presented in the Constitution of Ukraine in an extremely generalized form, without specifying the manifestations of the social state, its features, functions, tasks, etc. …”
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