The GWAS-MAP platform for aggregation of results of genome-wide association studies and the GWAS-MAP|homo database of 70 billion genetic associations of human traits by T. I. Shashkova, D. D. Gorev, E. D. Pakhomov, A. S. Shadrina, S. Zh. Sharapov, Y. A. Tsepilov, L. C. Karssen, Y. S. Aulchenko

“…While the amount of GWAS summary statistics collected by the scientific community is rapidly increasing, the use of this data is limited by the lack of generally accepted standards. In particular, the researchers who would like to use GWAS summary statistics in their studies have to become aware that the data are scattered across multiple websites, are presented in a variety of formats, and, often, were not quality controlled. …”
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CHARACTERISTICS OF THE COURSE OF LEUCOCYTOCLASTIC VASCULITIS WITH SKIN LESIONS. ANALYSIS OF CLINICAL CASES by O.A. Borzykh, O.V. Belan, I.A. Mormol, Y.M. Avramenko, T. Іengalychev, T.M. Markina

“…The differential diagnostics enabled us to diagnose LCV in 2 cases, in one case – generalized urticaria due to taking furazolidone. It should be noted that drug reactions with skin lesions constitute a serious medical problem, whose relevance is increasing every year. …”
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Quo vadis autoimmune hepatitis? - Summary of the 5th international autoimmune hepatitis group research workshop 2024Keypoints by Bastian Engel, David N. Assis, Mamatha Bhat, Jan Clusmann, Joost PH. Drenth, Alessio Gerussi, María-Carlota Londoño, Ye Htun Oo, Ida Schregel, Marcial Sebode, Richard Taubert

“…Although standard treatment with corticosteroids and thiopurines improves the life expectancy of patients with AIH, remission rates and tolerability are generally overestimated and the development of alternative first-line and salvage therapies has been disappointingly slow compared to in rheumatological diseases or inflammatory bowel disease. …”
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A Hybrid Model for Psoriasis Subtype Classification: Integrating Multi Transfer Learning and Hard Voting Ensemble Models by İsmail Anıl Avcı, Merve Zirekgür, Barış Karakaya, Betül Demir

“…The dataset includes 930 images labeled by expert dermatologists from the Dermatology Clinic of Fırat University Hospital, representing four distinct subtypes: generalized, guttate, plaque, and pustular. Class imbalance was addressed by applying synthetic data augmentation techniques, particularly for the rare subtype. …”
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Modeling Geomagnetically Induced Currents in the Alberta Power Network: Comparison and Validation Using Hall Probe Measurements During a Magnetic Storm by Darcy Cordell, Ian R. Mann, Hannah Parry, Martyn J. Unsworth, Ryan Cui, Colin Clark, Eva Kelemen, Ryan MacMullin

“…The model performs reasonably well (correlation coefficients >0.5; performance parameter >0.15) at four of five substations, but generally underestimates peak GIC values (sometimes by a factor >2), suggesting that the present model underrepresents overall network risk. …”
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Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging by Chen Zhu, Youfa Wang, Xiaosong Yang, Qiran Zhao, Wenyan Xu, Xiaolu Wang, Yanjun Liang, Qihui Chen, Shenggen Fan

“…Results Our results show that healthier diets are generally associated with improved aging outcomes from HDFE analyses. …”
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Enhancing environmental models with a new downscaling method for global radiation in complex terrain by A. Druel, J. Ruffault, H. Davi, A. Chanzy, O. Marloie, M. De Cáceres, A. Olioso, F. Mouillot, C. François, K. Soudani, N. K. Martin-StPaul

“…While radiation is highly variable at a fine spatial resolution in complex terrain due to shadowing effects, the data required for PBMs that are currently available over large extents are generally at a spatial resolution coarser than <span class="inline-formula">∼9</span> km. …”
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Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C by Masanori Sato, Koji Miyanishi, Shingo Tanaka, Akira Sakurada, Hiroki Sakamoto, Yutaka Kawano, Kohichi Takada, Masayoshi Kobune, Junji Kato

“…Hepatic iron accumulation is generally increased in the chronic hepatitis C (CHC) liver; however, the precise mechanism of such accumulation remains unclear. …”
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Validity of a smartphone application for self-monitoring psychiatric symptoms in patients with schizophrenia by Sung-Wan Kim, Jae-Kyeong Kim, Min Jhon, Ju-Wan Kim, Seunghyong Ryu, Ju-Yeon Lee, Jae-Min Kim

“…Concurrent validity was determined by correlating app-based ratings with established self-report and clinician-administered scales, including the Eppendorf Schizophrenia Inventory, Hamilton Program for Schizophrenia Voices Questionnaire, Beck Depression Inventory, Generalized Anxiety Disorder-7, and Perceived Stress Scale. …”
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Computational design of potent dimeric phenylthiazole NS5A inhibitors for hepatitis C virus by Wissal Liman, Mehdi Oubahmane, Nouhaila Ait Lahcen, Ismail Hdoufane, Driss Cherqaoui, Rachid Daoud, Achraf El Allali

“…Additionally, molecular mechanics generalized born surface area calculations were carried out to estimate the binding free energies of the inhibitor candidates, providing additional insights into their binding affinities and stabilities. …”
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Progression and mortality of patients with cystic fibrosis in China by Wangji Zhou, Yaqi Wang, Yanli Yang, Yanyan Sun, Chongsheng Cheng, Jinrong Dai, Shuzhen Meng, Keqi Chen, Yang Zhao, Xueqi Liu, Dingding Zhang, Song Liu, Weiguo Zhu, Yaping Liu, Kai-Feng Xu, Xinlun Tian

“…According to the mixed-effects model, for patients ≤ 30 years of age at diagnosis, FEV1% predicted decreased 1.17% per year. The generalized linear regression model showed that higher baseline FEV1% predicted and occurrence of pulmonary exacerbations were associated with the progression of patients with CF. …”
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Machine Learning Based Modeling of Thermospheric Mass Density by Qian Pan, Chao Xiong, Hermann Lühr, Artem Smirnov, Yuyang Huang, Chunyu Xu, Xu Yang, Yunliang Zhou, Yang Hu

“…Earlier empirical models based on multivariate least‐square‐fitting approach failed to achieve this good altitude generalization (e.g., Liu et al., 2013, https://doi.org/10.1002/jgra.50144; Xiong et al., 2018a, https://doi.org/10.5194/angeo‐2018‐25). …”
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Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis by Ailing Yu, Ailing Yu, Ailing Yu, Ailing Yu, Ailing Yu, Zian Bai, Zian Bai, Zian Bai, Zian Bai, Yijie Wang, Yijie Wang, Yijie Wang, Yijie Wang, Zhen Luo, Zhen Luo, Zhen Luo, Zhen Luo, Xiaochen Du, Mengxin Chen, Shuang Wen, Honglong Wang, Xiaoying Yuan, Chunyu Yang, Shanshan Bai, Bo Fan, Bo Fan, Bo Fan, Bo Fan

“…Subgroup analyses indicated that the preventive effect of finasteride in BCa incidence were generally consistent, regardless of study region, types of research. …”
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Association between Stigma and Pain in Patients with Temporomandibular Disorders by Rui Zhu, Li Zhang, Yun-Hao Zheng, Zi-Han Zhang, Li-Ming Zhang, Hao-Lun Yang, Yuan Yue, Xin Xiong

“…Two hundred and twenty-five patients with TMDs were recruited, and they completed the questionnaires including the Visual Analogue Scale of Pain (VAS), Generalized Anxiety Disorder 7-Item (GAD-7), the Patient Health Questionnaire 9-item (PHQ-9), Jaw Functional Limitation Scale 8-item (JFLS-8), the Stigma Scale for Chronic Illness 8-item (SSCI-8), and other demographic and disease-related information. …”
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Empowering nurse leaders: readiness for AI integration and the perceived benefits of predictive analytics by Mohamed Hashem Kotp, Hossam Ali Ismail, Hassan Ahmed Awad Basyouny, Mohamed Ahmed Aly, Abdelaziz Hendy, Abdulqadir J. Nashwan, Ahmed Hendy, Aliaa Ezz Eldin Abd Elmoaty

“…Conclusion The findings suggest that nursing leaders are generally prepared to integrate AI into their workflows, especially those with advanced education and experience. …”
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The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality by Tian-Qi Teng, Jing Liu, Meng-Meng Wang, De-Gang Mo, Rui Chen, Jia-Chao Xu, Zi-Han Dong, Ning Zhang, Hai-Chu Yu

“…A nomogram predicting survival rates based on sexual frequency achieved ROC areas of 0.782, 0.807, and 0.803 for 3, 5, and 10 years, with a calibration curve matching the ideal generally. Sexual frequency was associated with the incidence of CVD and all-cause mortality among young and middle-aged adults. …”
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Quality, topics, and demographic trends of animal systematic reviews - an umbrella review by Bernard Friedrich Hild, David Brüschweiler, Sophia Theodora Katharina Hild, Julia Bugajska, Viktor von Wyl, Marianna Rosso, Kimberley Elaine Wever, Eva Furrer, Benjamin Victor Ineichen

“…Reviews with a pre-registered protocol generally scored higher in quality. No significant differences in quality were observed between countries. …”
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Training Specialists in the Field of Innovative Financial Technologies in Russia by A. A. Tsyganov, S. V. Brovchak, Yu. A. Gorelova, L. S. Krutova

“…The authors applied generalization and empirical research methods such as selective market research, statistical observation. …”
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Antioxidant Activity of Extracts of Soursop (Annona muricata L.) Leaves, Fruit Pulps, Peels, and Seeds by Hakime Hülya Orak, Ilayda Sevik Bahrisefit, Temine Sabudak

“…MeOH and EtOAc extracts were rich sources of flavonoids. Generally, soursop leaf and fruit pulp extracts had the highest and the lowest both TPC and TFC, respectively. …”
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Two-Dimensional Electroosmotic Consolidation Theory of Nonlinear Soil Voltage Distribution Characteristics by Yang Shen, Jianting Feng, Yinghao Ma, Hanlong Liu

“…Soil voltage is generally assumed to show a linear relationship with distance from the cathode according to the established electroosmotic consolidation equation. …”
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