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Gene therapy by hepatocyte growth factor results in regression of experimental liver fibrosis
Published 2010-08-01“…Obtained results allow to consider gene therapy by hepatocyte growth factor in composition of non-viral vectors as one of perspective methods of treatment of chronic liver diseases.…”
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The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia
Published 2011-01-01“…The major breakthrough in β-thalassemia gene therapy occurred a decade ago with the development of globin LVs. …”
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Gene Therapy: A step toward advanced orthodontics – A narrative review
Published 2023-07-01Subjects: Get full text
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Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations
Published 2025-03-01Subjects: Get full text
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Current views on etiology, diagnosis, epidemiology and gene therapy of maturity onset diabetes in the young
Published 2025-01-01Subjects: Get full text
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Antigen-Specific Gene Therapy after Immunisation Reduces the Severity of Collagen-Induced Arthritis
Published 2013-01-01“…Thus, antigen-specific gene therapy is effective when administered throughout the inflammatory course of arthritis and offers a good model for investigation of the basic mechanisms during tolerance in CIA.…”
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Ensuring patient access to gene therapies for rare diseases: Navigating reimbursement and coverage challenges
Published 2025-03-01“…It emphasizes the need to account for the broader value of gene therapies, incorporate input from disease-specific clinical experts in payer coverage decisions, and reduce administrative barriers to coverage. …”
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The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy
Published 2021-06-01“…In this review, we discuss the role of EVs and their miRNA content in GB progression and resistance to therapy, with emphasis on their potential as diagnostic, prognostic and disease monitoring biomarkers and as nanocarriers for gene therapy.…”
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HMGB1 Box A gene therapy to alleviate bleomycin-induced pulmonary fibrosis in rats
Published 2025-01-01“…Previously, a new gene therapy technology using Box A of the HMGB1 plasmid (Box A) was used to reverse cellular senescence and cure liver fibrosis in aged rats. …”
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Oral Tolerance: A New Tool for the Treatment of Gastrointestinal Inflammatory Disorders and Liver-Directed Gene Therapy
Published 1999-01-01“…The use of oral tolerance toward adenoviruses and colitis-extracted proteins for long term gene therapy and alleviation of experimental colitis, and the mechanisms of tolerance induction are presented. …”
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Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure
Published 2025-02-01Subjects: Get full text
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Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy
Published 2015-01-01“…In this mini review, we summarize current theories pertaining to the application of gene therapy for neovascular AMD and the potential benefits when used in conjunction with endogenous antiangiogenic proteins.…”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy
Published 2025-02-01“…To study the therapeutic effect of systemic expression of sPD-L1, we administered AAV8/shPD-L1 gene therapy in CIA mice via retro-orbital injection and found significant improvements in joint inflammation and paw swelling, exhibiting similar phenotypes to that in naïve mice. …”
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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial
Published 2025-01-01“…Highlights This was the first gene therapy clinical trial to be completed for Fabry disease. …”
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Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model
Published 2013-01-01“…The aim of the present study is to detect a combination method to utilize gene therapy for the treatment of Parkinson’s disease (PD). …”
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E-Selectin/AAV Gene Therapy Promotes Myogenesis and Skeletal Muscle Recovery in a Mouse Hindlimb Ischemia Model
Published 2023-01-01“…These results suggest a potential role for E-sel/AAV gene therapy as a nonsurgical adjunct in patients with life-limiting PAD.…”
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38
Mathematical modeling of glioma therapy using oncolytic viruses
Published 2013-03-01Subjects: “…cancer gene therapy…”
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39
Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells
Published 2025-02-01Subjects: Get full text
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40
Therapeutics in paediatric genetic diseases: current and future landscape
Published 2023-01-01Subjects: Get full text
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