Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis by Maryam Mukhtar, Andleeb Batool, Abdul Wajid, Iram Qayyum

“…The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D. …”
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Phenogenetics of cortical granule dynamics during zebrafish oocyte-to-embryo transition by Priscila García-Castro, Isabella Giambó-Falian, Ingrid Carvacho, Ricardo Fuentes

“…The study of how genetic variations lead to observable phenotypes (phenogenetics) during the oocyte-to-embryo transition, have identified several maternal-effect genes in zebrafish involved in CG behavior. These genes regulate various stages of CG biology, including biosynthesis, maturation, and exocytosis. …”
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TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton by Mona Elsafadi, Muthurangan Manikandan, Sami Almalki, Mohammad Mobarak, Muhammad Atteya, Zafar Iqbal, Jamil Amjad Hashmi, Sameerah Shaheen, Nehad Alajez, Musaad Alfayez, Moustapha Kassem, Raed Abu Dawud, Amer Mahmood

“…Global gene expression profiling revealed a significant enrichment of pathways related to osteogenesis and adipogenesis and of genes regulated by both TGFβ1 and cytochalasin D. Our study demonstrates that TGFβ1 enhances hMSC commitment to either the osteogenic or adipogenic lineages by reorganizing the actin cytoskeleton.…”
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Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation by Yong Zhao, Hao Wang, Ming Lu, Xin Qiao, Bei Sun, Weihui Zhang, Dongbo Xue

“…Specifically, the target genes regulated macrophage activation through the TRAF6-TAB2-TAK1-NIK/IKK-NFκB pathway. …”
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Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate by Jayalekshmi Haripriyan, Christy Rose Binu, Nitasha D Menon, Muralidharan Vanuopadath, Malavika B. Hari, N Namitha, Kesiya Binoy, Anil Kumar, Bipin G. Nair, Victor Nizet, Geetha B. Kumar

“…Additionally, downregulation of the expression of virulence genes regulated by quorum sensing (QS) and a decrease in levels of the QS signaling molecule, C12-HSL, were also observed. …”
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Gene Profiles in the Early Stage of Neuronal Differentiation of Mouse Bone Marrow Stromal Cells Induced by Basic Fibroblast Growth Factor by Lili Yu, Wei Hong, Haijie Yang, Yin Yan Xia, Zhiwei Feng

“…To identify the genes regulating neuronal differentiation, cDNA microarray analysis was conducted using mRNAs isolated from cells differentiated for different time periods (0, 4, 24, and 72 h) after bFGF treatment. …”
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Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions by Sha He, Haiyan Ou, Cunyou Zhao, Jian Zhang

“…Overall, our results demonstrate that SNPs in clustered miRNA seed regions can take part in more intricate and complex gene-regulating networks with lower functional cost by functional complementarity. …”
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Constipation at endocrine diseases by Yu. O. Shulpekova, A. G. Komova

“…Constipation is one of broad spectrum of gastro-intestinal hyperthyroidism manifestations, probably, related to change in expression of the genes regulating motility, decrease of autonomous nervous system excitability and dehydration. …”
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Cereal inflorescence: features of morphology, development and genetic regulation of morphogenesis by O. B. Dobrovolskaya, A. E. Dresvyannikova

“…The genes involved in the control of the cereal inflorescence development have been identified using mutants (mainly maize and rice) with altered inflorescence and floret morphology; most of these genes regulate the initiation and fate of meristems. The presence of some genetic mechanisms in cereals confirms the models previously discovered in dicotyledonous plants; on the other hand, there are cereal-specific developmental processes that are controlled by new modules of genetic regulation, in particular, associated with the formation of a branched inflorescence. …”
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Identification of KRT16 and ANXA10 as cell cycle regulation genes for lung adenocarcinoma based on self-transcriptome sequencing of surgical samples and TCGA public data mining by Wen-jian Liu, Jia-pan Shen, Ren-quan Zhang, Xiao-yun Fan

“…Conclusions KRT16 and ANXA10 are potential genes regulating the development of LUAD. Also, they may be potential targets for the targeted therapy of LUAD by inhibiting the proliferation of lung cancer cells and blocking the cell cycle by affecting key protein expression levels at cell cycle checkpoints.…”
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Genetics of aging and longevity by A. A. Moskalev, E. N. Proshkina, A. A. Belyi, I. A. Solovyev

“…Based on the analysis of geroprotective potential of examined genes’ regulation, main targets have been identified to slowdown aging and achieve healthy longevity. …”
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Using achievements of fruit crop genetics and breeding: a contribution from the Michurinsk Department of the Vavilov Society of Geneticists and Breeders by N. I. Savel’ev, N. N. Savel’eva

“…Some genes were identified for the first time. These are genes regulating Coccomyces hiemalis Higg. resistance (A), retarded growth habit in cherry (O2), astringency (Ta) and juiciness (Su) of fruit in pear. …”
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Reconstruction and analysis of the gene regulatory network for cell wall function in <i>Arabidopsis thaliana</i> L. leaves in response to water deficit by A. R. Volyanskaya, E. A. Antropova, U. S. Zubairova, P. S. Demenkov, A. S. Venzel, Y. L. Orlov, A. A. Makarova, T. V. Ivanisenko, T. A. Gorshkova, A. R. Aglyamova, N. A. Kolchanov, M. Chen, V. A.  Ivanisenko

“…The analysis of the gene network and the transcriptome data analysis allowed prioritizing transcription factors (TF) based on their enrichment of differentially expressed genes regulated by them. As a result, scores were calculated, acting as indicators of the association of TFs with water deficit. …”
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Cooperative mechanisms of LexA and HtpG in the regulation of virulence gene expression in Pseudomonas plecoglossicida by Rongchao He, Yanfei Zuo, Qiu Li, Qingpi Yan, Lixing Huang

“…Our findings identified 36 downstream virulence genes regulated by LexA, define three critical LexA binding motifs, and provide an in-depth analysis of LexA's recognition and binding to promoters, thereby regulating virulence gene expression. …”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…We utilized chromatin immunoprecipitation sequencing with H3K18la antibodies, transcriptomics of clinical BC samples, and proteomics and ATAC-seq analyses of in vivo tumors to identify the genes regulated by H3K18la and the transcription factor PPARD. qPCR and Western blot assays were used to detect expressions of molecules. …”
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Physiological and molecular mechanisms of exogenous salicylic acid in enhancing salt tolerance in tobacco seedlings by regulating antioxidant defence system and gene expression by Xiliang Song, Jian Chen, Can Xu, Xianjie Cai, Wenjing Song, Aixia Chang, Yu Zhang, Chenggang Luo

“…Exogenous SA also increased ascorbate and glutathione levels and reduced their reduced forms by increasing the activities of glutathione reductase, ascorbate peroxidase, monodehydroascorbate reductase and dehydroascorbate reductase. qRT−PCR analysis revealed that the key genes regulating SA biosynthesis, carbon assimilation, the antioxidant system and the ascorbate−glutathione cycle were activated by SA under conditions of salt stress.DiscussionOur study elucidates the physiological and molecular mechanisms of exogenous SA in enhancing plant salt tolerance and provides a practical basis for crop improvement in saline environments.…”
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Genes underlying cold acclimation in the tea plant (<i>Camellia sinensis</i> (L.) Kuntze) by L. S. Samarina, L. S. Malyukova, M. V. Gvasaliya, A. M. Efremov, V. I. Malyarovskaya, S. V. Loshkareva, M. T. Tuov

“…The results of the research emphasize the need to further explore the ways in which various genes regulate the tolerance of tea to cold stress to find the molecular markers of frost tolerance.…”
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Мutants of inflorescence development in alfalfa (Medicago sativa L.) by N. I. Dzyubenko, E. A. Dzyubenko

“…New data concerning genes regulating inflorescence development in model legumes approach us to understanding the phenomenon of inflorescence mutations in alfalfa. …”
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YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…MR analysis revealed that the EGFR gene regulated YAP1 expression. YAP1 was identified as a hub gene closely associated with immunosuppressive microenvironment and poor prognosis in EGFR-mutant NSCLC population in TCGA LUAD. …”
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Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres by Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

“…VPA increased H3K9 occupancy of the promoter region of <i>TP53</i>. Among the genes regulated by VPA, the stemness regulators <i>MYC</i> and <i>NES</i> showed an association with patient survival in specific MB subgroups. …”
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