Protein Profiling and Histone Deacetylation Activities in Somaclonal Variants of Oil Palm (Elaeis guineensis Jacq.) by Jamilah Syafawati Yaacob, Hwei-San Loh, Rosna Mat Taha

“…Histone deacetylases (HDACs), involved in eukaryotic gene regulation by catalyzing the acetyl groups are removal from lysine residues on histone, hence transcriptionally repress gene expression. …”
Get full text

Axon regeneration: an issue of translation by Schaeffer, Julia, Belin, Stephane

“…Conversely, the translation process (from mRNA to protein) provides an additional layer of gene regulation. This aspect has been overlooked in CNS regeneration. …”
Get full text

Multi-resource constrained elective surgical scheduling with Nash equilibrium toward smart hospitals by Jun Xue, Zhi Li, Shuangli Zhang

Get full text

Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection? by Terry S. Elton, Sarah E. Sansom, Mickey M. Martin

“…Since miRNA SNPs (miRSNPs) can create, destroy, or modify miRNA binding sites, this review focuses on the hypothesis that transcribed target SNPs harbored in RAS mRNAs, that alter miRNA gene regulation and consequently protein expression, may contribute to cardiovascular disease susceptibility.…”
Get full text

The role of chromatin state in intron retention: A case study in leveraging large scale deep learning models. by Ahmed Daoud, Asa Ben-Hur

“…We argue that these models are the equivalent of foundation models in natural language processing in their utility, as they encode within them chromatin state in its different aspects, providing useful representations that allow quick deployment of accurate models of gene regulation. We demonstrate this premise by leveraging the recently created Sei model to develop simple, interpretable models of intron retention, and demonstrate their advantage over models based on the DNA language model DNABERT-2. …”
Get full text

Functions and applications of RNA interference and small regulatory RNAs by Feng Xuezhu, Guang Shouhong

“…Small regulatory RNAs play a variety of crucial roles in eukaryotes, influencing gene regulation, developmental timing, antiviral defense, and genome integrity via a process termed RNA interference (RNAi). …”
Get full text

Comparisons between Arabidopsis thaliana and Drosophila melanogaster in relation to Coding and Noncoding Sequence Length and Gene Expression by Rachel Caldwell, Yan-Xia Lin, Ren Zhang

“…In conclusion, the information described in this study provides the basis for further exploration into gene regulation with regard to coding and noncoding sequence length.…”
Get full text

Biological Effects of Culture Substrates on Human Pluripotent Stem Cells by Yohei Hayashi, Miho Kusuda Furue

Get full text

Exploring Multiplex Immunohistochemistry (mIHC) Techniques and Histopathology Image Analysis: Current Practice and Potential for Clinical Incorporation by Aria Kaiyuan Sun, Song Fan, Siu Wai Choi

Get full text

Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases by Francisco A. Monsalve, Radha D. Pyarasani, Fernando Delgado-Lopez, Rodrigo Moore-Carrasco

“…This review mainly focuses on the biological role of PPARs in gene regulation and metabolic diseases, with particular focus on the therapeutic potential of PPAR modulators in the treatment of thrombosis.…”
Get full text

ChromatinHD connects single-cell DNA accessibility and conformation to gene expression through scale-adaptive machine learning by Wouter Saelens, Olga Pushkarev, Bart Deplancke

“…Abstract Gene regulation is inherently multiscale, but scale-adaptive machine learning methods that fully exploit this property in single-nucleus accessibility data are still lacking. …”
Get full text

PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways by Yves Lecarpentier, Victor Claes, Jean-Louis Hébert

“…Peroxisome proliferator-activated receptors (PPAR α, β/δ and γ) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. …”
Get full text

Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

Get full text

Detection by Single-Cell RNA Sequencing of Virally Mediated Skin Diseases by Linda Zhou, Thomas H. Leung

“…Combining single-cell RNA-sequencing data with virome detection strategies represents a potentially powerful approach to investigate and elucidate virus-mediated gene regulation in health and disease.…”
Get full text

The study of the regulatory region of the Drosophila melanogaster Notch gene by new methods of directed genome editing by O. V. Andreyenkov, E. I. Volkova, N. G. Andreyenkova, S. A. Demakov

“…Thus, it provided a new powerful tool for studies of Notch gene regulation and the organization of the open chromatin state.…”
Get full text

Conventional and High-Speed Intravital Multiphoton Laser Scanning Microscopy of Microvasculature, Lymphatics, and Leukocyte-Endothelial Interactions by Timothy P. Padera, Brian R. Stoll, Peter T.C. So, Rakesh K. Jain

“…Intravital imaging of gene regulation and the physiological effect of the gene products can play a powerful role in this pursuit. …”
Get full text

Intake of S-Methylmethionine Alters Glucose Metabolism and Hepatic Gene Expression in C57BL/6J High-Fat-Fed Mice by Mariana Buranelo Egea, Gavin Pierce, Neil Shay

“…Liver triglycerides and MCP-1 levels showed no significant differences between fed groups. By the positive gene regulation of <i>Sult1e1</i>, <i>Phlda1</i>, and <i>Ciart</i>, we hypothesized that SMM administration to mice may have regulated xenobiotic, glucose, and circadian rhythm pathways.…”
Get full text

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding by Duyen Huynh, Philipp Hoffmeister, Tobias Friedrich, Kefan Zhang, Marek Bartkuhn, Francesca Ferrante, Benedetto Daniele Giaimo, Rhett A. Kovall, Tilman Borggrefe, Franz Oswald, J. Christof M. Gebhardt

“…How TF-DNA binding kinetics and cofactor interactions modulate gene regulation is mostly unknown. We determine the binding kinetics, transcriptional activity, and genome-wide chromatin occupation of RBPJ and mutant variants by live-cell single-molecule tracking, reporter assays, and ChIP-Seq. …”
Get full text

Advances on relationship between phthalate exposure and perinatal depression by Yueming XU, Mei ZHAO, Yichao HUANG, Lingling YU, Lan GENG, Lei CHEN

“…It also summarized the potential roles of hormone-neurotransmitter pathway, inflammation mediation, gene regulation, and other possible mechanisms in the association between exposure to PAEs and perinatal depression. …”
Get full text

LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling by Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, Ruiqin Xie

“…Long non-coding RNAs (lncRNAs) play many important roles in gene regulation and disease pathogenesis. Here, we sought to determine that mitochondrial dynamic related lncRNA (MDRL) modulates NLRP3 inflammasome activation and apoptosis of vascular smooth muscle cells (VSMCs) and protects arteries against atherosclerosis. …”
Get full text