Virulence Factors of Clostridioides (Clostridium) difficile Linked to Recurrent Infections by Laura Tijerina-Rodríguez, Licet Villarreal-Treviño, Rayo Morfín-Otero, Adrián Camacho-Ortíz, E. Garza-González

“…Additional factors have shown to regulate toxin production and virulence in C. difficile in RCDI, including the accessory-gene regulator agr, which acts as a positive switch for toxin transcription. …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Objective‍　‍To map the genome-wide distribution profile of histone H3K27me3 modification in diffuse gastric cancer tissues， identify target genes regulated by H3K27me3， and primarily explore the potential mechanism of its modification reprogramming in the occurrence and development of the tumor. …”
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The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR by Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner

“…This in-depth analysis of a prokaryotic gene regulator reveals a landscape that is navigable but much more rugged than the landscapes of eukaryotic regulators.…”
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Effect of Chronic Valproic Acid Treatment on Hepatic Gene Expression Profile in Wfs1 Knockout Mouse by Marite Punapart, Mall Eltermaa, Julia Oflijan, Silva Sütt, Anne Must, Sulev Kõks, Leonard C. Schalkwyk, Catherine Fernandes, Eero Vasar, Ursel Soomets, Anton Terasmaa

“…We identified 42 genes affected by Wfs1 genotype, 10 genes regulated by VPA treatment, and 9 genes whose regulation by VPA was dependent on genotype. …”
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Novel transcripts of EMT driving the malignant transformation of oral submucous fibrosis by Smitha Sammith Shetty, Kanaka Sai Ram Padam, Mohit Sharma, Adarsh Kudva, Pratik Patel, Raghu Radhakrishnan

“…We aimed to identify and validate novel genes associated with the regulation of epithelial-to-mesenchymal transition (EMT) in OSF. Genes regulating EMT were identified through differential gene expression analysis, using a LogFC threshold of -1 and + 1 and a padj value < 0.05, based on data from GEO datasets and the TCGA-HNSC datasets. …”
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LINC01614 Promotes Colorectal Cancer Cell Growth and Migration by Regulating miR-217-5p/HMGA1 Axis by Jiwei Jia, Pei Guo, Li Zhang, Wenqing Kong, Fangfang Wang

“…Recently, a long non-coding RNA (lncRNA), LINC01614, has emerged as a vital gene regulator in cancer progression. Yet, how LINC01614 affects CRC progression remains enigmatic. …”
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INNA N. GOLUBOVSKAYA AS THE FOUNDER OF A UNIQUE COLLECTION OF MEIOTIC GENE MUTATIONS IN MAIZE AND A TALENTED RESEARCHER OF THE PROBLEM OF MEIOSIS GENETIC CONTROL by Yu. F. Bogdanov

“…She was actively involved in cloning and studying major genes regulating meiosis in maize at the molecular level, and their expression in meiotic process. …”
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Sonic hedgehog and fibroblast growth factor 8 regulate the evolution of amniote facial proportions by Marta Marchini, Greta Keller, Naaz Khan, Rushabh Shah, Adriana Saliceti Galarza, Katherine B. Starr, Alexandra Apostopoulos, Thomas J. Sanger

“…By investigating facial morphogenesis in the lizard, Anolis sagrei, we show that reptilian skull development is driven by the same genes as mammals and birds, but the manner in which those genes regulate facial development is clade-specific. These genes are not expressed in the frontal-nasal prominence, the region of the avian FEZ. …”
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Co-targeting of glial activation and inflammation by tsRNA-Gln-i-0095 for treating retinal ischemic pathologies by Ying Zhang, Yan Ma, Yu-Ke Ji, Yi-Fei Jiang, Duo Li, Wan Mu, Mu-Di Yao, Jin Yao, Biao Yan

“…Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are emerging as novel gene regulators, involved in various biological processes and human diseases. …”
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Transformation of brain myeloid cell populations by SIV in rhesus macaques revealed by multiomics by Xiaoke Xu, Meng Niu, Benjamin G. Lamberty, Katy Emanuel, Moses Jedd Facun Apostol, Howard S. Fox

“…Additionally, we observe a dramatic shift of upstream gene regulators and their targets in brain myeloid cells during SIVE. …”
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Network analysis uncovers the master role of WRKY transcription factors in Arabidopsis thaliana response to N-acyl homoserine lactones by Yongming Duan, Min Han, Maja Grimm, Adam Schikora

“…We identified several key genes regulated in plants exposed to multiple AHL molecules. …”
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Disruption of Energy Metabolism and Reactive Oxygen Species Homeostasis in Honglian Type-Cytoplasmic Male Sterility (HL-CMS) Rice Pollen by Wang Mingyue, Zhao Weibo, Feng Xiaoya, Chen Yi, Li Junhao, Fu Jinmei, Yan Yingchun, Chu Zhaohui, Huang Wenchao

“…However, the mechanisms by which sterility genes regulate metabolic alterations and changes in mitochondrial morphology in the pollen of HL-CMS remain unclear. …”
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Function of vasohibin-2 and the mechanism of alternative splicing in triple-negative breast cancer by WANG Wei, WANG Hongli, ALIBIYATI·i Ain, YILIYAER· Rousu, NUER AYI, YANG Liang

“…Differentially expressed genes and alternatively spliced genes regulated by VASH2 were analyzed to explore the mechanism of action of VASH2 in TNBC.Results·VASH2 was significantly overexpressed in TNBC compared to the normal tissues. …”
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Phenogenetics of cortical granule dynamics during zebrafish oocyte-to-embryo transition by Priscila García-Castro, Isabella Giambó-Falian, Ingrid Carvacho, Ricardo Fuentes

“…The study of how genetic variations lead to observable phenotypes (phenogenetics) during the oocyte-to-embryo transition, have identified several maternal-effect genes in zebrafish involved in CG behavior. These genes regulate various stages of CG biology, including biosynthesis, maturation, and exocytosis. …”
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TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton by Mona Elsafadi, Muthurangan Manikandan, Sami Almalki, Mohammad Mobarak, Muhammad Atteya, Zafar Iqbal, Jamil Amjad Hashmi, Sameerah Shaheen, Nehad Alajez, Musaad Alfayez, Moustapha Kassem, Raed Abu Dawud, Amer Mahmood

“…Global gene expression profiling revealed a significant enrichment of pathways related to osteogenesis and adipogenesis and of genes regulated by both TGFβ1 and cytochalasin D. Our study demonstrates that TGFβ1 enhances hMSC commitment to either the osteogenic or adipogenic lineages by reorganizing the actin cytoskeleton.…”
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Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation by Yong Zhao, Hao Wang, Ming Lu, Xin Qiao, Bei Sun, Weihui Zhang, Dongbo Xue

“…Specifically, the target genes regulated macrophage activation through the TRAF6-TAB2-TAK1-NIK/IKK-NFκB pathway. …”
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Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate by Jayalekshmi Haripriyan, Christy Rose Binu, Nitasha D Menon, Muralidharan Vanuopadath, Malavika B. Hari, N Namitha, Kesiya Binoy, Anil Kumar, Bipin G. Nair, Victor Nizet, Geetha B. Kumar

“…Additionally, downregulation of the expression of virulence genes regulated by quorum sensing (QS) and a decrease in levels of the QS signaling molecule, C12-HSL, were also observed. …”
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Gene Profiles in the Early Stage of Neuronal Differentiation of Mouse Bone Marrow Stromal Cells Induced by Basic Fibroblast Growth Factor by Lili Yu, Wei Hong, Haijie Yang, Yin Yan Xia, Zhiwei Feng

“…To identify the genes regulating neuronal differentiation, cDNA microarray analysis was conducted using mRNAs isolated from cells differentiated for different time periods (0, 4, 24, and 72 h) after bFGF treatment. …”
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Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions by Sha He, Haiyan Ou, Cunyou Zhao, Jian Zhang

“…Overall, our results demonstrate that SNPs in clustered miRNA seed regions can take part in more intricate and complex gene-regulating networks with lower functional cost by functional complementarity. …”
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Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct by Wattanapitayakul Suvara K., Chularojmontri Linda, Schäfer-Korting Monika

“…Senescence induced by high dose UVB resulted in morphological changes, enhanced β-gal activity, elevated cellular ROS levels and reduced DNA synthesis. qPCR revealed differential expression of the genes regulated senescence. p16INK4a expression was significantly increased in NHK exposed to UVB whereas enhanced IFI27 expression was observed only in cultural senescence. …”
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