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1741
Orthoweb: a software package for evolutionary analysis of gene networks
Published 2025-01-01“…These indices are important for understanding the dynamics of gene expression and its impact on the development and adaptation of organisms. …”
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1742
Periductal Mastitis: An Inflammatory Disease Related to Bacterial Infection and Consequent Immune Responses?
Published 2017-01-01“…With 16S rRNA gene sequencing, we confirmed bacterial infections were found in all PDM patients, but none of the control patients was positive on the gene expression of 16S rRNA. Our results also demonstrated significant increases of the IFN-γ and IL-12A expression in PDM, but there was no difference in IL-17A expression in these two groups. …”
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1743
Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications
Published 2025-01-01“…Through transcriptomic and single-cell RNA sequencing analyses, we explored metabolic pathway enrichment, immune infiltration patterns, and differential gene expression in prostate cancer samples. The results showed that pyrimidine metabolism-related genes were significantly upregulated in the P2 subgroup compared to the P1 subgroup, with enhanced metabolic activity observed in basal and luminal epithelial cells. …”
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1744
Negative Effects of High Glucose Exposure in Human Gonadotropin-Releasing Hormone Neurons
Published 2013-01-01“…In this study, we investigated the high glucose effects in the human GnRH-secreting FNC-B4 cells. Gene expression profiling by qRT-PCR, confirmed that FNC-B4 cells express GnRH and several genes relevant for GnRH neuron function (KISS1R, KISS1, sex steroid and leptin receptors, FGFR1, neuropilin 2, and semaphorins), along with glucose transporters (GLUT1, GLUT3, and GLUT4). …”
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1745
Analysis of expression and transport activity of sugar transporter gene HpSWEET7 from red pitaya
Published 2025-01-01“…[Methods] HpSWEET7 gene was isolated from ‘Zihonglong’, and sequence alignment and phylogenetic relationship were analyzed. Gene expression was analyzed by qRT-PCR, and the subcellular localization was detected by fusing fluorescent protein. …”
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1746
MicroRNAs in the DNA Damage/Repair Network and Cancer
Published 2014-01-01“…MicroRNAs are endogenous short noncoding molecules able to regulate gene expression at the post-transcriptional level. Due to their activity, microRNAs play a role in many fundamental physiological and pathological processes. …”
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1747
Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease
Published 2012-01-01“…Data generated by microarray analysis of gene expression suggested that galectin-3 deficiency causes alterations in the expression of various genes associated with carcinogenesis and lipid metabolism. …”
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1748
Genome-wide identification of HbVQ proteins and their interaction with HbWRKY14 to regulate the expression of HbSRPP in Hevea brasiliensis
Published 2025-01-01“…Gene structure analysis revealed that most of HbVQs had no introns except for HbVQ5 and HbVQ20. Gene expression analysis revealed that HbVQ4, 5, and 21 were expressed at relatively high levels in latex. …”
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1749
5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity
Published 2014-01-01“…T-cells from healthy donors were treated with 5-Aza and analyzed by qRT-PCR and flow cytometry for changes in gene expression and phenotype. Functionality was assessed by a tumor lysis assay. …”
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1750
A Narrative Review of Prognostic Gene Signatures in Oral Squamous Cell Carcinoma Using LASSO Cox Regression
Published 2025-01-01“…As the Cancer Genome Atlas (TCGA) dataset is available in HNSCC, the survival analysis prognosis of OSCC patients based on the TCGA dataset for discovering gene expression-based prognostic biomarkers is limited. …”
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1751
Androgen Receptor-Target Genes in African American Prostate Cancer Disparities
Published 2013-01-01“…To elucidate the molecular mechanisms underlying PCa disparities, we employed an integrative approach combining gene expression profiling and pathway and promoter analyses to investigate differential transcriptomes and deregulated signaling pathways in AA versus CA cancers. …”
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1752
Role of CXCL10 released from osteocytes in response to TNF-α stimulation on osteoclasts
Published 2025-01-01“…RNA sequencing (RNA-seq) revealed that TNF-α stimulation increased C-X-C motif chemokine ligand 10 (CXCL10) gene expression in osteocytes. Although CXCL10 did not affect osteoclast differentiation in vitro, it enhanced the migration of osteoclast precursors. …”
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1753
Pantoprazole Decreases Cell Viability and Function of Human Osteoclasts In Vitro
Published 2015-01-01“…Osteoclast-specific gene expression was evaluated after seven days and revealed no significant differences between all samples. …”
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1754
STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease
Published 2019-01-01“…Signal transducer and activator of transcription 3 (STAT3) regulates gene expression in a cell-specific, cytokine-dependent manner, involving multiple immune responses. …”
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1755
A systematic screening assay identifies efficient small guide RNAs for CRISPR activation
Published 2025-01-01“…The most efficient sgRNAs also demonstrated activation of endogenous gene expression at mRNA level. Correlation analysis of gene activation relative to sgRNA binding site distance to transcription start-site or nearby transcription factor binding sites failed to detect common characteristics influencing gene activation in the selected promoter regions. …”
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1756
Expression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia
Published 2025-01-01“…There was no significant difference in CTNNB1 gene expression in the medicated patients compared to controls (P value = 0.9754). …”
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1757
Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies
Published 2025-02-01“…MicroRNAs (miRNAs) and the gut microbiome are key regulators of human health, with emerging evidence highlighting their complex, bidirectional interactions in chronic diseases. miRNAs, influence gene expression and can modulate the composition and function of the gut microbiome, impacting metabolic and immune processes. …”
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1758
Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment
Published 2019-01-01“…Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates gene expression through poly(ADP)-ribosylation, resulting in the loosening of chromatin structure. …”
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1759
Transcriptomic analysis of the root system of Platycodon grandiflorum in response to the fallen leaves of Acer truncatum
Published 2024-12-01“…[Methods] We performed transcriptome sequencing using Illumina high throughput sequencing technology. Gene expression changes in the synthesis pathways of terpenes, flavonoids, and phenylpropanoid secondary metabolites were analyzed. …”
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1760
Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis
Published 2021-01-01“…The transcriptional expression profiles of GSDMB in ccRCC tissues in addition to normal tissues were retrieved from The Cancer Genome Atlas (TCGA) and additionally verified in a different independent cohort, which was obtained from the Gene Expression Omnibus (GEO) database. The Human Protein Atlas and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) were used to assess the protein expression of GSDMB. …”
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