Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells by Patrícia S. de Araújo-Souza, Steffi C. H. Hanschke, João P. B. Viola

“…However, naïve CD8 T lymphocytes do not produce large amounts of IFN-γ, but after TCR stimulation there is a progressive acquisition of IFN-γ expression during differentiation into cytotoxic T lymphocytes (CTL) and memory cells, which are capable of producing high levels of this cytokine. Differential gene expression can be regulated from the selective action of transcriptional factors and also from epigenetic mechanisms, such as DNA CpG methylation or posttranslational histone modifications. …”
Get full text

Absence of Rybp Compromises Neural Differentiation of Embryonic Stem Cells by Gergo Kovacs, Viktoria Szabo, Melinda K. Pirity

“…Furthermore, lack of rybp coincided with altered gene expression of key neural markers including Pax6 and Plagl1 pinpointing a possible transcriptional circuit among these genes.…”
Get full text

The Role of MicroRNAs in Cardiac Stem Cells by Nima Purvis, Andrew Bahn, Rajesh Katare

“…MicroRNAs (miRs) are small, noncoding RNA molecules that regulate gene expression at the posttranscriptional level. Recent studies have demonstrated the important role of miRs in regulating stem cell proliferation and differentiation, as well as other physiological and pathological processes related to stem cell function. …”
Get full text

Pituitary adenoma: important genetic factors and clinical diagnostic issues by G. Juknytė, E. Karinauskė, R. Liutkevičienė

“…Analysis of mRNA expression is also performed to assess the decrease or increase in gene expression in the case of pathology. All of these studies are aimed at finding new molecular markers for the development of targets for the treatment of pituitary adenomas. …”
Get full text

Neuronal heterogeneity in the ventral tegmental area: Distinct contributions to reward circuitry and motivated behavior by N. Dalton Fitzgerald, Jeremy J. Day

“…Distinct subtypes of DA neurons can be identified across the VTA and substantia nigra pars compacta (SNc) by characteristics that include gene expression patterns (molecular identity), connectivity motifs (network identity), and patterns of task-linked activity and neurotransmitter release (computational identity). …”
Get full text

Harnessing amino acid pathways to influence myeloid cell function in tumor immunity by Jiongli Pan, Yi Lin, Xinyuan Liu, Xiaozhen Zhang, Tingbo Liang, Xueli Bai

“…Abstract Amino acids are pivotal regulators of immune cell metabolism, signaling pathways, and gene expression. In myeloid cells, these processes underlie their functional plasticity, enabling shifts between pro-inflammatory, anti-inflammatory, pro-tumor, and anti-tumor activities. …”
Get full text

PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis by Lina Sabatino, Alessandra Fucci, Massimo Pancione, Vittorio Colantuoni

“…These studies have highlighted how epigenetic modifications influence PPARG gene expression in colorectal tumorigenesis. In this paper, we take a comprehensive look at the current understanding of the relationship between PPARγ and cancer development. …”
Get full text

Induction of systemic resistance through calcium signaling in Arabidopsis exposed to air plasma-generated dinitrogen pentoxide. by Shota Sasaki, Hiroto Iwamoto, Keisuke Takashima, Masatsugu Toyota, Atsushi Higashitani, Toshiro Kaneko

“…In addition, jasmonic acid (JA)-related gene expression was induced within 10 minutes, and a significant upregulation of the defense-related gene PDF1.2 was observed after 1 day of exposure to N2O5 gas. …”
Get full text

Development and functional evaluation of a psoralen-conjugated nucleoside mimic for triplex-forming oligonucleotides by Yu Mikame, Haruki Toyama, Chikara Dohno, Takehiko Wada, Asako Yamayoshi

“…Abstract Psoralen-conjugated triplex-forming oligonucleotides (Ps-TFOs) have been employed for the photodynamic regulation of gene expression by the photo-cross-linking of psoralen with the target DNA. …”
Get full text

Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos by Fabio Morato Monteiro, Clara Slade Oliveira, Letícia Zoccolaro Oliveira, Naiara Zoccal Saraiva, Maria Eugênia Zerlotti Mercadante, Flavia Lombardi Lopes, Daniel Robert Arnold, Joaquim Mansano Garcia

“…The low efficiency observed in cloning by nuclear transfer is related to an aberrant gene expression following errors in epigenetic reprogramming. …”
Get full text

Disorders in brassinosteroids signal transduction triggers the profound molecular alterations in the crown tissue of barley under drought. by Anetta Kuczyńska, Martyna Michałek, Piotr Ogrodowicz, Michał Kempa, Paweł Krajewski, Vladimiro Cardenia, Maria Teresa Rodriguez-Estrada, Marina Pérez-Llorca, Sergi Munné-Bosch, Krzysztof Mikołajczak

“…On the other hand, a set of genes expressed independently of the genotype was identified, including dehydrin encoding genes. …”
Get full text

Clocking In Time to Gate Memory Processes: The Circadian Clock Is Part of the Ins and Outs of Memory by Oliver Rawashdeh, Rex Parsons, Erik Maronde

“…In mammals, long-term memory (LTM) formation is tightly coupled to de novo gene expression of plasticity-related proteins and posttranslational modifications and relies on intact cAMP/protein kinase A (PKA)/protein kinase C (PKC)/mitogen-activated protein kinase (MAPK)/cyclic adenosine monophosphate response element-binding protein (CREB) signaling. …”
Get full text

Knockdown MTDH Inhibits Glioma Proliferation and Migration and Promotes Apoptosis by Downregulating MYBL2 by Junqi Fu, Jun Peng, Guolong Tu

“…GEPIA was employed to find the difference of the expression level of MTDH and MYB protooncogene-like 2 (MYBL2) in glioma tissues and normal tissues, and real-time quantitative reverse transcription PCR (qRT-PCR) and western blot (WB) were applied to verify the differential gene expression of MTDH and MYBL2 cells. After knocking down of MTDH, the expressions of forkhead box M1 (FoxM1), MTDH, and MYBL2 were detected by WB cells. …”
Get full text

TLR10 overexpression modulates immune response in A549 lung epithelial cells challenged with SARS-CoV-2 S and N proteins by Špela Knez, Mojca Narat, Jernej Ogorevc

“…The results showed that overexpression of TLR10 in A549 lung epithelial cells, immunostimulated with SARS-CoV-2 proteins S and N mainly downregulated proinflammatory cytokines and interferons and affected gene expression in the cocultured THP-1 monocytes. Our results suggest that TLR10 could mediate the extent of SARS-CoV-2 infection by downregulating the release of inflammatory cytokines and chemokines such as CXCL10, IL6, IL8, and IFNβ. …”
Get full text

Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver by Youzan Ferdiand Djohan, Massara Camara-Cissé, Gilles Fouret, Béatrice Bonafos, Bernard Jover, Jean-Paul Cristol, Charles Coudray, Christine Feillet-Coudray, Eric Badia

“…We found that diets rich in olive oil, palm oil, or lard altered mitochondrial biogenesis by significantly decreasing Pgc1α gene expression and altered the fatty acid composition of rat liver mitochondrial membrane PL.…”
Get full text

Flavonoids-rich extract of Aframomum melegueta (black pepper) improves antioxidant status and modulates aging process in lead-induced neurotoxic Drosophila melanogaster by Mohammed Sani Jaafaru

“…The extract also hindered the detrimental effects of Pb by increasing the activities and gene expression levels of catalase and superoxide dismutase with concurrent inhibition of AChE activity and expression in the toxic environment. …”
Get full text

Interactions between key genes and pathways in prostate cancer progression and therapy resistance by Fan Wu, Hengsen Zhang, Miaomiao Hao

“…Prostate cancer development is a complex, multigenic, and multistep process that involves numerous gene mutations, alteration in gene expression, and changes in signaling pathways. Key genetic and pathway alterations include the amplification and/or mutation of the androgen receptor, the loss of Rb, PTEN, and p53, the activation of the WNT signaling pathway, and the amplification of the MYC oncogene. …”
Get full text

Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes by Paweł Karpiński, Łukasz Łaczmański, Maria M. Sąsiadek

“…However, deregulation of major histocompatibility complex (MHC) gene expression is poorly characterized in the context of molecular cancer subtypes. …”
Get full text

Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection? by Terry S. Elton, Sarah E. Sansom, Mickey M. Martin

“…MicroRNAs (miRNAs) are a family of small, ∼21-nucleotide long, and nonprotein-coding RNAs that recognize target mRNAs through partial complementary elements in the 3-untranslated region (3-UTR) of mRNAs and inhibit gene expression by targeting mRNAs for translational repression or destabilization. …”
Get full text

Multivariate Cox regression analysis of prognostic genes and therapeutic mechanisms of gastric cancer by Yangyang Xiao, Zhiru Zhong, Chunli Yang, Zhiying Lin

“…Therefore, it is urgent to find new prognostic markers for the diagnosis and treatment of GC. Download gene expression matrix and clinical data from TCGA database and GSE84437 dataset. …”
Get full text