Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis by Stefania Bruno, Maria Beatriz Herrera Sanchez, Chiara Pasquino, Marta Tapparo, Massimo Cedrino, Ciro Tetta, Giovanni Camussi

“…HLSCs share with mesenchymal stromal cells the same phenotype, gene expression profile, and differentiation capabilities. …”
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Testing Homogeneity in a Semiparametric Two-Sample Problem by Yukun Liu, Pengfei Li, Yuejiao Fu

“…This problem arises naturally from many statistical applications such as test for partial differential gene expression in microarray study or genetic studies for gene mutation. …”
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Robust Semiparametric Optimal Testing Procedure for Multiple Normal Means by Peng Liu, Chong Wang

“…In high-dimensional gene expression experiments such as microarray and RNA-seq experiments, the number of measured variables is huge while the number of replicates is small. …”
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Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy by O. Lorenzo, E. Ramírez, B. Picatoste, J. Egido, J. Tuñón

“…In addition, the oxidation of fatty acids can saturate and cause their deposition in the cytosol, where they deviate to induce toxic metabolites or gene expression by nuclear-receptor interaction. Hyperglycemia, the fatty acid oxidation pathway, and the cytosolic storage of fatty acid and glucose/fatty acid derivatives are major inducers of reactive oxygen species. …”
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Microevolution during Chronic Infection May Lead T. asahii to Coexist with the Host by Gen Ba, Xuelian Lv, Xin Yang, Wenling Wang, Junhong Ao, Rongya Yang

“…During infection, microorganisms can adapt to their environment by adjusting gene expression and cellular activities. Objectives. Investigation of the microevolutionary changes in T. asahii during chronic infection. …”
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Epigenetic Application of ATAC-Seq Based on Tn5 Transposase Purification Technology by Wangchun Li, U Tim Wu, Yu Cheng, Yanhao Huang, Lipeng Mao, Menghan Sun, Congling Qiu, Lin Zhou, Lijuan Gao

“…These methods can provide a reference for the study of epigenetic regulation of gene expression.…”
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Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases by Ya-Min Ma, Lan Zhao

“…It is a powerful negative regulator of gene expression. It mediates the information exchange between different cellular pathways in cellular homeostasis and stress response and regulates the differentiation, plasticity, and neurotransmission of neurons. …”
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Non-coding RNAs and exosomal ncRNAs in colorectal cancer by Yalda Zhoulideh

“…In recent years, increasing attention has been paid to the role of non-coding RNA (ncRNA) and exogenous ncRNA in the development and progression of CRC. ncRNAs play an essential role in the regulation of gene expression and cell function, and dysregulation of ncRNA expression is associated with the onset and progression of CRC. …”
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Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome by Chilakamarti V. Ramana

“…Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, NF-kB, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. …”
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MicroRNAs in Human Pituitary Adenomas by Xu-Hui Li, Elaine Lu Wang, Hai-Meng Zhou, Katsuhiko Yoshimoto, Zhi Rong Qian

“…MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. …”
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Therapeutic Implications of PPARγ in Cardiovascular Diseases by Hiroshi Hasegawa, Hiroyuki Takano, Issei Komuro

“…Peroxisome proliferator-activated receptor-γ (PPARγ) is the members of the nuclear receptor superfamily as a master transcriptional factor that promotes differentiation of preadipocytes by activating adipose-specific gene expression. Although PPARγ is expressed predominantly in adipose tissue and associated with adipocyte differentiation and glucose homeostasis, PPARγ is also present in a variety of cell types including vascular cells and cardiomyocytes. …”
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ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells by Wen Du, Daimo Guo, Wei Du

“…Key events, including cell proliferation, lineage commitment, and MSC differentiation, are ensured by precise gene expression regulation. ATP-dependent chromatin alteration is one form of epigenetic modifications that can regulate the transcriptional level of specific genes by utilizing the energy from ATP hydrolysis to reorganize chromatin structure. …”
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Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor by Seong-Hoon Yun, Sang-Heum Han, Joo-In Park

“…Peroxisome proliferator-activated receptor γ (PPARγ) is part of a nuclear receptor superfamily that regulates gene expression involved in cell differentiation, proliferation, immune/inflammation response, and lipid metabolism. …”
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Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications by Gabriele Togliatto, Patrizia Dentelli, Maria Felice Brizzi

“…Particular effort has recently been devoted to understanding the functional relationship between chromatin structure regulation and the persistent change in gene expression which is driven by hyperglycaemia and which accounts for long-lasting diabetic complications. …”
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MiRNAs as major players in brain health and disease: current knowledge and future perspectives by Sarika V. Kapplingattu, Sujata Bhattacharya, Yogita K. Adlakha

“…Abstract MicroRNAs are regulators of gene expression and their dysregulation can lead to various diseases. …”
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Insights into Neonatal Oral Feeding through the Salivary Transcriptome by Jill L. Maron

“…Previously, our laboratory identified 9,286 genes in saliva that statistically significantly altered their gene expression as premature newborns gained advanced oral feeding skills. …”
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Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis by Zhengfang Liang, Fengwei Nong, Jingjie Zhao, Dalong Wei, Qianli Tang, Jian Song, Lingzhang Meng

“…In this study, natural killer (NK) cell populations were isolated using signature genes from the single-cell sequencing data of clear cell renal cell carcinoma (ccRCC) and normal kidney tissues and divided into three subpopulations according to the differences in gene expression profiles: NK(GZMH), NK(EGR1), and NK(CAPG). …”
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Single-cell RNA-seq data augmentation using generative Fourier transformer by Nima Nouri

“…To overcome this obstacle, we introduce scGFT (single-cell Generative Fourier Transformer), a train-free, cell-centric GM adept at synthesizing single cells that exhibit natural gene expression profiles present within authentic datasets. …”
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The role of feedback in the formation of morphogen territories by David Iron, Adeela Syed, Heidi Theisen, Tamas Lukacsovich, Mehrangiz Naghibi, Lawrence J. Marsh, Frederic Y. M. Wan, Qing Nie

“…Wedefine a gene regulatory network (GRN) that utilizes autoactivation and cross-inhibition (modeled by Hill equations) to establish and maintain stable bound-aries of gene expression. By computational analysis we find that in the presenceof a general activator, neither autoactivation, nor cross-inhibition alone are suf-ficient to maintain stable sharp boundaries of morphogen production in the legdisc. …”
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Assessment of SREBP Activation Using a Microsomal Vesicle Budding Assay by Mingfeng Xia, Tessa Edwards, Shunxing Rong

“…To be active, SREBPs are translocated to the Golgi where the transcriptionally active N-terminus is cleaved and released to the nucleus to regulate gene expression. Nuclear SREBP levels can be determined by immunoblot analysis; however, this method can only determine the steady-state levels of nuclear SREBPs and does not capture the actual status of activation. …”
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