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941
Antiviral Activity of Resveratrol against Human and Animal Viruses
Published 2015-01-01“…Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF-κβ pathway, while its antiviral effects are associated with inhibitions of viral replication, protein synthesis, gene expression, and nucleic acid synthesis. Although the beneficial roles of resveratrol in several viral diseases have been well documented, a few adverse effects have been reported as well. …”
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942
Biochemical Analysis of Histone Succinylation
Published 2017-01-01“…Histone PTMs are regarded as some of the most important, as they can directly regulate gene expression through chromatin reorganization. Recently, histone proteins were found to undergo succinylation, adding to other well-known PTMs such as acetylation, methylation, and phosphorylation. …”
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943
Alternative Splicing and Its Impact as a Cancer Diagnostic Marker
Published 2012-06-01“…Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. …”
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944
MicroRNAs in the Neural Retina
Published 2014-01-01“…For a long time, it was thought that the transcription factors were the only regulators of gene expression. More recently, however, a novel class of regulators emerged. …”
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945
Metabolic activities are selective modulators for individual segmentation clock processes
Published 2025-01-01“…While the segmentation clock tempo scales with the kinetics of gene expression and degradation processes of the core clock gene Hes7 across mammals, the coordination of these processes remains unclear. …”
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946
Aging in Persons with Rett Syndrome: An Updated Review
Published 2010-01-01“…Rett syndrome is the first human disease found to be caused by defects in a protein involved in regulating gene expression through its interaction with methylated DNA. …”
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947
Midregion PTHrP and Human Breast Cancer Cells
Published 2010-01-01“…The object of this review is to discuss collectively and critically both precedent and more updated data obtained in the lab, the latter arising from assays on DNA status, and gene and protein expression patterns of treated cells, aiming to check whether the cytotoxicity of the peptide may result from a reprogramming of gene expression towards apoptotic death or, instead, it is to be ascribed to an unprogrammed perturbation of cell functions.…”
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948
Specific Roles of MicroRNAs in Their Interactions with Environmental Factors
Published 2012-01-01“…MicroRNAs (miRNAs) have emerged as critical regulators of gene expression by modulating numerous target mRNAs expression at posttranscriptional level. …”
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949
Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals
Published 2025-01-01“…Transcription factors are fundamental to circadian rhythms, influencing gene expression, behavior in plants and animals, and human diseases. …”
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950
Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with
Published 2023-11-01“…Over the past several years, mechanotransduction, the mechanism by which mechanical perturbation influences gene expression and cellular behaviour, has recently gained popularity because of emerging data from both animal models and human studies of the pathogenesis of ankylosing spondylitis (AS). …”
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951
Expression of LGI1 Impairs Proliferation and Survival of HeLa Cells
Published 2009-01-01“…Expression of LGI1 increased the activity of apoptosis effectors caspase-3/7; furthermore it downregulated the antiapoptotic BCL2 gene and upregulated the proapoptotic BAX gene expression, suggesting that the cause of HeLa cells death might be an increased susceptibility to apoptosis induced by LGI1. …”
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952
The Heart-Placenta Axis in the First Month of Pregnancy: Induction and Prevention of Cardiovascular Birth Defects
Published 2013-01-01“…All three factors affected the important Wnt signaling pathway by suppressing Wnt-mediated gene expression in the heart fields, resulting in a delay of cardiomyocyte migration, cardiomyogenesis, and CHD. …”
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953
Shear Strength Model for Reinforced Concrete Corner Joints Based on Soft Computing Techniques
Published 2022-01-01“…Therefore, to overcome this challenge, two separate gene expression programming (GEP) based empirical models are developed for the shear strength of the corner joints, one under the opening moment and the other under the closing moments. …”
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954
Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review
Published 2022-01-01“…As to EBV, it was noted that its “hit and run” phenomenon manipulates the host epigenetic mechanism, triggering the tumor process without the virus being currently present; a “cellular reprogramming” is essentially generated, causing heritable changes in gene expression without DNA mutation. In conclusion, there is an association between oropharyngeal carcinogenesis and HPV and also between the former and EBV. …”
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955
Verification and Optimal Control of Context-Sensitive Probabilistic Boolean Networks Using Model Checking and Polynomial Optimization
Published 2014-01-01“…A BN is widely used as a model of GRNs, and gene expression is expressed by a binary value (ON or OFF). …”
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956
Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus
Published 2011-01-01“…Inhibition of CDK5 averts the decrease of insulin gene expression through the inhibition of nuclear translocation of PDX-1 which is a transcription factor for the insulin gene. …”
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957
Application of Spatial Transcriptomics in Digestive System Tumors
Published 2024-12-01“…In the field of digestive system tumor research, spatial transcriptomics technologies are used to delve into the spatial structure and the spatial heterogeneity of tumors and to analyze the tumor microenvironment (TME) and the inter-cellular interactions within it by revealing gene expression in tumors. These technologies are also instrumental in the diagnosis, prognosis, and treatment of digestive system tumors. …”
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958
Exploring the Revolutionary Impact of YAP Pathways on Physical and Rehabilitation Medicine
Published 2025-01-01“…However, the detailed molecular pathways through which these therapies interact with tissues and influence gene expression are not yet fully understood. The identification of YAP has been instrumental in closing this knowledge gap. …”
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959
miRNAomic Approach to Plant Nitrogen Starvation
Published 2021-01-01“…One of the important and recently discovered groups of regulatory molecules acting at the posttranscriptional and translational levels are microRNAs (miRNAs). miRNAs are known to play critical roles in the regulation of gene expression in plants under different stress conditions including N stress. …”
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960
Analysis of glutamate-dependent mechanism and optimization of fermentation conditions for poly-gamma-glutamic acid production by Bacillus subtilis SCP017-03.
Published 2025-01-01“…The introduction of glutamate substantially altered gene expression within the central metabolic pathway of cellular carbon. …”
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