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681
Alzheimer’s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function
Published 2025-01-01“…The details of AD pathogenesis have not been fully elucidated, and a comprehensive gene expression analysis of the process leading up to the onset of AD would be helpful for understanding the mechanism. …”
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682
lncRNAs: the unexpected link between protein synthesis and cancer adaptation
Published 2025-01-01“…We also expect to provide one of the first collective perspectives on the way these transcripts modulate gene expression beyond transcription.…”
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683
Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein.
Published 2025-01-01“…We recently characterized homeobox protein MSX-1 (MSX1) as a host restriction factor that inhibits HBV gene expression and genome replication by directly binding to HBV enhancer II/core promoter (EnII/Cp) and suppressing its promoter and enhancer activities. …”
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684
Ribosomes: An Exciting Avenue in Stem Cell Research
Published 2020-01-01“…Recent research suggests that specific ribosomes actively regulate gene expression in multiple cell types, such as stem cells. …”
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685
Spermatozoal Fractalkine Signaling Pathway Is Upregulated in Subclinical Varicocele Patients with Normal Seminogram and Low-Level Leucospermia
Published 2017-01-01“…In semen samples, fractalkine and CX3CR1 gene expression were investigated by qRT-PCR. Moreover, seminal plasma malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. …”
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686
Impact of dietary mulberry (Morus alba) fruit extract on the growth performance, skin color, and immune response of fancy carp (Cyprinus carpio)
Published 2025-03-01“…The present study aimed to investigate the effects of Mulberry (Mull) fruit extract on the growth performance, coloration, immune response, gene expression, and liver histology of fancy carp (Cyprinus carpio). …”
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687
Regulation of glycolipid and amino acid metabolism in juvenile triploid crucian carp (Carassius auratus) by oral administration of aspartic acid
Published 2025-03-01“…However, aspartic acid did not affect the gene expression of key enzymes involved in hepatic fatty acid β-oxidation. …”
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688
Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic live...
Published 2025-02-01“…Celastrol influenced the gene expression of galanin receptors: it downregulated Galr1 in the heart and upregulated Galr2 in the liver and Galr3 in the heart ventricles, potentially affecting energy metabolism, oxidative stress, and inflammation. …”
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689
Revealing the biological features of the axolotl pancreas as a new research model
Published 2025-01-01“…RNA sequencing was performed to profile global gene expression during larva and adult stages. And differential gene expression analysis was used to characterize the conserved and unique gene patterns in the axolotl pancreas. …”
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690
Biochemistry /
Published 2011Table of Contents: “…Carbohydrates, lipids, and amino acids : metabolic fuels and biosynthetic precursors -- Proteins and enzymes -- Membrane biochemistry and signal transduction -- Nutrition -- Generation of energy from dietary fuels -- Carbohydrate metabolism -- Lipid metabolism -- Nitrogen metabolism -- Integration of metabolism -- Nucleotide synthesis and metabolism -- Organization, synthesis, and repair of DNA -- Gene expression -- DNA technology -- Common laboratory values.…”
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691
Multiomics integration unravels genotype‐microbiome interactions shaping the conjunctival transcriptome
Published 2024-12-01“…Abstract Gene expression is a molecular phenotype shaped by the interplay between genotype and environment. …”
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692
Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei
Published 2025-02-01“…It was highly expressed by glutamatergic neurons in many thalamic regions by 14 PCW, sometimes but not always in conjunction with its upstream expression regulator FOXP2.ConclusionIn human discrete thalamic nuclei exhibiting discrete gene expression patterns emerge relatively early from a protomap of gene expression. …”
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693
Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats
Published 2025-02-01“…Results Our histological studies and bulk transcriptome gene expression analysis confirmed that both perirenal and omental adipose tissues (pAT and oAT) exhibited progressive whitening in goats. …”
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694
Identification and Validation of Pivotal Genes in Osteoarthritis Combined with WGCNA Analysis
Published 2025-01-01“…RT-qPCR and WB were further performed to verify the hub gene expression in OA rat.Results: In this study, 35 key genes were identified through differential expression analysis and weighted gene co-expression network analysis (WGCNA) using the GSE169077 and GSE114007 datasets. …”
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695
Transcriptome analysis of liver injury of fatty liver disease induced by ALDH2 deficiency
Published 2025-01-01“…In our controlled experiment with Aldh2-deficient mice, we induced fatty liver via alcohol and HiAlc Kpn gavage, followed by comprehensive analyses to detect gene expression and epigenetic changes. The results showed that Aldh2-deficient mice were particularly vulnerable to ethanol and HiAlc Kpn, with notable gene expression changes in key metabolic and liver injury pathways. …”
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696
Effects of Dietary Aflatoxin B1 on Hybrid Grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂) Growth, Intestinal Health, and Muscle Quality
Published 2024-01-01“…AFB1 negatively influenced hindgut tight junction protein and antioxidant-related gene expression while promoting inflammation-related gene expression. …”
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697
Identification of molecular characteristics in polycystic ovary syndrome using single-cell and transcriptome analysis
Published 2025-01-01“…Pseudotime trajectory analysis of cell subpopulations revealed the potential developmental trajectory of PCOS. The gene expression consistent with the potential developmental trajectory was validated by RT-qPCR. …”
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698
Comprehensive Bioinformatics Method to Explore Immune-Related Genes in the Pathogenesis of Myocardial Infarction
Published 2025-01-01“…We performed differential gene expression analysis, GO/KEGG enrichment analysis, protein-protein interaction (PPI) network analysis, weighted gene co-expression network analysis (WGCNA), gene set enrichment analysis, and immune infiltration studies to identify core immune-related genes associated with MI. …”
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699
Increased NOX-dependent ROS production and proportionally enhanced antioxidant response in white adipose tissue of male rats
Published 2025-01-01“…Materials and methods: The study analyzed the activity and gene expression of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, along with the production of NADPH oxidases dependent on H2O2 and gene expression of NOX1, NOX2, and NOX4. …”
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700
Islet Stellate Cells Isolated from Fibrotic Islet of Goto-Kakizaki Rats Affect Biological Behavior of Beta-Cell
Published 2016-01-01“…In the present study, we isolated “already primed by diabetic environment” ISCs from islets of Goto-Kakizaki rats, determined the gene profile of these cells, and assessed the effects of these ISCs on beta-cell function and survival. We detected gene expression of ISCs by digital gene expression. INS-1 cell proliferation, apoptosis, and insulin production were measured after being treated with ISCs supernatant (SN). …”
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