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621
Multiplexed transcriptomic analyzes of the plant embryonic hourglass
Published 2025-01-01“…In contrast, comparisons of embryonic gene expression among different animal phyla describe an inverse hourglass pattern, where expression is correlated during early and late stages but not during mid-embryo development. …”
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622
Carbon Black Particle Exhibits Size Dependent Toxicity in Human Monocytes
Published 2014-01-01“…Gene expression study showed upregulation of monocyte chemoattractant protein-1 gene while cyclooxygenase-2 gene remained unaffected. …”
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623
Covariate-adjusted construction of gene regulatory networks using a combination of generalized linear model and penalized maximum likelihood.
Published 2025-01-01“…This construction can be improved using the auxiliary information like gene expression profile of the related species or gene markers. …”
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624
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.
Published 2004-10-01“…However, persisting differential gene expression in hif-1 versus hif-1; vhl-1 double mutant worms clearly distinguished HIF-1-independent effects of VHL-1 inactivation. …”
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625
Hepatitis E rORF2p Stimulated and Unstimulated Peripheral Expression Profiling in Patients with Self-Limiting Hepatitis E Infection
Published 2014-01-01“…The phenotypic expressions of key molecules CTLA-4, GITR, CD103, CD25, CD69, IL10 and TGF-β1 in the acute patients and TGF-β1 in the recovered individuals were significantly elevated on both unstimulated and stimulated PBMCs. Gene expression array data revealed upregulations of CD25, PD1, CD103, CCR4, IL10, and TGF-β1 on both unstimulated and HEV rORF2p stimulated PBMCs of acute patients. …”
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626
Trajectory inference from single-cell genomics data with a process time model.
Published 2025-01-01“…Single-cell transcriptomics experiments provide gene expression snapshots of heterogeneous cell populations across cell states. …”
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627
Role of Epigenetic Histone Modifications in Diabetic Kidney Disease Involving Renal Fibrosis
Published 2017-01-01“…These imply that epigenetic factors modulate kidney gene expression. There is evidence to suggest that in diabetes and hyperglycemia, epigenetic histone modifications have a significant effect in modulating renal fibrotic and ECM gene expression induced by TGF-β1, as well as its downstream profibrotic genes. …”
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628
Identification and Validation of a Novel Immune Infiltration-Based Diagnostic Score for Early Detection of Hepatocellular Carcinoma by Machine-Learning Strategies
Published 2022-01-01“…To investigate the diagnostic gene biomarkers for hepatocellular carcinoma (HCC) and identify the immune cell infiltration characteristics in this pathology. Methods. Five gene expression datasets were obtained through Gene Expression Omnibus (GEO) portal. …”
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629
DYNAMICS OF IL12 CYTOKINE EXPRESSION IN HUMAN MACROPHAGES AFTER TREATMENT WITH DIOXIN
Published 2015-01-01“…In contrast, activation of IL12B gene expression with subsequent inhibition was noted. …”
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630
Administration of Iodine-125 Seeds Promotes Apoptosis in Cholangiocarcinoma through the PI3K/Akt Pathway
Published 2022-01-01“…We aimed to examine the effects of 125I seeds on the gene expression of Bcl-2, Bax, and PI3K/Akt pathway components in cholangiocarcinoma cells. …”
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631
Microarray Profiling of Lymphocytes in Internal Diseases With an Altered Immune Response: Potential and Methodology
Published 2005-01-01“…Here we review alterations of gene expression in lymphocytes and methodological aspects of the microarray technique in these diseases. …”
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632
Differential Effects of Calorie Restriction and Exercise on the Adipose Transcriptome in Diet-Induced Obese Mice
Published 2011-01-01“…Relative to the DIO controls, both CR and EX reduced adiposity by 35–40% and serum leptin levels by 80%, but only CR increased adiponectin and insulin sensitivity. Gene expression microarray analysis of visceral white adipose tissue revealed 209 genes responsive to both CR and EX, relative to the DIO group. …”
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633
qDATA - an R application implementing a practical framework for analyzing quantitative real-time PCR data
Published 2024-12-01“…Gene expression assays that are based on quantitative real-time PCR (qRT-PCR) method are still very popular, therefore, we developed qDATA, an open-source R-based bioinformatics application that offers a quick and intuitive analysis of raw cycle threshold (Ct) values. …”
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634
LASSO-mCGA: Machine Learning and Modified Compact Genetic Algorithm-Based Biomarker Selection for Breast Cancer Subtype Classification
Published 2025-01-01“…Being a heterogeneous disease, subtyping breast cancer plays a vital role in its treatment. In this regard, gene expression plays an important role. Thus, in this work gene expression data is used to identify the most significant gene biomarkers. …”
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635
Time-Space Translation: A Developmental Principle
Published 2010-01-01“…., the NOM) of the Xenopus gastrula. This early Hox gene expression is transient, unless it is stabilized by signals from the SO. …”
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636
Variational graph autoencoder for reconstructed transcriptomic data associated with NLRP3 mediated pyroptosis in periodontitis
Published 2025-01-01“…The model’s latent space distribution differed significantly from the original data, suggesting a tightly clustered representation of the gene expression patterns. K-means clustering and VGAE show promise in gene expression analysis and graph structure reconstruction for periodontitis research.…”
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637
Heterosis: current advances in the search for molecular mechanisms
Published 2016-12-01“…To date, differences in genome organization, gene expression and epigenetic status have been found between hybrids and their parents. …”
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638
Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis
Published 2023-01-01“…The aim of the study was to investigate the landscape of B-cell-related gene expression profiling in rheumatoid arthritis (RA) synovium and explore the biological and clinical significance of these genes in RA. …”
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639
Pparg may Promote Chemosensitivity of Hypopharyngeal Squamous Cell Carcinoma
Published 2020-01-01“…We integrated large-scale literature data and HSCC gene expression data to identify regulatory pathways that link PPARG and chemosensitivity in HSCC. …”
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640
Differentially Expressed Genes Study Shown Potential for BCG Stimulation in Reducing the Severity of COVID-19
Published 2022-01-01“…In this study, we used a differentially expressed genes (DEG) approach to analyze the genes modulated by BCG vaccination and COVID-19 infection. The Gene Expression Omnibus (GEO) database was used to select a COVID-19 gene expression data set with GSE164805, GSE14408, and GSE58636, and DEG in each data set were identified using the GEO2R online tools and selected using the adjusted p value (padj) 0.05 criteria. …”
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