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241
A missense variant in the SOX5 gene (c.221C > T) is associated with intellectual disability
Published 2025-02-01“…Western blots and QPCR were employed to assess gene expression and protein stability. Flow cytometry was utilized to compare the cell cycle dynamics between wild-type and mutant cells. …”
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242
CHOLINE TRANSPORTER-RELATED 4 (CTR4) Is Involved in Drought and Saline Tolerance in Rice
Published 2025-01-01“…Moreover, lipid synthesis gene expression was down-regulated in CTR4 mutants, potentially exacerbating membrane permeability defects and further compromising stress resistance. …”
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243
Microbiology /
Published 2005Table of Contents: “…The history and scope of microbiology -- The study of microbial structure: microscopy and specimen preparation -- Procaryotic cell structure and function -- Eucaryotic cell structure and function -- Microbial nutrition -- Microbial growth -- Control of microorganisms by physical and chemical agents -- Metabolism: energy, enzymes, and regulation -- Metabolism: energy release and conservation -- Metabolism: the use of energy in biosynthesis -- Genes: structure, replication, and mutation -- Genes: expression and regulation -- Microbial recombination and plasmids -- Recombinant DNA technology -- Microbial Genomics -- The viruses: introduction and general characteristics -- The viruses: bacteriophages -- The viruses: viruses of eucaryotes -- Microbial taxonomy -- The archaea -- Bacteria: the deinococci and nonproteobacteria gram negatives -- Bacteria: the proteobacteria -- Bacteria: the Low G 1 C gram positives -- Bacteria: the High G 1 C gram positivies -- The fungi (eumycota), slime molds, and water molds -- The algae -- The protozoa -- Microorganism interactions and microbial ecology -- Microorganisms in aquatic environments -- Microorganisms in terrestrial environments -- Normal microbiota and nonspecific host resistance -- Specific immunity -- Medical immunology -- Pathogenicity of microorganisms -- Antimicrobial chemotherapy -- Clinical microbiology -- The epidemiology of infectious disease -- Human diseases caused by viruses -- Human diseases caused by bacteria -- Human diseases causedd by fungi and protozoa -- Microbiology of food -- Industrial microbiology and biotechnology.…”
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244
Contribution of cuproptosis and immune-related genes to idiopathic pulmonary fibrosis disease
Published 2025-02-01“…Additionally, multiple bioinformatics analyses were employed to identify immune-related biomarkers associated with the diagnosis of IPF, offering valuable insights for future treatment strategies.MethodsFour microarray datasets were selected from the Gene Expression Omnibus (GEO) collection for screening. …”
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245
Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics
Published 2025-02-01“…COX11 was the key gene for co-morbidities: in tumor tissues, COX11 expression was significantly higher than that in normal colon tissues. However, COX11 gene expression was significantly lower in patients with comorbidities than in patients without T2DM in tumor tissue. …”
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246
Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging
Published 2025-02-01“…For example, donor-derived cell-free DNA (dd-cfDNA) is highly sensitive in detecting early graft injury, whereas gene expression profiling effectively excludes moderate-to-severe acute rejection (AR). …”
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247
Endogenous 17β-estradiol regulates sexually dimorphic anxiety responses in zebrafish via the HPI axis and 5-HT/DA pathways
Published 2025-02-01“…Conversely, E2 treatment in males (E2-M) increased E2 levels and anxiety responses, elevated plasma cortisol levels, and decreased brain 5-HT and DA content, with corresponding changes in gene expression. These findings strongly suggest that E2 positively regulates sexually dimorphic anxiety responses possibly by modulating plasma cortisol levels and the synthesis and action of 5-HT/DA in the brain.…”
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248
Exposure to triphenyl phosphate during pregnancy: The role of gut-bile acids-liver axis on lipid metabolism in male offspring
Published 2025-01-01“…Target bile acids (BAs) metabolites analysis revealed a significant increased levels of primary BAs cholic acid (CA), but decreased levels of chenodeoxycholic acid (CDCA), and decreased levels of the secondary BAs deoxycholic acid (DCA), hyodeoxycholic acid (HDCA), ursodeoxycholic acid (UDCA), and lithocholic acid (LCA) in TPhP treatment group. Measurements of gene expression along the gut-BAs-liver axis showed that the TPhP treatment group had an increase in cholesterol-7alpha-hydroxylase (CYP7A1) and a decrease in apical sodium-dependent bile acid transporter (ASBT), with only the low-dose group exhibiting an increase in carbohydrate response element binding protein (ChREBP). …”
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249
Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration
Published 2025-02-01“…Conclusions Overall, this integrative transcriptomic approach identified several new shared and disparate genes associated with regional vulnerability with increased biological interpretation including overlap with synaptic density maps and pathologically-specific gene expression. These findings illuminated the intricate molecular underpinnings contributing to the heterogeneous nature of disease distribution in bvFTD with distinct genetic backgrounds.…”
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250
Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis
Published 2025-02-01“…MethodsWe performed genome-wide transcriptome analysis comparing gene expression profile of metastatic thyroid cancer cells (Met) with primary tumor cells established from transgenic mouse models of papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC).ResultsGenes involved in tumor microenvironment (TME), inflammation, and immune escape were significantly overexpressed in Met cells. …”
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251
Integrated analysis of biochemical, transcriptomic, and metabolomic response mechanisms in Ussuri catfish (Pseudobagrus ussuriensis) under acute heat stress
Published 2025-01-01“…However, research on heat stress in P. ussuriensis, particularly concerning gene expression and metabolites, remains limited. In this study, we conducted histological observations, biochemical measurements, transcriptomic analysis, and metabolomic analysis on liver tissue from a control group (22 ℃), an acute heat stress group (34 ℃, with samples taken at 0, 3, 6, 12, and 24 h), and a recovery group (sampled 24 h after recovery to 22 ℃). …”
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252
IFN-γ reprograms cardiac microvascular endothelial cells to mediate doxorubicin transport and influences the sensitivity of mice to doxorubicin-induced cardiotoxicity
Published 2025-01-01“…Single-cell RNA sequencing revealed differences of gene expression in cardiac endothelial cells between DIC-insensitive and DIC-sensitive groups. …”
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253
Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin
Published 2025-05-01“…Single-cell analysis of affected skin showed polyclonal TH17-like cells with gene expression signatures similar to T-cell response during prevalent infectious diseases. …”
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254
Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken
Published 2025-02-01“…Conclusion Our study characterized the dynamic profile of genome-wide gene expression in ovary and highlighted the role of dominant expression of cell cycle pathway genes in heterosis. …”
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255
miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA
Published 2025-03-01“…We found that transfection of LMH cells with miR124a-3p inhibitor alleviated the changes in GR and metabolic detoxification enzyme gene expression induced by AFB1. Additionally, AFB1-induced reductions in cell viability, increased apoptosis, inhibited proliferation, oxidative stress, and DNA damage were also alleviated. …”
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256
Interaction of dietary replacements of fishmeal by protein blend and feeding frequency on growth performance and protein utilization of gibel carp (Carassius gibelio var. CAS V)
Published 2025-03-01“…Notably, the adverse effects observed with blended proteins (ratio at 1:1:8:2) on total essential amino acid digestibility and muscle protein metabolism-related gene expression were mitigated with increased feeding frequency, thus alleviating growth inhibition. …”
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257
DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells
Published 2021-05-01“…Moreover, FLT3LG and CCL5 or CCR5 gene expression signatures correlate with an enhanced cDC1 signature and a favorable overall survival in patients with cancer. …”
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258
NALCN expression is down-regulated and associated with immune infiltration in gastric cancer
Published 2025-02-01“…Data obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were utilized to investigate the correlation between NALCN expression and immune cell infiltration in GC. …”
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259
Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens
Published 2025-02-01“…The CHF supplementation increased the glutathione peroxidase level (P < 0.05) and upregulated gene expression related to the Nrf2 pathway (including HO-1, P < 0.05; Nrf2, P = 0.098; CAT, P = 0.060; GPX1, P = 0.063; and SOD2, P = 0.052) and lipid metabolism (including PPARγ, P < 0.05; SREBP1, P = 0.059; and CPT1A, P = 0.058). …”
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260
Multi-omics and machine learning-driven CD8+ T cell heterogeneity score for head and neck squamous cell carcinoma
Published 2025-03-01“…By analyzing the gene expression related to CD8+ T cells, we have differentiated HNSCC into cold and hot tumor subtypes, uncovering disparities in clinical prognosis and responses to immunotherapy. …”
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