Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

“…To characterize the potential value of AA metabolism related genes in the diagnosis and progression of CKD. Methods: We filtered the key genes associated with AA metabolism based on the least absolute shrinkage and selection operator (LASSO) and SVM algorithm. …”
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Copper Super-Dosing Improves Performance of Heat-Stressed Broiler Chickens through Modulation of Expression of Proinflammatory Cytokine Genes by Sudipto Haldar, Amrita Kumar Dhara, Sayantani Sihi Arora, Arpana Verma Mukherjee, Arup Nayak

“…Interleukin-6 and tumour necrosis factor-α gene expression increased linearly (P=0.0001) as Cu in the diet increased though the response plateaued at 112.5 mg/kg. …”
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Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia by Tao Liu, Yang Wang, Xi-Zhou An, Jiaqi Liu, Yuqin Wu, Yan Xiang, Yong-Jie Zhang, Lan Huang, Jia-Cheng Li, Yu-Zhuo-Pu Li, Jie Yu

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A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population by Metha Yaikwawong, Pornpimon Ek-eudomsuk, Gunya Sittithumcharee, Vipavee Anupunpisit, Thavatchai Peerapatdit, Chaicharn Deerochanawong, Thep Himathongkam, Siwanon Jirawatnotai, Somlak Chuengsamarn

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Human APP Gene Expression Alters Active Zone Distribution and Spontaneous Neurotransmitter Release at the Drosophila Larval Neuromuscular Junction by Ekaterina A. Saburova, Alexander N. Vasiliev, Violetta V. Kravtsova, Elena V. Ryabova, Andrey L. Zefirov, Olga I. Bolshakova, Svetlana V. Sarantseva, Igor I. Krivoi

“…Human APP gene expression increased the number of synaptic boutons per neuromuscular junction. …”
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Decitabine Increases the Transcription of <i>RIG-I</i> Gene to Suppress the Replication of Feline Calicivirus and Canine Influenza Virus by Shaotang Ye, Zhen Wang, Aolei Chen, Ying Chen, Gaoming Lou, Qingmei Xie, Gang Lu, Shoujun Li

“…Decitabine has been proven to modulate gene expression through its demethylating effect. …”
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POLYMORPHISM VITAMIN D RECEPTOR GENE (VDR) BSMI (RS1544410) CHRONIC PERIODONTITIS PATIENT IN JAVANESE BANYUMAS ETHNIC by Ryana Budi Purnama, Setiadi Warata Logamarta, Agung Dhartono

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Pituitary adenoma: literature review and association with TAS2R16 (rs978739, rs1357949) gene polymorphisms by E. Pileckaitė, G. Gedvilaitė, L. Kriaučiūnienė

“…A recent study has investigated the association of TAS2R16 gene single nucleotide polymorphisms (SNPs) with colon cancer, as SNPs in this gene have been found to increase alcohol dependence. …”
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Mini-review: Utilization of Vibrio parahaemolyticus virulence coding genes for early detection of acute hepatopancreatic necrosis disease (AHPND) by Munti Yuhana, Usamah Afiff

“…Several types of potential genes that can be developed into tracking devices for infectious Vibriosis are pathogenic genes encoding the virulence factor. …”
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Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin by Nádia Bertoncello, Roseli Peres Moreira, Danielle Yuri Arita, Danielle S. Aragão, Ingrid Kazue Mizuno Watanabe, Patricia S. Dantas, Ralmony Santos, Rodolfo Mattar-Rosa, Rodrigo Yokota, Tatiana Sousa Cunha, Dulce Elena Casarini

“…Increased number of copies of the Ace gene, associated with DM, induces renal dysfunction. …”
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Covariate-adjusted construction of gene regulatory networks using a combination of generalized linear model and penalized maximum likelihood. by Omid Chatrabgoun, Alireza Daneshkhah, Parisa Torkaman, Mark Johnston, Nader Sohrabi Safa, Ali Kashif Bashir

“…Many machine learning techniques have been used to construct gene regulatory networks (GRNs) through precision matrix that considers conditional independence among genes, and finally produces sparse version of GRNs. …”
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Resistance of <i>Wolbachia</i> to Trimethoprim: Insights into Genes Encoding Dihydrofolate Reductase, Thymidylate Synthase and Serine Hydroxymethyltransferase in the Rickettsiales by Ann M. Fallon

“…In the Rickettsiales, serine hydroxymethyltransferase (SMHT), encoded by a conserved <i>glyA</i> gene, regenerates methylene tetrahydrofolate. Unlike <i>thyA</i>, <i>thyX</i> lacks a human counterpart and thus provides a potential target for the treatment of infections caused by pathogenic members of the Rickettsiales.…”
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Development and functional validation of a disulfidoptosis-related gene prognostic model for lung adenocarcinoma based on bioinformatics and experimental validation by Tao Shen, Tao Shen, Zhuming Lu, Sisi Yang, Dongxi Zhang, Yongwen Ke, Zhuowen Chen, Jinqiang Wu, Jinqiang Wu, Weidong Wu

“…Tensin4 (TNS4), a key gene in the model, was further evaluated through immunohistochemistry (IHC) in LUAD and normal tissues and gene knockdown experiments in vitro.ResultsTwo clusters were identified, with 225 differentially expressed genes. …”
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Sparse Gene Coexpression Network Analysis Reveals EIF3J-AS1 as a Prognostic Marker for Breast Cancer by Xin Chen, Zuyuan Yang, Chao Yang, Kan Xie, Weijun Sun, Shengli Xie

“…The differentially expressed genes were significantly overlapped with gene modules regulating cell cycle and cell adhesion. …”
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Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease by Zhihao Qi, Quan Li, Shuhua Yang, Chun Fu, Burong Hu

“…We elected from genetic variants located within or near 2000 DDR-related genes in cis, which are closely associated with DDR-related gene changes. …”
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Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARα by Bianca Knoch, Matthew P. G. Barnett, Janine Cooney, Warren C. McNabb, Diane Barraclough, William Laing, Shuotun Zhu, Zaneta A. Park, Paul MacLean, Scott O. Knowles, Nicole C. Roy

“…The interleukin-10 gene-deficient (Il10-/-) mouse is a model of human inflammatory bowel disease and Ppara has been identified as one of the key genes involved in regulation of colitis in the bacterially inoculated Il10-/- model. …”
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Diverse Effects of Lead Nitrate on the Proliferation, Differentiation, and Gene Expression of Stem Cells Isolated from a Dental Origin by Mariam Abdullah, Fazliny Abd. Rahman, Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Noor Hayaty Abu Kasim, Sabri Musa

“…Our study revealed for the first time that Pb2+ exposure not only affects the phenotypic characteristics but also induces significant alteration in the differentiation and gene expression in the cells.…”
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Overusage of Mouse DH Gene Segment, DFL16.1, IsStrain-Dependent and Determined by cis-Acting Elements by Michael J. Atkinson, Yenhui Chang, Jakub W. Celler, Carol Huang, Christopher J. Paige, Gillian E. Wu

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Genetic investigation of patients with autosomal recessive ataxia and identification of two novel variants in the SQSTM1 and SYNE1 genes by Diana Mokhtari, Mohammad Jahanpanah, Nasim Jabbari, Hamed Azari, Sana Davarnia, Haleh Mokaber, Sara Arish, Rasol Molatefi, Vahid Abbasi, Behzad Davarnia

“…Therefore, comprehensive genetic testing is useful for identifying the genes responsible for ARCAs. We identified two novel pathogenic variants of the SQSTM1 and SYNE1 genes via whole-exome sequencing in patients with ARCAs.…”
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Detecting gene copy number alterations by Oncomine Comprehensive genomic profiling in a comparative study on FFPE tumor samples by Fabio Bozzi, Elena Conca, Marco Silvestri, Gianpaolo Dagrada, Alice Ardore, Donata Penso, Daniele Lorenzini, Chiara Costanza Volpi, Desirè Viola Trupia, Adele Busico, Iolanda Capone, Federica Perrone, Elena Tamborini, Andrea Vingiani, Luca Agnelli, Giancarlo Pruneri

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