The combination of polystyrene microplastics and di (2-ethylhexyl) phthalate promotes the conjugative transfer of antibiotic resistance genes between bacteria by Yu Li, Xiaomei Liu, Saisai Guo, Lan Wang, Jingchun Tang

Subjects: Get full text

Budd-Chiari Syndrome with Multiple Thrombi due to a Familial Arg42Ser Mutation in the Protein C Gene by Jun Muratsu, Atsuyuki Morishima, Kazuhiro Mizoguchi, Keiji Ataka, Hiroshi Yamamoto, Xinping Fan, Toshiyuki Miyata, Katsuhiko Sakaguchi

“…Genetic analysis showed the presence of a c.125C>A (Arg42Ser) substitution in the protein C gene (PROC) of the proband, which generates an Arg42Ser mutation that replaces the scissile bond Arg42-Ala43 normally cleaved by a furin-like processing protease. …”
Get full text

JUNB O‐GlcNAcylation‐Mediated Promoter Accessibility of Metabolic Genes Modulates Distinct Epithelial Lineage in Pulmonary Fibrosis by Marie‐Therese Bammert, Meshal Ansari, Leoni Haag, Zuhdi Ahmad, Victoria Schröder, Joseph Birch, Diana Santacruz, Werner Rust, Coralie Viollet, Benjamin Strobel, Alec Dick, Florian Gantner, Holger Schlüter, Fidel Ramirez, Muriel Lizé, Matthew J. Thomas, Huy Q. Le

“…This remodeling is characterized by an increase in chromatin accessibility, particularly at JUNB motif‐enriched promoter regions proximal to transcription start sites of metabolic and pro‐fibrotic genes. Mechanistically, JUNB undergoes O‐linked β‐N‐acetylglucosamine modification (O‐GlcNAcylation), a critical step in modulating pro‐fibrotic responses to chronic injury. …”
Get full text

The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome by Blazej Misiak, Marta Krolik, Anna Kukowka, Anna Lewera, Przemyslaw Leszczynski, Joanna Stankiewicz-Olczyk, Ryszard Slezak

“…Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). …”
Get full text

Genome-wide identification of the bHLH gene family in Scutellaria baicalensis and their relationship with baicalin biosynthesis under drought stress by Yingxin Sun, Beier Wang, Lichao Zhang, Xiaohan Zheng, Peng Xu, Meng Zhang, Meiguang Han, Peng Di, Mei Han, Lin Cheng, Limin Yang

Subjects: Get full text

An association study of polymorphisms in the P2RX7 gene in an Iranian population with the risk of type 2 diabetes mellitus by Homa Noori, Majid Rajabian, Mahdi Majidpour, Mahboobeh Sabeti Akbar-Abad, Ramin Saravani

“…The current study evaluated the association of two variants through the purinergic receptor P2X7 (P2RX7) gene with the incidence of T2DM in the population of Iran. …”
Get full text

Functional genomic imaging (FGI), a virtual tool for visualization of functional gene expression modules in heterogeneous tumor samples by Xinlei Chen, Youbing Guo, Xiaorong Gu, Danyi Wen

“…These gene modules were annotated and projected onto a t-SNE map for visualization. …”
Get full text

Fructan Biosynthetic and Breakdown Enzymes in Dicots Evolved From Different Invertases. Expression of Fructan Genes Throughout Chicory Development by Wim Van den Ende, An Michiels, Joke De Roover, Andrea Van Laere

“…Unlike fructan biosynthetic genes that originated from vacuolar-type invertase, fructan exohydrolases (FEHs) seem to have evolved from a cell-wall invertase ancestor gene that later obtained a low iso-electric point and a vacuolar targeting signal. …”
Get full text

Bacterial Quality and Molecular Detection of Food Poisoning Virulence Genes Isolated from Nasser Lake Fish, Aswan, Egypt by Nady Khairy Elbarbary, Mohamed K. Dandrawy, Ghada Hadad, Maha Abdelhaseib, Amna A. A. Osman, Rawaf Alenazy, Ibrahim Elbagory, Neveen M. Abdelmotilib, Fagelnour Elnoamany, Ghada A. Ibrahim, Reda A. Gomaa

“…Additionally, PCR analysis detected the presence of aerA (60%) and Act (40%) genes in A. hydrophila, rpoB (70%) and LasB (30%) genes in P. aeruginosa, and ToxR (70%) and tdh (50%) genes in V. parahaemolyticus. …”
Get full text

Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms by E. V. Ignatieva, E. A. Matrosova

“…The present review focuses on the molecular genetic mechanisms by which pathogenic genetic variants affect gene expression. At the same time, attention is concentrated on the transcriptional level of regulation as an initial step in the expression of any gene. …”
Get full text

Genetic Transformability of Selected Kenyan Groundnut (Arachis hypogaea L.) Genotypes with IPT Gene Using Cotyledonary Node Explants by Purity G. Limbua, Mathew P. Ngugi, Richard O. Oduor

“…The vector also contained the phosphomannose isomerase (PMI) gene for the selection of transformed tissues. Putative transformants were tested for the presence of the transgene by PCR designed to amplify the IPT gene sequence. …”
Get full text

Hybrid Carbohydrate–Lipid Nanocarriers: In Vitro Efficacy Gene-Rated by Association of UV-Absorbers and Raspberry Polyphenols Rich-Fraction by Nicoleta Badea, Diego Samayoa, Alina Moroşan, Cristina Ott, Ioana Lacatusu

Get full text

Effective leaf rust resistance genes of wheat in Novosibirsk Province in connection with the variability of the <i>Puccinia triticina</i> population by L. P. Sochalova, N. I. Boyko, A. A. Poteshkina, V. V. Piskarev

Subjects: Get full text

Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools by Nur Alia Natasya Zabidi, Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Nur Alyaa Afifah Md Shahri, Francis Tieng Yew Fu, Imilia Ismail, Muhammad Redha Abdullah Zawawi, Jodi Woan-Fei Law, Learn-Han Lee, Nurul-Syakima Ab Mutalib

“…The molecular mechanisms underlying CRC, especially DNA methylation patterns in solute carrier (SLC) genes, have gained attention due to their potential role in CRC initiation and progression. …”
Get full text

Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients by Vinodh Kumar Radhakrishnan, Lorraine Christine Hernandez, Kendra Anderson, Qianwei Tan, Marino De León, Daisy D. De León

“…Tumors with biallelic IGF-II gene expression exhibited the highest levels of proIGF-II and Survivin. …”
Get full text

Exposure to Early Life Stress Results in Epigenetic Changes in Neurotrophic Factor Gene Expression in a Parkinsonian Rat Model by Thabisile Mpofana, Willie M. U. Daniels, Musa V. Mabandla

“…Further to this, we found higher DNA methylation and decreased neurotrophic factor gene expression. 6-OHDA lesion increased neurotrophic factor gene expression in both stressed and nonstressed rats but this increase was higher in the nonstressed rats. …”
Get full text

Correction: Antimicrobial resistance, virulence gene profiling, and genetic diversity of multidrug-resistant Pseudomonas aeruginosa isolates in Mazandaran, Iran by Ghazaleh Elahi, Hamid Reza Goli, Morvarid Shafiei, Vajihe Sadat Nikbin, Mehrdad Gholami

Get full text

Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of <i>Ganoderma lucidum</i> by Xiaolan Xu, Chunxia Li, Fangjing Wu, Shuangshuang Zhao, Tiqiang Chen, Haihong You, Yijie Lin, Xiaoxing Zou

“…A transcriptomics analysis showed that there were 371 DEGs in the P_vs_FM group, including 171 down-regulated genes and 200 up-regulated genes. In the FM_vs_FP group, 2567 DEGs were identified, with 1278 down-regulated genes and 1289 up-regulated genes. …”
Get full text

Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population by Monika Chorąży, Natalia Wawrusiewicz-Kurylonek, Edyta Adamska-Patruno, Olga Zajkowska, Katarzyna Kapica-Topczewska, Renata Posmyk, Adam Jacek Krętowski, Jan Kochanowicz, Alina Kułakowska

“…The heterozygous genotype TC (rs1883832) of CD40 gene was more common in the control subjects, and the frequency of the alleles and genotypes in the rs1748033 of the PADI4 gene did not differ between the studied groups. …”
Get full text

Expression Characterization of Six Genes Possibly Involved in Gonad Development for Stellate Sturgeon Individuals (Acipenser stellatus, Pallas 1771) by Alexandru Burcea, Gina-Oana Popa, Iulia Elena Florescu (Gune), Marilena Maereanu, Andreea Dudu, Sergiu Emil Georgescu, Marieta Costache

“…We analysed the gene expression of the selected genes for gonads, anal fin, liver, body kidney, and white muscle. …”
Get full text