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  1. 14481

    Kûfe ve Basra Nahiv Ekollerinin Sahîh Kıraatleri Değerlendirme Yöntemleri by Hüseyin Yaşar, Cihat Çelik

    Published 2024-06-01
    “…Bu iki ekole mensub dilbilimcilerin geneli de sonraki dönemlerde kıraat farklılıklarını dil ve iʿrab yönünden değerlendirmişler, fasih ve beliğ kıraat vecihlerini belirleme noktasında gramer kaideleri ile ihticâca yönelmişlerdir. …”
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  2. 14482

    La escuela inclusiva: una oportunidad para humanizarnos by Miguel López Melero

    Published 2012-01-01
    “…Somos lo que somos gracias a las oportunidades que hemos tenido y no a los genes. Ahora bien, lo más humano del ser humano es desvivirse por otro ser humano y en este desvivir surge el valor ético de la educación. …”
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  3. 14483

    Antibiotic resistance genotype, phenotype, and clinical outcomes in patients with Gram-negative infections at Rabin Medical Center in Israel by Rachelle E. Koch, Jackson Barth, Andrew E. Clark, Dhara Desai, Jiwoong Kim, Christine A. Pybus, Xiaowei Zhan, Leonard Leibovici, Dafna Yahav, David E. Greenberg

    Published 2025-01-01
    “…We performed whole-genome sequencing on five medically important pathogens (Acinetobacter baumannii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa) to investigate how resistance genes impact patient outcomes. A total of 168 isolates from 162 patients with Gram-negative infections admitted to Beilinson Hospital at Rabin Medical Center in Israel were included for final analysis. …”
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  4. 14484
  5. 14485

    XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity by Kun Chen, Fei Zhao, Hong Zhao, Dongmei Wang, Chunfeng Qu, Zhiyuan Wu, Feifei Wang, Xing-Ning Li, Ruochan Zhang, Chentong Xiao, Yuliang Ran

    Published 2025-01-01
    “…We modified CEA-specific CAR-T cells, aiming to stimulate endogenous CD8+ T cell responses against neoantigens that were derived from CEA-positive tumors destroyed by the CAR T cells.Methods In a conventional CEA CAR (reg-CAR), we modified it to express lymphotactin XCL1 and interleukin (IL)-7 genes, constructing a modified 7XCL1-CAR. By generating the CEA-specific 7XCL1-CAR T cells, we assessed their antitumor efficacy against CRC cells with varying levels of CEA expression, both in cell-cultures and in two strains of tumor-bearing syngeneic mice.Results Following retroviral transduction, 7XCL1-CAR T cells and reg-CAR T cells exhibited similar positive proportions of CEA-CAR and CD4:CD8 ratios. …”
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  6. 14486

    Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications by Jiayi He, Huiqian Zhang, Hehua Quan, Qingyuan Wang, Congcong Wen, Yiyan Wang, Yang Zhu, Ren-Shan Ge, Xiaoheng Li

    Published 2025-02-01
    “…BPB did not alter the numbers of CYP11A1+ Leydig cells and SOX9+ Sertoli cells, but it downregulated the expression of key genes in testosterone synthesis pathway (Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Hsd11b1, Hsd17b3, and Insl3) and their corresponding protein levels. …”
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  7. 14487

    Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

    Published 2025-02-01
    “…Reductions in all NK cell subtypes were observed at M3, CD16lowCD56bright and NKp46 cells reconstituted at M6 and M12 respectively. Changes in genes and pathways associated with innate and adaptive immune response were observed after CladT treatment, along with reductions in pro-inflammatory cytokine-producing B and T cells and increases in anti-inflammatory cytokine-producing T cells. …”
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  8. 14488

    Integrated microbiome, transcriptome and metabolome insight into the alleviating mechanisms of sheep milk in a DSS-induced colitis mouse model by Wenna Yao, Ruilin Du, Shuo Yan, Teligun Bao, Huimin Zhang, Fang Yang, Yue Xue, Yulong Zhao, Siqin Bao, Xihe Li, Yongli Song

    Published 2025-02-01
    “…Transcriptome analysis demonstrated that the expression of genes related to the IL-17 signaling and PI3K-Akt signaling pathways, such as S100A8, S100A9, LNC2, CXCL3, CREB313, CREB314 and CHRM1 were downregulated in the SM group compared to the DSS group. …”
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  9. 14489
  10. 14490
  11. 14491

    Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere by R. Jin, W. Hu, W. Hu, P. Duan, M. Sheng, D. Liu, Z. Huang, M. Niu, L. Wu, J. Deng, P. Fu, P. Fu

    Published 2025-02-01
    “…Annotation through the Kyoto Encyclopedia of Genes and Genomes database helped identify metabolic processes. …”
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  12. 14492
  13. 14493
  14. 14494

    Petrogenesis of Intrusive body in Northeast of Joveinan, North of Isfahan, Urumieh- Dokhtar magmatic zone by Shahzad Sherafat, Majid Zeidi, Mahnaz Khodami

    Published 2024-10-01
    “…The primary mantle normalized pattern shows the enrichment of large ion lithophile elements (LILE) and depletion of high field strength elements (HFSE), which is one of the geochemical characteristics of the magma related to the subduction zone (Kuscu and Geneli, 2010). The chondrite-normalized rare earth elements diagrams show a medium enrichment of LREE compared to HREE, a weak negative anomaly of Europium, and a flat pattern of heavy rare earth elements. …”
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