Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations by D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda

“…Mutations in the CYP1B1 gene, which encodes cytochrome P450 1B1, are the most common cause of autosomal recessive primary congenital glaucoma. …”
Get full text

First two mitochondrial genomes for the order Filobasidiales reveal novel gene rearrangements and intron dynamics of Tremellomycetes by Qiang Li, Zhijie Bao, Ke Tang, Huiyu Feng, Wenying Tu, Lijiao Li, Yunlei Han, Mei Cao, Changsong Zhao

Subjects: Get full text

Effect of Nitrogen Source and Inorganic Phosphate Concentration on Methanol Utilization and PEX Genes Expression in Pichia pastoris by A. M. Rumjantsev, O. V. Bondareva, M. V. Padkina, E. V. Sambuk

“…In biotechnology it is very important to maintain the balance between high levels of heterologous gene expression and cell viability. Decisive understanding of gene regulation mechanisms is essential for reaching this goal. …”
Get full text

Association of the EPAS1 gene G/A polymorphism with successful performance in a group of Russian wrestlers by E. A. Bondareva, E. Z. Godina

“…A large number of studies showed that the gene EPAS1 may serve as a possible predictor of success in sports because of its influence on the processes of oxygen transportation and consumption. …”
Get full text

Genetic association of lipid-lowering drug target genes with pancreatic cancer: a Mendelian randomization study by Bohan Su, Zhiyao Fan, Jiexi Wu, Hanxiang Zhan

“…Genetic variants associated with lipid traits and variants of genes encoding lipid-lowering drug targets were extracted from the Global Lipids Genetics Consortium genome-wide association study (GWAS). …”
Get full text

Carbapenem resistance in gram-negative pathogens in an Iranian hospital: high prevalence of OXA-type carbapenemase genes by Setareh Mamishi, Reihaneh Hosseinpour Sadeghi, Sadaf Sajedi Moghaddam, Babak Pourakbari, Shiva Poormohammadi, Maryam Sotoudeh Anvari, Shima Mahmoudi

“…Polymerase chain reaction was used to detect carbapenem resistance genes including bla OXA23, bla OXA24, bla OXA48, bla OXA51, bla OXA58, bla OXA143, bla KPC, bla IMP, bla VIM, and bla NDM. …”
Get full text

Heterologous Expression and Adaptive Evolution of ε-Poly-lysine Synthase Gene in <i>Corynebacterium glutamicum</i> by Long Pan, Yihang Chen, Aimei Liao, Yinchen Hou, Jihong Huang

“…Its ability to produce high amounts of L-lysine can provide sufficient precursor substances for the synthesis of ε-PL, making it an ideal strain for the heterologous expression of ε-PL synthase genes (<i>pls</i>). In this experiment, a recombinant <i>C. glutamicum</i> capable of synthesizing ε-PL and exhibiting certain physiological resistance to ε-PL was obtained by amplifying <i>pls</i> and heterologous expression in <i>C. glutamicum</i> for the first time. …”
Get full text

Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…Abstract Background Identifying markers or genes crucial for growth traits in Zhongwei goats is pivotal for breeding. …”
Get full text

Treatment of Cancer Gene Changes in Chronic Myeloid Leukemia by Big Data Analysis Platform-Based Dasatinib by Linlin Song, Qi Li, Hui Shi, Pengxia Zhang

“…The results showed that the IEAS system could incorporate the gene expression analysis vectors it contained by JAVA-related technologies, and the generated clustering genes showed similar functions. …”
Get full text

Generation and analysis of mouse embryonic stem cells with knockout of the <i>Mcph1</i> (microcephalin) gene by A. M. Yunusova, A. V. Smirnov, T. A. Shnaider, I. E. Pristyazhnuk, S. Y. Korableva, N. R. Battulin

Subjects: Get full text

Hearing Screening Combined with Target Gene Panel Testing Increased Etiological Diagnostic Yield in Deaf Children by Le Xie, Yue Qiu, Yuan Jin, Kai Xu, Xue Bai, Xiao-Zhou Liu, Xiao-Hui Wang, Sen Chen, Yu Sun

“…By use of 127 gene panel testing, more mutant genes and variants were identified. …”
Get full text

Detection and characterization of multidrug resistant Escherichia coli carrying virulence gene isolated from broilers in Bangladesh by Md. Sirazul Islam, Chandan Nath, F. M. Yasir Hasib, Tahia Ahmed Logno, Md. Helal Uddin, Mohammad Mahmudul Hassan, Sharmin Chowdhury

“…Objectives This study investigates the prevalence of Escherichia coli in broilers, their phenotypic antimicrobial resistance (AMR) profiles and the presence of virulence‐associated genes (VAGs) and antimicrobial resistance genes (ARGs) using polymerase chain reaction (PCR). …”
Get full text

The Potential Diagnostic Value of Immune-Related Genes in Interstitial Fibrosis and Tubular Atrophy after Kidney Transplantation by Bin Yang, Dike Shi, Yahong Chen, Yi Zhu

“…Raw data of IF/TA samples after kidney transplantation and control samples after kidney transplantation were extracted from the Gene Expression Omnibus (GEO) database (GSE76882 and GSE120495 datasets), and genes that were differentially expressed between the two groups (DEGs) were screened. …”
Get full text

New specific migraine prevention: monoclonal antibodies against calcitonin gene-related peptide and its receptor by K. Ryliškienė, D. Jatužis, A. Vaitkus

“…During the last decade, blocking calcitonin gene-related peptide (CGRP) has emerged as a possible mechanism for preventing migraine attacks, and monoclonal antibodies against CGRP and its receptor for the specific migraine prophylaxis have been developed. …”
Get full text

Weak genetic divergence and signals of adaptation obscured by high gene flow in an economically important aquaculture species by Bernarda Calla, Jingwei Song, Neil Thompson

Subjects: “…Gene flow…”
Get full text

Genome-wide identification of novel flagellar motility genes in Pseudomonas syringae pv. tomato DC3000 by Zichu Yang, Tyler Helmann, Maël Baudin, Maël Baudin, Maël Baudin, Karl J. Schreiber, Karl J. Schreiber, Zhongmeng Bao, Paul Stodghill, Paul Stodghill, Adam Deutschbauer, Adam Deutschbauer, Jennifer D. Lewis, Jennifer D. Lewis, Bryan Swingle, Bryan Swingle

Subjects: Get full text

Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning by D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider

“…Rare pathogenic variants in the LDLR gene are present in 75–85 % of cases with an identified molecular genetic cause of the disease, and variants in other genes (APOB, PCSK9, LDLRAP1, ABCG5, ABCG8, and others) occur at a frequency of &lt; 5 % in this group of patients. …”
Get full text

Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension by Kohei Kotani, Joji Kawabe, Hiroyasu Morikawa, Tomohiko Akahoshi, Makoto Hashizume, Susumu Shiomi

“…The functions of genes involved in idiopathic portal hypertension (IPH) remain unidentified. …”
Get full text

Predicting the Viscosity of Petroleum Emulsions Using Gene Expression Programming (GEP) and Response Surface Methodology (RSM) by Abubakar A. Umar, Ismail M. Saaid, Aliyu A. Sulaimon, Rashidah M. Pilus

“…The data obtained from the RSM analysis was used to develop a prediction model using gene expression programming (GEP). It was discovered that the viscosity of water has no effect on the viscosities of the studied emulsions, as does the water cut and amount of solids. …”
Get full text

Analysis of mutations in CDC27, CTBP2, HYDIN and KMT5A genes in carotid paragangliomas by E. N. Lukyanova, A. V. Snezhkina, D. V. Kalinin, A. V. Pokrovsky, A. L. Golovyuk, O. A. Stepanov, E. A. Pudova, G. S. Razmakhaev, M. V. Orlova, A. P. Polyakov, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva

“…Thus, there is a necessity to improve the methods for identification of cancer-asso ciated genes as well as pathogenic mutations.…”
Get full text