Impacts of plant root traits and microbial functional attributes on soil respiration components in the desert-oasis ecotone by Jinlong Wang, Jinlong Wang, Jinlong Wang, Guanghui Lv, Guanghui Lv, Guanghui Lv, Jianjun Yang, Jianjun Yang, Jianjun Yang, Xuemin He, Xuemin He, Xuemin He, Hengfang Wang, Hengfang Wang, Hengfang Wang, Wenjing Li, Wenjing Li, Wenjing Li

“…., taxonomic composition) and functional attributes (specifically, functional genes implicated in microbial carbon metabolism). …”
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A practical distribution pattern of α-SMA-positive carcinoma associated fibroblasts indicates poor prognosis of patients with pancreatic ductal adenocarcinoma by Bo Li, Meilong Shi, Yang Wang, Penghao Li, Xiaoyi Yin, Guoxiao Zhang, Xiaochao Kang, Huan Wang, Suizhi Gao, Kailian Zheng, Xiaohan Shi, Xiongfei Xu, Yukun Zhou, Hui Jiang, Wei Jing, Shiwei Guo, Gang Jin

“…RNA sequencing analysis revealed that the differentially expressed genes (DEGs) in Type I CAFs are closely associated with those in corresponding tumor tissues, highlighting the enhanced biological significance of immune-related and oncogenic invasive pathways.Conclusions Our findings that two types of α-SMA-positive CAFs with different spatial patterns present heterogeneously across tissues of PDACs and correlated with patients’ outcomes. …”
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Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regenera... by Zhaoyang Gong, Zhenhao Chen, Dachuan Li, Xiao Lu, Jianwei Wu, Hanqiu Sun, Ximeng Wang, Siyang Liu, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Chi Sun, Hongli Wang, Feng Zeng, Xiaosheng Ma

“…Notably, the composite significantly upregulated the expression of nerve growth-associated proteins, reduced inflammatory cytokines, scavenged reactive oxygen species (ROS), and promoted M2 macrophage polarization by inhibiting the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway. In a rat SCI model, it facilitated functional recovery and attenuated inflammation. …”
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Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury by Kurt T. K. Giuliani, Purba Nag, Benjamin C. Adams, Xiangju Wang, Seokchan Hong, Anca Grivei, Rebecca L. Johnston, Nicola Waddell, Kenneth K. C. Ho, Yilin Tian, Muhammad Ali Khan, Chang Seong Kim, Monica S. Y. Ng, Glenda Gobe, Jacobus P. J. Ungerer, Josephine M. Forbes, Helen G. Healy, Andrew J. Kassianos

“…Hypoxia+IL-1β-treated PTECs had 692 ‘unique’ differentially expressed genes (DEGs) compared to normoxic PTECs, with ‘cell cycle’ the most significantly enriched KEGG pathway based on ‘unique’ down-regulated DEGs (including CCNA2, CCNB1 and CCNB2). …”
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Early Subclinical Atherosclerosis in Gestational Diabetes: The Predictive Role of Routine Biomarkers and Nutrigenetic Variants by Marica Franzago, Federica Fraticelli, Marta Di Nicola, Francesco Bianco, Daniela Marchetti, Claudio Celentano, Marco Liberati, Raffaele De Caterina, Liborio Stuppia, Ester Vitacolonna

“…In a single blood sample, from each patient, we assessed 9 single nucleotide polymorphisms (SNPs) from 9 genes related to nutrients and metabolism, which were genotyped by High Resolution Melting analysis. …”
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Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems by Zsombor Szoke, Peter Fauszt, Maja Mikolas, Peter David, Emese Szilagyi-Tolnai, Georgina Pesti-Asboth, Judit Rita Homoki, Ildiko Kovacs-Forgacs, Ferenc Gal, Laszlo Stundl, Levente Czegledi, Aniko Stagel, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…Broiler exhibited higher abundances of key resistance genes, with tetracycline resistance predominantly associated with Bacteroides coprosuis, Pasteurella multocida, and Acinetobacter baumannii. …”
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Optimal dietary vitamin E level facilitates ovarian development of female largemouth bass (Micropterus salmoides) broodstock by Qiuyu Gao, Qiao Feng, Dong Zhou, Zhili Ding, Changle Qi, Youqin Kong, Qiyou Xu

“…Dietary vitamin E supplementation significantly upregulated the expression of genes involving vitamin E transfer, ovarian development, and hormone, including alpha-tocopherol transfer protein, luteinizing hormone, follicle-stimulating hormone, vitellogenin receptor (vgr), vitellogenin (vg), 17-beta-hydroxysteroid dehydrogenase (17β-hsd), cyclin-dependent kinase 2 (cdk2), and cytochrome P450 family 17 (cyp-17), with the highest expression levels detected in the 209.31 mg/kg group (P < 0.05). …”
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Integrative analyses of morpho-physiological, biochemical, and transcriptomic reveal the seedling growth response of Pinus yunnanensis to nitrogen and phosphorus fertilization by Junfei Xu, Junfei Xu, Xiyan Li, Shi Chen, Shi Chen, Lin Chen, Lin Chen, Junrong Tang, Junrong Tang, Peizhen Chen, Peizhen Chen, Nianhui Cai, Nianhui Cai, Yulan Xu, Yulan Xu

“…Additionally, the abundance of genes involved in cell division and proliferation, cellulose biosynthesis, and cell wall extension were dramatically upregulated, which potentially correlated with enhanced seedling growth. …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…CM272 exhibited potent antiproliferative activity in PDAC cell lines, inducing apoptosis and altering key metabolic and cell cycle-related genes. CM272 also enhanced chemotherapy sensitivity and significantly inhibited tumor growth in vivo without detectable toxicity. …”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Comparative analysis of differentially expressed genes in KEAP1 knockout cells versus controls, utilizing GO, KEGG, and Reactome pathway analyses, revealed substantial enrichment in pathways linked to extracellular matrix organization and cell adhesion processes. …”
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Molecular and Transmission Characteristics of Mycobacterium Tuberculosis Strains Among College Students in Beijing, China by Cao X, Li X, Song Z, He P, Zhang R, Teng C, Sun Q, Wang X, Zhao B, Zhang Z, Zhao Y

“…The results showed that about one-third (49/153) of the isolates carried one or more drug resistance genes, with more than half (26/49) associated with first-line anti-tuberculosis drugs. …”
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Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia by Olga Plisko, Jana Žodžika, Irina Jermakova, Inta Liepniece-Karele, Jeļena Eglīte, Dace Rezeberga

“…The local immune response, determined, among other factors, by Human Leucocyte Antigen (HLA) genes, is thought to be significant. Still the results of genome studies are inconsistent and differ between ethnical populations.  …”
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Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis by Manting Liu, Jiexiang Ye, Runtian Wu, Dongqiang Luo, Tao Huang, Dandan Dai, Kexin Wang, Yanping Du, Junwen Ou

“…ALP and Alizarin Red staining evaluated osteoblast differentiation and mineralization.ResultsNetwork pharmacology identified curcumin, berberine, and diosgenin as key active components of SBD, with the PI3K/Akt and VEGFR pathways as critical targets, and RAF1, FOXO3, and BRAF as hub genes. In vivo, SBD intervention significantly reduced bone structural damage and apoptosis, decreasing the rate of empty bone lacunae. …”
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Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer by Meng Ye, Guojie Xu, Liming Zhang, Zhihui Kong, Zhenhua Qiu

“…Therefore, understanding the role of folate and MTHFR genes in colorectal cancer may be helpful for potential preventive or therapeutic interventions. …”
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Cloned buffalo bulls and their somatic cell donor bulls exhibit similar in-vitro embryo production efficienc by Tanya Gupta, Gaurav Tripathi, Sonal Gupta, Naresh L. Selokar, Manoj Kumar Singh

“…Furthermore, the expression of pluripotency-related genes (OCT4, SOX2, and NANOG) was similar in blastocysts produced in both experimental groups. …”
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Biological Characteristics and Whole-Genome Analysis of a Porcine <i>E. coli</i> Phage by Shenghui Wan, Nana Li, Sajid Habib, Pei Zheng, Yanfang Li, Yan Liang, Yonggang Qu

“…No known resistance, lysogenic, or virulence-related genes were detected. The whole genome contains 55 open reading frames (ORFs). (4) Conclusions: This study isolated a bacteriophage that is capable of lysing multidrug-resistant <i>E. coli</i>. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…Q-PCR was used for the detection of the expression of Foxp3 and TLR2 genes in the lung. Western blot was used for the detection of the expression of TLR2, Gasdermin-D (GSDMD), IL-1α, and IL-1β in the lung. …”
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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

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Genomic strategies to facilitate breeding for increased β-Glucan content in oat (Avena sativa L.) by Sumandeep Kaur Bazzer, Guilherme Oliveira, Jason D. Fiedler, Raja Sekhar Nandety, Jean-Luc Jannink, Melanie Caffe

“…Comparison based on physical position showed that 12 out of 22 loci coincided with previously identified β-glucan QTLs, and three loci are in the vicinity of cellulose synthesis genes, Cellulose synthase-like (Csl). To perform a GWAS analysis across all breeding datasets, the β-glucan content of each breeding line was predicted for each of the 26 environments. …”
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Magnesium ions regulate the Warburg effect to promote the differentiation of enteric neural crest cells into neurons by Qiongqian Xu, Xixi He, Yaru Mou, Dong Sun, Xintao Zhang, Jichang Han, Xiaoyang Liu, Xingjian Liu, Xue Ren, Dongming Wang, Jian Wang, Chuncan Ma, Qiangye Zhang, Aiwu Li

“…Surface plasmon resonance was used to detect the binding affinity of magnesium ions with key glycolysis genes. The elastic modulus of the hydrogel was measured using a universal testing machine, while pore size and porosity were assessed with scanning electron microscopy. …”
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