Exploring the mechanism of Schisandra rubriflora in the treatment of polycystic ovary syndrome based on network pharmacology and molecular docking by Zhengyan Dou, Qingxian Li, Jing Zhang, Xin Zhang

“…Differentially expressed genes (DEGs) associated with PCOS were obtained by analyzing GSE54248 dataset. …”
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Optimizing chitosan derived from Metapenaeus affinis: a novel anti-biofilm agent against Pseudomonas aeruginosa by Anali Riahi, Hadideh Mabudi, Elahe Tajbakhsh, Laleh Roomiani, Hasan Momtaz

“…Moreover, chitosan treatment downregulated the RhlR and LasR genes in P. aeruginosa when compared to the control group (P < 0.05). …”
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Genome-wide identification and characterization of transcription factors involved in defense responses against Sclerotinia sclerotiorum in Brassica juncea by Xu Yang, Shaomin Guo, Hairun Jin, Jinze Zhang, Lijing Xiao, Qingjing Ouyang, Xu Long, Zhongbin Yan, Entang Tian

“…The expression of these three genes was validated in the double haploid lines of BC3 (the third backcrossing generation) derived from the HR×LR cross. …”
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Occurrence and Antimicrobial Resistance Pattern of Listeria monocytogenes Isolated From Bovine’s Milk and Meat in Mekelle City, Ethiopia by Tesfay Hailu, Getachew Gugsa, Yisehak Tsegaye, Meselu Ahmed, Nesibu Awol

“…Polymerase chain reaction (PCR) amplification of Iap, Imo0737, ORF2819, and ORF2110 genes was performed. In vitro antimicrobial susceptibility testing was performed using agar disk diffusion method. …”
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Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity by Ahmed Rakib, Mousumi Mandal, Md Abdullah Al Mamun, Sonia Kiran, Nelufar Yasmen, Lexiao Li, Daniel M. Collier, Jianxiong Jiang, Frank Park, Udai P. Singh

“…RNA-Seq analysis of AT immune cells isolated from mice fed a high-fat diet (HFD) versus normal fat diet (ND) identified a panel of genes that were markedly downregulated, including sialic acid-binding Ig-like lectin E (siglec-E), in HFD compared to ND mice.MethodsA series of experiments in wild-type (WT) and siglec-E knockout (siglec-E KO) mice was designed to investigate the effect of HFD on the functional role of siglec-E in the regulation of AT inflammation and adipogenesis. …”
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Autism spectrum disorder: definition, global epidemiology, prevalence in Poland and worldwide, and heredity by Martyna Zakrocka, Marta Gruszka, Paulina Polańska, Maria Kubicka

“…While its exact causes remain unknown, ASD risk is influenced by genetic, environmental, prenatal, and perinatal factors, with genes like SHANK3, CHD8, and FMR1 playing key roles. …”
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Contribution of OqxAB Efflux Pump in Selection of Fluoroquinolone-Resistant Klebsiella pneumoniae by Orsolya Szabo, Bela Kocsis, Nikolett Szabo, Katalin Kristof, Dora Szabo

“…Mutation in gyrA and parC genes was analyzed in each strain and multilocus sequence typing (MLST) was performed. …”
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Modern issues of sugar beet (<i>Beta vulgaris</i> L.) hybrid breeding by S. D. Karakotov, I. V. Apasov, A. A. Nalbandyan, E. N. Vasilchenko, T. P. Fedulova

“…Testing of the OP-S4 marker’s being in the same linkage group as the genes responsible for expression of the economically valuable trait monogermity demonstrates its relative reliability. …”
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Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition. by Tiffany M Halvorsen, Kaitlin A Schroeder, Allison M Jones, Disa Hammarlöf, David A Low, Sanna Koskiniemi, Christopher S Hayes

“…Group 5 exploits homologous putrescine import proteins encoded by puuP and plaP, and group 6 toxins recognize di/tripeptide transporters encoded by paralogous dtpA and dtpB genes. Finally, we find that the ionophore domains exhibit significant intra-group sequence variation, particularly at positions that are predicted to interact with CdiI. …”
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Detection of mutations in plasma cell-free DNA of colorectal cancer patients and comparison with cancer panel data for tissue samples of the same cancers by Suji Min, Sun Shin, Yeun-Jun Chung

“…We first examined the genetic alteration profiles of three colorectal cancer (CRC) tissue samples by targeted next-generation sequencing (NGS) and identified 11 non-silent amino acid changes across six cancer-related genes (APC, KRAS, TP53, TERT, ARIDIA, and BRCA1). …”
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Avian colibacillosis – current aspects by A. O. Gerasimova, O. B. Novikova, A. A. Savicheva

“…The disease spread is closely associated with antibiotic resistance problem because a diseased carrier bird may be a reservoir of antibiotic-resistant Escherichia coli strains. In addition, genes of virulence and resistance have been proven to be transferred from avian Escherichia strains toextra intestinal pathogenic strains that are dangerous to humans. …”
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Sample Size and Statistical Power Calculation in Genetic Association Studies by Eun Pyo Hong, Ji Wan Park

“…A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger sample sizes to achieve an adequate statistical power. …”
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NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB by Hongchu Bao, Qinglan Qu, Wei Zhang, Xinrong Wang, Jianye Fang, Jinwen Xue, Zhenteng Liu, Shunzhi He

“…Immunoprecipitation experiments showed that NRF2 directly binds to p65 in the nucleus and inhibits the binding of p65 to downstream target genes (TNF-α, IL-1β, IL-6, and IL-8). Even though a NF-κB/p65 inhibitor (PDTC) reduced the LPS-induced NRF2 expression and nuclear abundance of NRF2, overexpressing TNF-α reversed the inhibitory effects of PDTC on the NRF2 expression and on its abundance in the nucleus. …”
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Single-Cell Analyses Reveal Necroptosis’s Potential Role in Neuron Degeneration and Show Enhanced Neuron-Immune Cell Interaction in Parkinson’s Disease Progression by Xiaomei Zeng, Zhifen Han, Kehan Chen, Peng Zeng, Yidan Tang, Lijuan Li

“…Our bioinformatics analyses revealed necroptosis-related genes (NRGs) enrichment in neuron degeneration and selecting the cells by NRGs levels showed two subtypes within the main degenerative cell types in the midbrain. …”
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Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis. by Shruthi Bandyadka, Diane P V Lebo, Albert A Mondragon, Sandy B Serizier, Julian Kwan, Jeanne S Peterson, Alexandra Y Chasse, Victoria K Jenkins, Anoush Calikyan, Anthony J Ortega, Joshua D Campbell, Andrew Emili, Kimberly McCall

“…In this report, we describe the genes and major pathways identified in the screens and the striking consequences to Drosophila melanogaster oogenesis caused by RNAi perturbation of prioritized candidates. …”
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Studying the impact of chitosan salicylaldehyde/schiff base/CuFe2O4 in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling by Ghada H. Elsayed, Asmaa M. Fahim

“…The mRNA expression levels of PI3K, AKT, mTOR, and CCND1 were examined in PC3-treated cells by using QRT-PCR, and the results demonstrated that, by down-regulating the expression levels of these genes, chitosan salicylaldehyde/CuFe2O4 significantly affected prostate cancer cell proliferation, progression, and autophagy more than chitosan salicylaldehyde. …”
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Identification and functional characterization of the MYB transcription factor GmMYBLJ in soybean leaf senescence by Guohua Bao, Xiao Xu, Jing Yang, Juanjuan Liu, Tianran Shi, Xiaoxuan Zhao, Xuyan Li, Shaomin Bian

“…Ectopic overexpression of GmMYBLJ in Arabidopsis not only led to earlier leaf senescence, reduced chlorophyll content, and increased MDA accumulation but also promoted the expression of several WRKY family transcription factors and senescence-associated genes, such as SAG12 and ORE1. Further investigation showed that overexpression of GmMYBLJ accelerated Arabidopsis leaf senescence under darkness and in response to Pst DC3000 infection. …”
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Effect of Cd–Zn compound contamination on the physiological response of broad bean and aphids by Liya Chen, Sijing Wan, Qintian Shen, Keting Zhao, Yanlan He, Yexin Xie, Shiyu Tao, Shuchang Zheng, Yi Zhang, Shigui Wang, Bin Tang, Yan Li, Yan Li

“…In addition, in the first generation of adult aphids, treatment with Cd (12.5 mg/kg) + Zn (100 mg/kg) significantly affected the expression of trehalase (TRE) and trehalose-6-phosphate synthase (TPS) genes and influenced the carbohydrate content and trehalase activity in the aphids.DiscussionThe number of offspring produced by the second-generation aphids was significantly reduced under mixed heavy metal treatment, but it was not caused by changes in the vitellogenin (Vg) content. …”
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Regulation of Pear Fruit Quality: A Review Based on Chinese Pear Varieties by Ying Zhang, Yudou Cheng, Yuru Ma, Junfeng Guan, Hao Zhang

“…Over the past decade, significant progress has been made in understanding the formation and regulatory mechanisms of fruit quality, with numerous key functional genes associated with quality traits being identified. …”
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Ningxiang pig-derived lactobacillus reuteri modulates host intramuscular fat deposition via branched-chain amino acid metabolism by Mei Yang, Qian Xie, Jing Wang, Andong Zha, Jiashun Chen, Qian Jiang, Meng Kang, Qiuchun Deng, Yulong Yin, Bie Tan

“…Additionally, it has been verified that L. reuteri originating from NX pigs has the ability to improve BCAA synthesis in the gut and enhance IMF content in lean DLY pigs. The expression of genes related to lipid synthesis was also significantly upregulated. …”
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