miR-21 Overexpression Promotes Esophageal Squamous Cell Carcinoma Invasion and Migration by Repressing Tropomyosin 1 by Zhuojian Shen, Xia Xu, Liangzhan Lv, Honglue Dai, Ju Chen, Baishen Chen

Get full text

Exploring the comorbidity mechanisms between atherosclerosis and hashimoto’s thyroiditis based on microarray and single-cell sequencing analysis by Yirong Ma, Shuguang Wu, Junyu Lai, Qiang Wan, Jingxuan Hu, Yanhong Liu, Ziyi Zhou, Jianguang Wu

“…We elucidated gene functions and regulatory networks across various biological scenarios through enrichment and pathway analysis using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). …”
Get full text

Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus by Tam Duong, Michele Firmo, Chien-Ting Li, Bingnan Gu, Peng Wang

“…Abstract Recombinant adeno-associated virus (rAAV) has emerged as the vector of choice for in vivo gene delivery, with numerous clinical trials underway for the treatment of various human diseases. …”
Get full text

Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer by Seungyeul Yoo, Ayushi S. Patel, Sarah Karam, Yi Zhong, Li Wang, Feng Jiang, Ranran Kong, Sharon Bikvan, Wenhui Wang, Abhilasha Sinha, Charles A. Powell, Jun Zhu, Hideo Watanabe

“…GRN and its associated genes were linked to cancer cell intrinsic immunogenicity, and single-cell RNA-seq data revealed that GRN expression is particularly high in subsets of tumor-associated macrophages. …”
Get full text

Risk of Atherosclerosis and Helicobacter pylori Infection according to CD14 Promotor Polymorphism in Healthy Korean Population by Sung-Goo Kang, Woo Chul Chung, Sang-Wook Song, Kyu Re Joo, Hyewon Lee, Donghoon Kang, Joune Seup Lee, Kang-Moon Lee

“…The promotor polymorphism at −159C/T of the CD14 gene was determined by PCR-restriction fragment length polymorphism analysis. …”
Get full text

Effect of amisulpride on the expression of serotonin receptors, neurotrophic factor BDNF and its receptors in mice with overexpression of the aggregation-prone [R406W] mutant tau p... by E. M. Kondaurova, A. A. Komarova, T. V. Ilchibaeva, A. Ya. Rodnyy, E. A. Zalivina, V. S. Naumenko

“…In these animals we examined short-term memory and the expression of genes involved in the development of tauopathy (Htr7 and Cdk5), as well as biomarkers of neurodegenerative processes – the Bdnf gene and its receptors TrkB (the Ntrk2 gene) and p75NTR (the Ngfr gene). …”
Get full text

Decreased Spp1 Expression in Acute Myocardial Infarction after Ischemia and Reperfusion Injury by Ling Li, Jungang Huang, Zongkai Zhao, Zhuzhi Wen, Kang Li, Tianjiao Ma, Lisui Zhang, Junmeng Zheng, Shi Liang

“…Besides, Gene Set Enrichment Analysis (GSEA), a tool to find the pathway orientation of a gene set, was used for further study in the four most significant KEGG pathways. …”
Get full text

Genome evolution following an ecological shift in nectar-dwelling Acinetobacter by Vivianna A. Sanchez, Tanya Renner, Lydia J. Baker, Tory A. Hendry

“…Gene gains appear to result from duplication events, evolutionary divergence, and horizontal gene transfer. …”
Get full text

De Novo Assembly of the Pea (Pisum sativum L.) Nodule Transcriptome by Vladimir A. Zhukov, Alexander I. Zhernakov, Olga A. Kulaeva, Nikita I. Ershov, Alexey Y. Borisov, Igor A. Tikhonovich

“…The large size and complexity of the garden pea (Pisum sativum L.) genome hamper its sequencing and the discovery of pea gene resources. Although transcriptome sequencing provides extensive information about expressed genes, some tissue-specific transcripts can only be identified from particular organs under appropriate conditions. …”
Get full text

Sex Differences in the Allele Distribution of PGLYRP2 Variant rs892145 in Parkinson’s Disease by Caroline Ran, Karin Wirdefeldt, Olof Sydow, Per Svenningsson, Rochellys Diaz Heijtz

“…Parkinson’s disease (PD) is a complex multifactorial disease, involving genetic susceptibility, environmental risk factors, and gene-environmental interactions. The microbiota-gut-brain axis is hypothesized to play a role in the pathophysiology of PD, and peptidoglycan recognition proteins (PGLYRPs), which modulate the gut microbiota, are, therefore, relevant candidate genes for PD. …”
Get full text

Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…In the first the liver of laboratory animals is the main pathogenic target, metabolic disorders develop insignificantly (lines of animals with of Acetyl-CoA oxidase gene deletion, knockoutmice for methionine-adenosyl transferases-1А gene and animals with deleted specific hepatic phosphatase and tensin homologue gene). …”
Get full text

Identification of mitophagy-related biomarkers and immune infiltration in polycystic ovarian syndrome by bioinformatic study by Hongjuan Ye, Xicheng Wang, Zhiying He

“…Methods: Training datasets were used for differential expression genes. Gene ontology annotations and Kyoto encyclopedia of genes and genomes signaling pathway enrichment analysis were performed. …”
Get full text

Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A) by A. Essadik, H. Jouhadi, T. Rhouda, S. Nadifiyine, A. Kettani, F. Maachi

“…Polymorphisms in tumor necrosis factor alpha (TNF-α) gene are emerging as key determinants of gastric diseases. …”
Get full text

Molecular network analysis for detecting HIV transmission clusters: insights and implications by Yangyang Liu, Lichun Hua, Wenqian Wu, You Ge, Wei Li, Pingmin Wei

“…HYPHY and Cytoscape were used to generate and illustrate molecular networks.ResultsIn this investigation of 89 double-positive pairs, it was discovered that the pairwise gene distance approach properly detected 82.02% of positive couples at an ideal gene distance of 0.014 substitution/loci. …”
Get full text

The 256 kb mitochondrial genome of Clavaria fumosa is the largest among phylum Basidiomycota and is rich in introns and intronic ORFs by Xu Wang, Yajie Wang, Wen Yao, Jinwen Shen, Mingyue Chen, Ming Gao, Jiening Ren, Qiang Li, Na Liu

“…In addition, the rps3 gene was found subjected to positive selection between some Agaricales species. …”
Get full text

Meta-analysis of microarray and RNAseq data reveal OsbZIP52 to mediate salt stress responses in sensitive, tolerant and halophyte rice varieties by Dipankor Chatterjee, Mohammad Umer Sharif Shohan, Nishat Tamanna, Zeba I. Seraj

“…Such genes can be used to find prospective candidate salt resistance genes in donor rice genotypes and transfer them to high-yielding rice varieties. …”
Get full text

Analysis of Genetic Diversity and Relationships of Local Walnut Populations in the Western Caspian Region of the North Caucasus by Ivan Suprun, Ilya Stepanov, Dzhalaludin Anatov

“…Presumably, the structure of the gene pool could have been influenced by terrain factors and ethnocultural characteristics. …”
Get full text

Transcriptome atlases of rat brain regions and their adaptation to diabetes resolution following gastrectomy in the Goto-Kakizaki rat by François Brial, Aurélie Le Lay, Claude Rouch, Edouard Henrion, Mathieu Bourgey, Guillaume Bourque, Mark Lathrop, Christophe Magnan, Dominique Gauguier

“…Abstract Brain regions drive multiple physiological functions through specific gene expression patterns that adapt to environmental influences, drug treatments and disease conditions. …”
Get full text

Identification of Potential Biomarkers for Coronary Artery Disease Based on Cuproptosis by Bohong Zhang, Mingliang He

“…Currently, no studies have been published about the effects of cuproptosis-related genes (CRGs) on diagnosing CAD. To screen marker genes for CAD from CRGs, we downloaded the whole blood cell gene expression profile of CAD patients and normal samples, i.e., the GSE20680 dataset, from the GEO database. …”
Get full text

Physical exercise improves the premature muscle aging and lifespan reduction induced by high-salt intake and muscle CG2196(salt) overexpression in Drosophila by Dengtai Wen, Yiling Chen, Xu Tian, Wenqi Hou

“…In this study, the flies were fed a high-salt diet and trained to exercise. Muscle CG2196 (salt) gene and dSir2 gene were over-expressed by building mef2-gal4/UAS system. …”
Get full text