The Class III Peroxidase gene TaPRX-2A controls grain number per spike in common wheat (Triticum aestivum L.) by Dongtian Zang, Wenjia You, Yangyang Wu, Pengyue Wang, Zhiyu Wang, Qingyun Yang, Shatong Chi, Peisen Su, Peisen Su

“…In our study, we cloned a wheat PRX gene TaPRX-2A and identified its function in controlling GNS by generating transgenic overexpression lines. …”
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Integrative analysis of metabolite and transcriptome reveals the biosynthetic pathway and candidate genes for iridoid glycoside biosynthesis in Neopicrorhiza scrophulariiflora (Pennell) D.Y.Hong by Ke Rao, Ke Rao, Siyu Liu, Siyu Liu, Xiaohui Tang, Guofu Jia, Shaohua Yang, Chaoxiang Ren, Chaoxiang Ren, Jin Pei, Jin Pei

“…Through qRT-PCR validation, we found that three NsF3H/NsF3D genes, four NsUGD/NsUPD genes, one Ns2HFD gene, and three NsSQM genes may participate in the iridoid biosynthesis pathway. …”
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Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men by Pedro Fernandez, Charnita M. Zeigler-Johnson, Elaine Spangler, André van der Merwe, Mohamed Jalloh, Serigne M. Gueye, Timothy R. Rebbeck

“…Metastasis occurred more frequently in Senegalese men. Gene polymorphism frequencies differed significantly between South African and Senegalese men. …”
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Effect of 25-hydroxycholecalciferol and high phytase doses on performance, vitamin D status, bone mineralization, and mechanistic target of rapamycin gene expression of broilers by L.S. Bassi, C.C.S. Martins, C.A. Lozano-Poveda, I.C. Dias, S.G. Oliveira, A. Maiorka

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Retraction: The two-component system CpxR/A represses the expression of Salmonella virulence genes by affecting the stability of the transcriptional regulator HilD by Frontiers Editorial Office

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Effect of NAM-1 genes on the protein content in grain and productivity indices in common wheat lines with foreign genetic material introgressions in the conditions of Belarus by O. A. Orlovskaya, S. I. Vakula, K. K. Yatsevich, L. V. Khotyleva, A. V. Kilchevsky

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Genetic diversity of potato varieties bred in Russia and near-abroad countries based on polymorphism of SSR-loci and markers associated with resistance R-genes by O. Y. Antonova, N. A. Shvachko, L. Y. Novikova, O. Y. Shuvalov, L. I. Kostina, N. S. Klimenko, A. R. Shuvalova, T. A. Gavrilenko

“…In the molecular screening of potato varieties, it is better to use several markers of these genes. Results of molecular screening using six markers of the H1 and Gro1-4 genes allowed us to detect 6 haplotypes in the tested subset. …”
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Whole-Genome Duplication and Purifying Selection Contributes to the Functional Redundancy of Auxin Response Factor (ARF) Genes in Foxtail Millet (Setaria italica L.) by You Chen, Bin Liu, Yujun Zhao, Wenzhe Yu, Weina Si

“…Auxin response factors (ARFs) play crucial roles in auxin-mediated response, whereas molecular genetics of ARF genes was seldom investigated in Setaria italica, an important crop and C4 model plant. …”
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An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model by Michael P. Leviton, Juan C. Lacayo, K. Yeon Choi, Nelmary Hernandez-Alvarado, Andrew Wey, Mark R. Schleiss

“…Development of a vaccine against congenital cytomegalovirus (CMV) infection is a public health priority, but CMVs encode immune evasion genes that complicate live virus vaccine design. …”
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Ensemble Methods with Voting Protocols Exhibit Superior Performance for Predicting Cancer Clinical Endpoints and Providing More Complete Coverage of Disease-Related Genes by Runyu Jing, Yu Liang, Yi Ran, Shengzhong Feng, Yanjie Wei, Li He

“…In genetic data modeling, the use of a limited number of samples for modeling and predicting, especially well below the attribute number, is difficult due to the enormous number of genes detected by a sequencing platform. In addition, many studies commonly use machine learning methods to evaluate genetic datasets to identify potential disease-related genes and drug targets, but to the best of our knowledge, the information associated with the selected gene set was not thoroughly elucidated in previous studies. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Bcl-2 (B-cell lymphoma 2), encoded by the human Bcl-2 gene, is a critical anti-apoptotic protein that regulates cell death pathways, primarily by inhibiting apoptosis. …”
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BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia by Xu Sang, Yongping Zhang, Fang Fang, Li Gao, Yanfang Tao, Xiaolu Li, Zimu Zhang, Jianwei Wang, Yuanyuan Tian, Zhiheng Li, Di Yao, Yumeng Wu, Xinran Chu, Kunlong Zhang, Li Ma, Lihui Lu, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Zhen Zhang, Jian Pan, Shaoyan Hu

“…Based on analysis of RNA-seq and ChIP-seq analyses, GNE-987 could target multiple SE- (super-enhancer-) related genes, including LYL1 (lymphoblastic leukemia 1), to inhibit AML. …”
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The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment by Yanchao Luan, Chao Liang, Qingsong Han, Xueqin Zhou, Na Yang, li Zhao

“…Methods For the purpose of identifying butyrate metabolism-related differentially expressed genes (BMR-DEGs) in the TCGA-LUAD dataset, we introduced transcriptome data. …”
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Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells by Ilaria Lampronti, Maria Giulia Manzione, Gianni Sacchetti, Davide Ferrari, Susanna Spisani, Valentino Bezzerri, Alessia Finotti, Monica Borgatti, Maria Cristina Dechecchi, Giorgia Miolo, Giovanni Marzaro, Giulio Cabrini, Roberto Gambari, Adriana Chilin

“…In this biological system, NF-κB-mediated IL-8 gene expression was investigated. Some analogues showed similar activity to the lead compound TMA. …”
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miR-146a expression and the miR-146a gene variant rs2910164 as diagnostic and prognostic biomarkers of oral cancer by Vuković Miodrag, Stojković Goran, Zeljić Katarina

“…This study aimed to analyze the diagnostic and prognostic significance of miR-146a-5p in oral cancer and the association of the rs2910164 gene variant with miR-146a-5p expression. Thirty-five oral cancer patients participated in the study. …”
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CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production by Emily E. O’Driscoll, Sakshi Arora, Jonathan F. Lang, Beverly L. Davidson, Ophir Shalem

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ALLELIC DIVERSITY OF THE <i> Ppd </i> AND <i> VRN </i> GENES INVOLVED IN CONTROL OF THE DURATION OF SHOOTING-EARING STAGE IN DAGESTANIAN BARLEY ACCESSIONS by R. A. Abdullaev, N. V. Alpatieva, Yu. I. Karabitsina, I. A. Zveinek, B. A. Batasheva, I. N. Anisimova, E. E. Radchenko

“…In 207 barley accessions the dominant and recessive alleles of the Ppd and VRN genes involved in control of the period between shooting and earing stages were identified with the use of allele-specific molecular markers. …”
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INNA N. GOLUBOVSKAYA AS THE FOUNDER OF A UNIQUE COLLECTION OF MEIOTIC GENE MUTATIONS IN MAIZE AND A TALENTED RESEARCHER OF THE PROBLEM OF MEIOSIS GENETIC CONTROL by Yu. F. Bogdanov

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IDENTIICATION OF THE Lr34 GENE FOR RESISTANCE TO LEAF RUST IN VARIETIES AND COLLECTION SAMPLES OF WINTER SOFT WHEAT FROM THE AGRICULTURAL RESEARCH CENTER “DONSKOY” by N. N. Vozhzhova

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Role of Prothrombin and Methylenetetrahydrofolate Reductase Gene Polymorphisms as well as Thrombophilia Markers, as Risk Factors for Unexplained Recurrent Miscarriage: A Case-Control Study by Zeinab Ahmed Abd Elhameed, Omar M Shaaban, Hanan G Abd Elazeem, Azza Abouelfadle, Tarek Farghaly, Ghada Mahran, Mohamed Ismail Seddik

“…Inheritedthrombophilias have been one of the causes. Mutation in genes encoding coagulation proteins, including prothrombin(PT G20210A) and methylenetetrahydrofolate reductase (MTHFR) genes, increase tendency for venous thromboembolism.This study aimed to evaluate association between polymorphisms in prothrombine and MTHFR genes withRM. …”
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