The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis by Haitao Mei, Qingshan Luo, Junyong Weng, Jialing Hao, Jinfeng Cai, Runkai Zhou, Ce Bian, Yingzi Ye, Shengzheng Luo, Yugang Wen

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A multi-stage deep learning network toward multi-classification of polyps in colorectal images by Shilong Chang, Kun Yang, Yucheng Wang, Yufeng Sun, Chaoyi Qi, Wenlong Fan, Ying Zhang, Shuang Liu, Wenshan Gao, Jie Meng, Linyan Xue

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Systematic identification of secondary bile acid production genes in global microbiome by Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao

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A pilot randomized controlled trial of the iPeer2Peer program in adolescents with sickle cell disease: A mixed method study by Lauren Kelenc, Brittany Wiles, Fareha Nishat, Chitra Lalloo, Anya Nair, Craig Eling, Melanie Kirby-Allen, Ewurabena Simpson, Roona Sinha, Richard Ward, William T. Zempsky, Sara Ahola Kohut, Jennifer N. Stinson

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Laparoscopic excision of deep rectovaginal endometriosis in BSGE endometriosis centres: a multicentre prospective cohort study by Paul Smith, Lucky Saraswat, Sanjay Vyas, Thomas Ind, Ertan Saridogan, Elizabeth Ball, Edward Morris, James Clark, Tony Chalhoub, David Rowlands, Moiad Alazzam, Dominic Byrne, Tamara Curnow, Alfred Cutner, T Justin Clark, Iris Menninger, Yousri Afifi, Kevin Phillips, Saikat Banerjee, Robert Richardson, Jeremy Hawe, Barry Whitlow, Emmanuel Ofuasia, Ashwini Trehan, Tyrone Carpenter, Christian Becker, Stuart Jack, Kumar Kunde, Chris Barnick, Alan Farthing, Graham Phillips, John Bidmead, Mohamed Abdel-aty, George Botros, Marlin Mubarak, Christian Kremer, Stanley Okolo, Edmond Edi-osagi, Kamel Shehata-iskander, Gaity Ahmad, Jonathan Frappell, Brice Rodriguez, Yemi Coker, Gourab Misra, Adam Moors, Chris Guyer, Caroline Overton, Suku George, Oliver Chappatte, Richard Penketh, Funlayo Odejinmi, Keith Louden, Jon Hughes

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Unveiling causal immune cell–gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses by Hui Zhang, Hui Zhang, Ling Zhang, Jing-Xuan Lian, Zhi-Fu Kou, Yu Zhu, Yu Zhu, Li-Tian Ma, Li-Tian Ma, Jin Zheng, Jin Zheng, Can-Jun Zhao, Can-Jun Zhao

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Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro... by Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye

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Predictors of Colorectal Cancer Screening and Screening Modalities among Patients seen at Federally Qualified Health Centers Funded by the United States Health Resources and Servic... by Megan R.M. Aaronson, Nadereh Pourat, Connie Lu, Jayraan Badiee, Helen Yu-Lefler, Benjamin Picillo, Hank Hoang, Folasade P. May

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Impact of Population-Based Screening for Diabetes and Prediabetes Among 67-Year-Olds Using Point-of-Care HbA1c on Healthcare Ultilisation, Results from the VISP Cohort by Andersen JW, Høgh A, Lindholt JS, Søgaard R, Støvring H, Yderstræde KB, Sandbæk A, Dahl M

“…Jesper Winkler Andersen,1,2 Annette Høgh,1,3 Jes Sanddal Lindholt,1,3– 6 Rikke Søgaard,5 Henrik Støvring,3,7 Knud Bonnet Yderstræde,5,8 Annelli Sandbæk,9– 11 Marie Dahl1,3– 5 1Vascular Research Unit, Department of Vascular Surgery, Viborg Regional Hospital, Viborg, Denmark; 2Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; 3Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 4Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark; 5Department of Clinical Research, University of Southern Denmark, Odense, Denmark; 6Elite Centre of Individualized Treatment of Arterial Diseases (CIMA), Odense University Hospital, Odense, Denmark; 7Department of Biomedicine, Aarhus University, Aarhus, Denmark; 8Diabetes Center, Steno, Odense, Denmark; 9Department of Public Health, Aarhus University, Aarhus, Denmark; 10Research unit of General Medical Practice, Aarhus University, Aarhus, Denmark; 11Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, DenmarkCorrespondence: Jesper Winkler Andersen, Vascular Research Unit, Department of Surgery, Viborg Regional Hospital, Toldbodgade 12, Viborg, 8800, Denmark, Tel +45 28118736, Email jesper.andersen@midt.rm.dkPurpose: The present study aims to evaluate the changes in healthcare utilization following population-based screening for diabetes mellitus (DM) using point-of-care HbA1c measurement in the Viborg Screening Program (VISP) cohort, which invites all 67-year-olds in Viborg, Denmark, for cardiovascular disease (CVD) and DM screening.Patients and Methods: We conducted a cohort study using data from VISP and Danish national health registers. …”
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A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction by Gwyneth Kong, Jaycie Koh, Jobelle Chia, Bryan Neo, Yiming Chen, Grace Cao, Bryan Chong, Mark Muthiah, Hui Wen Sim, Gavin Ng, Chieh Yang Koo, Chin Meng Khoo, Mark Yan-Yee Chan, Poay-Huan Loh, Nicholas W. S. Chew

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Machine-Learning Parsimonious Prediction Model for Diagnostic Screening of Severe Hematological Adverse Events in Cancer Patients Treated with PD-1/PD-L1 Inhibitors: Retrospective... by Seok Jun Park, Seungwon Yang, Suhyun Lee, Sung Hwan Joo, Taemin Park, Dong Hyun Kim, Hyeonji Kim, Soyun Park, Jung-Tae Kim, Won Gun Kwack, Sung Wook Kang, Yun-Kyoung Song, Jae Myung Cha, Sang Youl Rhee, Eun Kyoung Chung

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LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

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The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast... by Andrea Vittorio Emanuele Lisa, Marzia Salgarello, Alessandra Huscher, Fabio Corsi, Daniele Piovani, Federica Rubbino, Stefania Andreoletti, Giovanni Papa, Francesco Klinger, Corrado Tinterri, Alberto Testori, Marta Scorsetti, Paolo Veronesi, Maria Cristina Leonardi, Mario Rietjens, Umberto Cortinovis, Valeria Summo, Emanuele Rampino Cordaro, Pier Camillo Parodi, Paolo Persichetti, Mauro Barone, Giorgio De Santis, Matteo Murolo, Michele Riccio, Angelica Aquinati, Francesco Cavaliere, Nicola Vaia, Giulia Pagura, Erica Dalla Venezia, Franco Bassetto, Vincenzo Vindigni, Luigi Ciuffreda, Maria Alessandra Bocchiotti, Alberto Sciarillo, Nadia Renzi, Graziano Meneghini, Tajna Kraljic, Andrea Loreti, Lucio Fortunato, Valentina Pino, Valeriano Vinci, Marco Klinger

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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

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Nucleus-translocated GCLM promotes chemoresistance in colorectal cancer through a moonlighting function by Jin-Fei Lin, Ze-Xian Liu, Dong-Liang Chen, Ren-Ze Huang, Fen Cao, Kai Yu, Ting Li, Hai-Yu Mo, Hui Sheng, Zhi-Bing Liang, Kun Liao, Yi Han, Shan-Shan Li, Zhao-Lei Zeng, Song Gao, Huai-Qiang Ju, Rui-Hua Xu

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Aurora kinase A promotes hepatic stellate cell activation and liver fibrosis through the Wnt/β-catenin pathway by Guanqi Dai, Guanqi Dai, Junhao Lin, Yuchuan Jiang, Yuchuan Jiang, Xinhui Liu, Peng Chen, Yixiao Zhang, Zhenghui Song, Xuefen Zhuang, Jinge Cong, Yingchun Li, Xuanjia Hong, Yun Liu, Dong Xiao, Dong Xiao, Aimin Li, Yue Luo

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Five-Year Prospective Follow-Up of Patients with Hepatitis C Virus Infection Treated with Direct-Acting Antiviral Agents by Zhang Y, Xia H, Fan L, Jiang L, Yang B, Wang F

“…Yaping Zhang,1,2,* Huan Xia,3,* Luchang Fan,1 Lu Jiang,4 Bin Yang,2 Fengmei Wang4,5 1The Third Central Clinical College of Tianjin Medical University, Tianjin Medical University, Tianjin, 300170, People’s Republic of China; 2Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Nankai University Affiliated Third Central Hospital, Tianjin, 300072, People’s Republic of China; 3Department of Infectious Diseases, Tianjin Second People’s Hospital, Tianjin, 300192, People’s Republic of China; 4Department of Hepatology and Gastroenterology, Tianjin First Central Hospital, Tianjin, 300192, People’s Republic of China; 5Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer, Tianjin First Central Hospitial, Tianjin, 300192, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fengmei Wang; Bin Yang, Email wangfengmeitj@126.com; bioyang@126.comPurpose: The research intended to present prospective data on the long-term prognosis of individuals with hepatitis C virus (HCV) infection who received direct-acting antiviral agent (DAA) treatment.Patients and Methods: Patients who received DAA treatment at Tianjin Third Central Hospital and Tianjin Second People’s Hospital were prospectively enrolled and subsequently underwent a longitudinal follow-up. …”
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Significance of supervision sampling in control of communicable respiratory disease simulated by a new model during different stages of the disease by Alphonse Houssou Hounye, Xiaogao Pan, Yuqi Zhao, Cong Cao, Jiaoju Wang, Abidi Mimi Venunye, Li Xiong, Xiangping Chai, Muzhou Hou

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NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

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Risk and Prognosis of Hepatocellular Carcinoma in Mexican Americans with Type 2 Diabetes Mellitus by Hatia RI, Hwang LY, Li R, Troisi C, Jalal PK, Amos CI, Gomez HF, Chun YS, Rashid A, Kaseb AO, Scheet PA, Hassan MM

“…Rikita I Hatia,1 Lu-Yu Hwang,2 Ruosha Li,3 Catherine Troisi,4 Prasun K Jalal,5 Christopher I Amos,6 Henry F Gomez,1 Yun Shin Chun,7 Asif Rashid,8 Ahmed O Kaseb,9 Paul A Scheet,1 Manal M Hassan1 1Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA; 3Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA; 4Department of Management, Policy & Community Health, School of Public Health, The University of Health Science Center at Houston, Houston, TX, USA; 5Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX, USA; 6Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA; 7Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 8Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 9Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Manal M Hassan, Department of Epidemiology, Unit 735, The University of Texas MD Anderson Cancer Center, 6900 Fannin Street, Houston, TX, 77030, USA, Tel +1-713-794-5452, Email mhassan@mdanderson.org Lu-Yu Hwang, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Pressler Street, RAS E717, Houston, TX, 77030, USA, Tel +1-713-500-9384, Email lu-yu.hwang@uth.tmc.eduIntroduction: Hepatocellular carcinoma (HCC) disproportionately affects Hispanic persons with higher age-specific incidence and increased mortality rates compared to non-Hispanic Whites. …”
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