Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates. by Athos Silva De Oliveira, Leroy Versteeg, Neima Briggs, Rakesh Adhikari, Maria Jose Villar, JeAnna R Redd, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet

“…<h4>Conclusions/significance</h4>These findings emphasize the importance of antigen localization in tailoring immune responses and suggest that extracellular antigens are more effective for inducing humoral responses, whereas cytosolic antigen accumulation enhances MHC-1 peptide presentation. Future studies will determine if these in vitro and immunogenicity findings translate to in vivo efficacy. …”
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Mortality and patient disposition after ICU tracheostomy for secretion management vs. prolonged ventilation: a retrospective cohort study by Dominique Dundaru-Bandi, Linda M. Zhu, Milana Schipper, Paul J. Warshawsky, Blair C. Schwartz

“…Patient-centered outcomes should be included in future studies and if confirmed, these outcomes should be incorporated into discussions about tracheostomy decision making.…”
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A Bibliometric Analysis of Macrophage Research Associated with Periodontitis Over the Past Two Decades by Yu Qiu, Zhenzhen Ding, Deqin Yang

“…Research on macrophages in periodontitis is progressing quickly, and their strategic targeting offers a new and promising direction for future studies on regenerating periodontal tissues. The utilization of extracellular vesicles derived from diverse sources to regulate M1/M2 macrophage polarization presents a promising strategy for the treatment of periodontitis.…”
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Certain Death: Mike Flanagan’s Gothic Antidote to Traumatic Memory and Other Enlightenment Hang-Overs in <i>Doctor Sleep</i> by Erik Bond

“…In this way, I illustrate and encourage future study of how Gothic texts not only point to marginalized, repressed problems, but more importantly, how they help us relate differently to a traumatic past and innovate strategies for immediate relief from inherited suffering.…”
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Evaluating the Efficacy and Safety of Hepatitis E Vaccination in Reproductive-Age Women: A Systematic Review and Meta-Analysis by Vaidas Jotautis, Antigoni Sarantaki

“…Conclusions: HEV239 is effective in preventing HEV infection among women of childbearing age, although caution is advised when administering the vaccine near conception due to potential miscarriage risks. Future studies should focus on understanding the biological mechanisms and timing-specific safety to guide vaccination recommendations.…”
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Using low-cost sensors to assess common air pollution sources across multiple residences by Catrin J. Rathbone, Dimitrios Bousiotis, Owain G. Rose, Francis D. Pope

“…This method may be applied in future studies for extended periods to investigate the influence of source seasonality on PM concentrations or scaled up to investigate source variability across larger geographical areas.…”
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Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved] by Neil Barnes Abraham, Abhimanyu Pradhan, Suresh Sukumar, Sneha Ravichandran, Winniecia Dkhar, Rajagopal Kadavigere

“…While DWI with ADC mapping shows promise as a reliable diagnostic tool across different hormonal states, further research is needed to fully understand and account for hormonal influences on ADC measurements. Future studies should focus on longitudinal designs, standardization of DWI protocols, and integration of hormonal status information into breast cancer risk assessment models.…”
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A Novel CGM Metric-Gradient and Combining Mean Sensor Glucose Enable to Improve the Prediction of Nocturnal Hypoglycemic Events in Patients with Diabetes by Jingzhen Li, Xiaojing Ma, Igbe Tobore, Yuhang Liu, Abhishek Kandwal, Lei Wang, Jingyi Lu, Wei Lu, Yuqian Bao, Jian Zhou, Zedong Nie

“…Therefore, the proposed method of combining MSG and gradient may enable to improve the prediction of nocturnal hypoglycemic events. Future studies are warranted to confirm the validity of this metric.…”
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Association of ERCC2/XPD polymorphisms and the risk of head and neck carcinoma: a systematic review, meta-analysis, trial sequential analysis, network analysis, and functional effe... by Mohammad Moslem Imani, Ali Ashabi, Farzad Rezaei, Atefe Saffar Shahroudi, Sadegh Kashkouli, Edris Sadeghi, Masoud Sadeghi

“…Conclusions The study reveals a significant association between the rs1799793 polymorphism and HNC, but not rs13181 and rs238406 polymorphisms. Future studies should also aim to minimize the impact of confounding factors and heterogeneity to ensure more accurate results.…”
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Rapid literature mapping on the recent use of machine learning for wildlife imagery by Nakagawa, Shinichi, Lagisz, Malgorzata, Francis, Roxane, Tam, Jessica, Li, Xun, Elphinstone, Andrew, Jordan, Neil R., O'Brien, Justine K., Pitcher, Benjamin J., Van Sluys, Monique, Sowmya, Arcot, Kingsford, Richard T.

“…Our survey, augmented with bibliometric analyses, provides valuable signposts for future studies to resolve and address shortcomings, gaps, and biases. …”
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Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention by Shuyan Liu, Matthias Haucke, Rika Groß, Kay Schneider, Jaekyung Shin, Fabian Arntz, Patrick Bach, Tobias Banaschewski, Christian Beste, Lorenz Deserno, Ulrich Ebner-Priemer, Tanja Endrass, Marvin Ganz, Ali Ghadami, Marco Giurgiu, Andreas Heinz, Falk Kiefer, Reinhold Kliegl, Bernd Lenz, Marta Anna Marciniak, Andreas Meyer-Lindenberg, Andreas B. Neubauer, Michael Rapp, Michael N. Smolka, Jens Strehle, Rainer Spanagel, Gianna Spitta, Heike Tost, Henrik Walter, Hilmar Zech, Dominic Reichert, Markus Reichert

“…Conclusion Our real-life intervention platform endeavors to serve as a robust tool for discerning the directionality of the effects from time series data in everyday life influences on alcohol use for the future study. Ultimately, it will pave the way for low-threshold prevention, clinical treatment, and therapy to target diverse contexts of everyday life in SUD. …”
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Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis by Melissa Ramirez-Villafaña, Ana M. Saldaña-Cruz, Javier A. Aceves-Aceves, Edsaul E. Perez-Guerrero, Nicté S. Fajardo-Robledo, Edy D. Rubio-Arellano, Cesar A. Nava-Valdivia, Maria O. Carrillo-Escalante, Sylvia E. Totsuka-Sutto, David Cardona-Müller, Betsabe Contreras-Haro, Mario Salazar-Paramo, Ernesto G. Cardona-Muñoz, M. Huerta, Jorge I. Gamez-Nava, Norma A. Rodriguez-Jimenez, Laura Gonzalez-Lopez

“…This study encourages the quantification of NPY levels as a surrogate marker for RA-active. Future studies evaluating the role of NPY levels interacting with other proinflammatory cytokines are required.…”
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Thermal Variability in the Martian Upper Atmosphere within the Crustal Magnetic Field Region Induced by Gravity Wave Dissipation Due to Ion-drag Effect by Xing Wang, Xiaojun Xu, Jun Cui, Siqi Yi, Hao Gu, Zilu Zhou, Hengyan Man, Lei Luo, Peishan He, Pu Yang

“…Additional wave processes, including wave breaking and multiwave dissipation, may contribute to the observed thermal variability and should be considered in future studies.…”
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Synthesis of submicronic α-alumina from local aluminum slags by Benkhelif A., Kolli M., Hamidouche M.

“…The obtained powders may also assume applications as a thermally stable substitute for the commonly used transition alumina powders, which needs further investigations in future studies.…”
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Experimental study on pressure relief blasting in rock-blast tunnel by ZhenLin Chen, Wenjing Cai, Meng Wei, Cassandra J. Rutherford, Xiao Zhu, Zelin Wang, Tao Su

“…The traditionally obtained stress attenuation coefficient is shown to require modification through further in-situ experiments. Future studies will refine this coefficient, contributing to the development of more reliable methods for safeguarding urban lifelines. …”
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L-Theanine Extends the Lifespan of <i>Caenorhabditis elegans</i> by Reducing the End Products of Advanced Glycosylation by Zhihang Huang, Haiming Jing, Yan Pan, Hongxia Cai, Wenjing Zhang, Jingyuan Zhu, Nan Zhang, Dan Wu, Wentao Xu, Hexiang Qiu, Huihui Bao, Guojun Li, Junyu Ning, Bo Xian, Shan Gao

“…These findings provide new insights for developing anti-aging strategies and lay the groundwork for further research on the potential benefits of L-theanine in mammals. Future studies could explore the molecular mechanisms, test L-theanine in mammalian models, and assess the long-term side effects.…”
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Tofacitinib downregulates JAK1 and JAK3 on human intestinal monocytes and macrophages without affecting dendritic cells phenotype or function by Elisa Arribas-Rodríguez, Ángel De Prado, Beatriz de Andrés, Benito Velayos, Jesús Barrio, Alejandro Romero, Francisco Javier García-Alonso, Álvaro Martín-Muñoz, José A. Garrote, Eduardo Arranz, Luis Fernández-Salazar, David Bernardo

“…On the contrary, it displays a differential capacity to modulate intestinal monocyte and macrophage phenotype. Future studies should address whether it also translates into a differential function of these cells.…”
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Mineralization Potential of Electrospun PDO-Hydroxyapatite-Fibrinogen Blended Scaffolds by Isaac A. Rodriguez, Parthasarathy A. Madurantakam, Jennifer M. McCool, Scott A. Sell, Hu Yang, Peter C. Moon, Gary L. Bowlin

“…These mineralized scaffolds were still porous and will be further optimized as an effective bone substitute in future studies.…”
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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…Furthermore, our findings underpin the critical role of extrahepatic metabolism in the development of diet-induced steatosis, offering valuable guidance for future studies focused on JNK-targeting for effective treatment of MAFLD.…”
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Standardized Mortality Ratios (SMRs) and Radon Exposure Analysis for Lung Cancer and All-Cause Mortality in Locorotondo, Southern Italy by Giovanni Maria Ferri, Luigi De Maria, Giuseppe Delvecchio, Antonio Caputi, Stefano Sole, Gianmarco Giannelli, Gianfranco Sifanno, Ilaria Maria Di Somma, Floriana Pentimone, Domenica Cavone, Angela Stufano, Piero Lovreglio, Vitantonio Ricci, Luigi Vimercati

“…<i>Conclusions</i>: The natural balance of the population is decreasing, and mortality is decreasing for all causes. A future study will be needed to assess the associations between observed lung cancer cases and domestic radon exposure to drive radon mitigation and public health strategies.…”
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