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22161
Development of Multimorbidity Indexes Based on Common Mental Health Conditions
Published 2025-02-01“…The new indexes had slightly better predictive performance than simple counts of mental disorders.ConclusionWe developed mental multimorbidity indexes as epidemiological research tools. Future prospective studies could investigate their predictive potential regarding outcomes such as medication use, healthcare utilization, and quality of life.…”
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22162
Development of a one-step multiplex RT-qPCR method for rapid detection of bovine diarrhea viruses
Published 2025-01-01“…Notably, this study represents the first identification of BKoV, BoAstV, and BToV in the Shanghai region.DiscussionThe mRT-qPCR is a robust, rapid, and simple tool for identifying viral pathogens associated with calf diarrhea, facilitating the development of effective prevention and control measures that are vital for the future sustainability of the cattle industry.…”
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22163
Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis
Published 2025-01-01“…Pathways significantly impacted by ETI can be further studied for future therapies to combat persistent inflammation and dysregulated immunity.…”
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22164
Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults
Published 2025-02-01“…We determined the presence of genome–microbiome interactions in the resident microbiota of the ear canal. Future studies should focus on ABCC11 gene polymorphisms to elucidate the pathogenesis of ear diseases and develop therapeutic methods.…”
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22165
Tax Exemptions and R;D Expenditures in Iran Saeed Dorokhshi Moghaddam
Published 2024-12-01“…Financial incentives should be utilized in a manner that minimizes costs and maximizes economic growth and productivity. Future research can explore how to optimize the use of these tools, offering valuable insights to policymakers…”
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22166
Research trends and hotspots in post-stroke speech rehabilitation: A bibliometric analysis
Published 2025-04-01“…Objective: This study aimed to identify hotspots and trends in post-stroke speech rehabilitation research from 2003 to 2023 to guide future studies. Methods: Articles on post-stroke speech rehabilitation from 2003 to 2023 were retrieved from the Web of Science Core Collection. …”
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22167
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22168
Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis
Published 2025-03-01“…In order to make recommendations for frailty tools across measurement domains, future studies should compare the diagnostic accuracy to the clinical standard, geriatric assessment, and examine responsiveness to change.…”
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22169
Viral load suppression rate of third-line antiretroviral therapy and its association with gender among HIV patients after second-line treatment failure in Africa: a systematic revi...
Published 2025-02-01“…Therefore, to maintain and further improve the strong viral load suppression rates of TLARVT in Africa, it is essential to focus on appropriate regimen selection, patient counseling and switching, adherence support, and regular viral load testing. Future studies with larger sample sizes should explore the association between gender and viral load suppression to provide conclusive findings.…”
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22170
Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD
Published 2025-01-01“…These findings provide a rationale for a potential immunological approach to treat MASLD in the future.…”
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22171
Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch...
Published 2025-03-01“…We primarily aimed to discover and replicate the association of 274 cardio-metabolic-related proteins with future rates of hip and any fracture in two separate population-based cohorts, with a total of 12,314 women and men. …”
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22172
Navigating complex choices through legitimation: Narrative strategies in risk-reduction mastectomy decision-making among unaffected women with genetic risk for breast cancer in Swi...
Published 2025-06-01“…Participants had either undergone RRM or were planning the surgery in the future. Findings indicate that the decision to undergo RRM was influenced by femininity and body image, current life engagements, anticipation of surgery risks and outcomes, perception and acceptance of cancer risk, surveillance experiences, attitudes of healthcare providers and family, and financial considerations. …”
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22173
Gut mycobiome and neuropsychiatric disorders: insights and therapeutic potential
Published 2025-01-01“…Studies indicate that specific fungal populations, such as Candida and Saccharomyces, may influence neuroinflammation, gut permeability and immune responses, thereby affecting mental health outcomes.ConclusionUnderstanding the gut mycobiome’s role in neuropsychiatric disorders opens new avenues for therapeutic interventions, including antifungal treatments, probiotics, and dietary modifications. Future research should integrate multi-omics approaches to unravel the complex interkingdom interactions within the gut ecosystem, paving the way for personalized medicine in mental health care.…”
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22174
Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic...
Published 2025-02-01“…This approach can not only fill the gap in traditional risk assessment but also provide new ideas for the early identification and intervention of CVD. In the future, the feasibility and effectiveness of this strategy will be verified through multicenter studies, and it is expected to be promoted to a wider medical system, significantly improving the health management level of high-risk groups for CVD.Trial registration numberhttp://itmctr.ccebtcm.org.cn, identifier ITMCTR2024000616.…”
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22175
Definition of sinonasal and otological exacerbation in patients with primary ciliary dyskinesia: an expert consensus
Published 2024-12-01“…They should be validated in future studies and trials together with other potential outcomes, to assess their usability.…”
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22176
Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy
Published 2025-01-01“…As a key direction for future research, relugolix-associated changes to healthy-related quality of life should be contrasted to those brought about by injectable GnRH agonists.…”
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22177
Prevalence of overweight and obesity among preschool children in Hainan: a cross-sectional study in China's largest free-trade zone
Published 2025-01-01“…Based on the risk factors identified in this study, preventive measures can be targeted in the future to reduce the risk of overweight and obesity in preschool children in Hainan Island.…”
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22178
Epidemiological drivers of transmissibility and severity of SARS-CoV-2 in England
Published 2023-07-01“…Long-term strategies for monitoring and maintaining effective immunity against SARS-CoV-2 are critical to inform the role of NPIs to effectively manage future variants with potentially higher intrinsic transmissibility and severe outcomes.…”
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22179
Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation
Published 2023-08-01“…Wortzel, "Psychiatric Advance Directives: Origins, Benefits, Challenges, and Future Directions," Journal of Psychiatric Practice 25, no. 4 (2019): 303-307, https://doi.org/10.1097/PRA.0000000000000401…”
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22180
Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis
Published 2025-02-01“…Although the magnitude of benefit appears to be independent of ethnicity, future clinical trials should devise a standardized method for stratifying patients by ethnicity to more effectively assess potential differences in treatment benefits. …”
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